ABSTRACT: Four new 1,5-benzothiazepines were synthesized by reaction of o-aminothiophenol with curcumin and curcuminoid β-diketones, in methanol and in acetic acid. The mechanism involves a Michael addition on the CC double bond affording a benzothiazepine with two pendant groups, an aryl group adjacent to the sulfur atom and a 1-phenylethanone…
Artículo de Investigación
Reactividad de la curcumina y de las β-dicetonas curcuminoides con el o-aminotiofenol: síntesis de 1,5-benzotiazepinas