Page 63 - 79_03
P. 63
J.
de
Juan--Sanz
&
col.
16.
Kamei
D.;
Yamakawa
K.;
Takegoshi
Y.;
Mikami--Nakanishi
M.;
Nakatani
Y.;
Oh--Ishi
S.;
Yasui
H.;
Azuma
Y.;
Hirasawa
N.;
Ohuchi
K.;
Kawaguchi
H.;
Ishikawa
Y.;
Ishii
T.;
Uematsu
S.;
Akira
S.;
Murakami
M.;
Kudo
I.
Reduced
pain
hypersensitivity
and
inflammation
in
mice
lacking
microsomal
prostaglandin
e
synthase--1.
J.
Biol.
Chem.
279,
33684--33695
(2004).
17.
Mabuchi
T.;
Kojima
H.;
Abe
T.;
Takagi
K.;
Sakurai
M.;
Ohmiya
Y.;
Uematsu
S.;
Akira
S.;
Watanabe
K.;
Ito
S.
Membrane--associated
prostaglandin
E
synthase--1
is
required
for
neuropathic
pain.
Neuroreport
15,
1395--1398
(2004).
18.
Harvey
R.J.;
Depner
U.B.;
Wässle
H.;
Ahmadi
S.;
Heindl
C.;
Reinold
H.;
Smart
T.G.;
Harvey
K.;
Schütz
B.;
Abo--Salem
O.M.;
Zimmer
A.;
Poisbeau
P.;
Welzl
H.;
Wolfer
D.P.;
Betz
H.;
Zeilhofer
H.U.;
Müller
U.
GlyR
a3:
an
essential
target
for
spinal
PGE2--mediated
inflammatory
pain
sensitization.
Science.
304,
884–7
(2004).
19.
Reinold
H.;
Ahmadi
S.;
Depner
U.B.;
Layh
B.;
Heindl
C.;
Hamza
M.;
Pahl
A.;
Brune
K.;
Narumiya
S.;
Müller
U.;
Zeilhofer
H.U.
Spinal
inflammatory
hyperalgesia
is
mediated
by
prostaglandin
E
receptors
of
the
EP2
subtype.
J.
Clin.
Invest.
115,
673–9
(2005).
20.
Malmberg
A.
B.;
Brandon
E.
P.;
Idzerda
R.
L.;
Liu
H.;
McKnight
G.
S.;
Basbaum
A.
I.
Diminished
inflammation
and
nociceptive
pain
with
preservation
of
neuropathic
pain
in
mice
with
a
targeted
mutation
of
the
type
I
regulatory
subunit
of
cAMP--dependent
protein
kinase.
J.
Neurosci.
17,
746--7470
(1997).
21.
Gomeza
J.;
Ohno
K.;
Hülsmann
S.;
Armsen
W.;
Eulenburg
V.;
Richter
D.W.;
Laube
B.;
Betz
H.
Deletion
of
the
mouse
glycine
transporter
2
results
in
a
hyperekplexia
phenotype
and
postnatal
lethality.
Neuron.
40,
797--806
(2003).
22.
Donaldson
L.F.;
Humphrey
P.S.;
Oldfield
S.;
Giblett
S.;
Grubb
B.D.
Expression
and
regulation
of
prostaglandin
E
receptor
subtype
mRNAs
in
rat
sensory
ganglia
and
spinal
cord
in
response
to
peripheral
inflammation.
Prostaglandins.
Other.
Lipid.
Mediat.
63,
109--22
(2001).
23.
Mebane
H.;
Turnbach
M.E.;
Randich
A.
Spinal
EP
receptors
mediating
prostaglandin
E2--
induced
mechanical
hyperalgesia,
thermal
hyperalgesia,
and
touch--evoked
allodynia
in
rats.
J.
Pain.
4,
392--9
(2003).
24.
Breyer
R.M.;
Bagdassarian
C.K.;
Myers
S.A.;
Breyer
M.D.
Prostanoid
receptors:
subtypes
and
signaling.
Annu.
Rev.
Pharmacol.
Toxicol.
41,
661--90
(2001).
25.
Narumiya
S.;
Sugimoto
Y.;
Ushikubi
F.
Prostanoid
receptors:
structures,
properties,
and
functions.
Physiol.
Rev.
79,
1193--226
(1999).
26.
Singh
P.;
Hoggatt
J.;
Hu
P.;
Speth
JM.;
Fukuda
S.;
Breyer
RM.;
Pelus
LM.
Blockade
of
prostaglandin
E2
signaling
through
EP1
and
EP3
receptors
attenuates
Flt3L--dependent
dendritic
cell
development
from
hematopoietic
progenitor
cells.
Blood.
119,
1671--82
(2012).
27.
Iwanaga
K.;
Okada
M.;
Murata
T.;
Hori
M.;
Ozaki
H.
Prostaglandin
E2
promotes
wound--
induced
migration
of
intestinal
subepithelial
myofibroblasts
via
EP2,
EP3,
and
EP4
prostanoid
receptor
activation.
J.
Pharmacol.
Exp.
Ther.
340,
604--11(2012).
28.
Furuyashiki
T.;
Narumiya
S.
Stress
responses:
the
contribution
of
prostaglandin
E(2)
and
its
receptors.
Nat.
Rev.
Endocrinol.
7,
163--75
(2011).
29.
Clasadonte
J.;
Poulain
P.;
Hanchate
NK.;
Corfas
G.;
Ojeda
S.R.;
Prevot
V.
Prostaglandin
E2
release
from
astrocytes
triggers
gonadotropin--releasing
hormone
(GnRH)
neuron
firing
via
EP2
receptor
activation.
Proc.
Natl.
Acad.
Sci.
USA.
108,
16104--9
(2011).
30.
Ushikubi
F.;
Segi
E.;
Sugimoto
Y.;
Murata
T.;
Matsuoka
T.;
Kobayashi
T.;
Hizaki
H.;
Tuboi
K.;
Katsuyama
M.;
Ichikawa
A.;
Tanaka
T.;
Yoshida
N.;
Narumiya
S.
Impaired
febrile
response
in
mice
lacking
the
prostaglandin
E
receptor
subtype
EP3.
Nature.
395,
281--4
(1998).
31.
Matsuoka
Y.;
Furuyashiki
T.;
Yamada
K.;
Nagai
T.;
Bito
H.;
Tanaka
Y.;
Kitaoka
S.;
Ushikubi
F.;
Nabeshima
T.;
Narumiya
S.
Prostaglandin
E
receptor
EP1
controls
impulsive
behavior
under
stress.
Proc.
Natl.
Acad.
Sci.
USA.
102,
16066--71
(2005).
448