Page 34 - 78_03
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NOTICIAS
CIENTÍFICAS…
23.
Kruh,
N.
A.;
Rawat,
R.;
Ruzsicska,
B.
P.;
Tonge,
P.
J.;
(2007)
“Probing
mechanisms
of
resistance
to
the
tuberculosis
drug
isoniazid:
Conformational
changes
caused
by
inhibition
of
InhA,
the
enoyl
reductase
from
Mycobacterium
tuberculosis”,
Protein
Science,
16,
1617--1627.
24.
Vilcheze,
C.,
Weisbrod,
T.
R.;
Chen,
B.;
Kremer,
L.;
Hazbon,
M.
H.;
et
al.;
(2005)
“Altered
NADH/NAD+
ratio
mediates
coresistance
to
isoniazid
and
ethionamide
in
mycobacteria”,
Antimicrob.
Agents
Chemother.,
49,
708--720.
25.
Hartkoorn,
R.
C.;
Sala,
C.;
Neres,
J.;
Pojer,
F.;
Magnet,
S.;
Mukherjee,
R.;
Uplekar,
S.;
Boy--Röttger,
S.;
Altmann,
K.--H.;
Cole,
S.
T.;
(2012)
“Towards
a
new
tuberculosis
drug:
pyridomycin--nature’s
isoniazid”,
EMBO
Mol.
Med.,
4,
1--11.
26.
Glaziou,
P.;
Floyd,
K.;
Raviglione,
M.;
(2009)
“Global
burden
and
epidemiology
of
tuberculosis”,
Clin.
Chest
Med.,
30,
621--636.
27.
Maeda,
K.;
Kosaka,
H.;
Okami,
Y.;
Umezawa,
H.;
(1953)
“A
new
antibiotic,
pyridomycin”,
J.
Antibiot.,
7,
140.
28.
Shomura,
T.;
Amano,
S.;
Yoshida,
J.;
Kojima,
M.;
(1986)
“Dactylosporangiurn
fulvum
sp.
nov.”
Int.
J.
Syst.
Bacterial.,
166--169.
29.
Huang,
T.;
Wang,
Y.;
Yin,
J.;
Du,
Y.;
Tao,
M.:
et
al.;
(2011)
“Identification
and
Characterization
of
the
Pyridomycin
Biosynthetic
Gene
Cluster
of
Streptomyces
pyridomyceticus
NRRL
B--2517”,
J.
Biol.
Chem.,
286,
20648--20657.
30.
Cole,
S.
T.;
Brosch,
R.;
Parkhill,
J.;
Garnier,
T.;
Churcher,
C.;
Harris,
D.;
Gordon,
S.
V.;
Eiglmeier,
K.;
Gas,
S.;
Barry,
C.
E.;
et
al;
(1998)
“Deciphering
the
biology
of
Mycobacterium
tuberculosis
from
the
complete
genome
sequence”,
Nature,
393,
537--544.
31.
Lamichhane,
G.;
(2011)
“Novel
targets
in
M.
tuberculosis:
search
for
new
drugs”,
Trends
Mol.
Med.,
17,
25--33.
297