Page 61 - 88_01
P. 61
ANALES Chen H, Shen Y, Teichman E, Li D, Wang GG, Che X, Kaniskan HU,
RANF Jin J. Harnessing the E3 Ligase KEAP1 for Targeted Protein De-
gradation. J Am Chem Soc. 2021;143(37):15073-15083.
www.analesranf.com 34. Du X, Volkov OA, Czerwinski RM, Tan H, Huerta C, Morton ER, Rizzi
JR, Wehn PM, Xu R, Nijhawan D, Wallace EM. Structural basis and
CRBN E3 ubiquitin ligase in complex with thalidomide. Nature, kinetic pathway of RBM39 recruitment to DCAF15 by a sul-
2014;512(7512):49-53. fonamide molecular glue E7820. Structure.
20. Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Fischer 2019;27(11):1625-1633.e3.
ES. Plasticity in binding confers selectivity in ligand-induced 35. Li L, Mi D, Pei H, Duan Q, Wang X, Zhou W, Jin J, Li D, Liu M, Chen
protein degradation. Nat Chem Biol. 2018;14(7):706-714. Y. In Vivo Target Protein Degradation Induced by PROTACs Based
21. Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle on E3 Ligase DCAF15. Signal Transduct Target Ther.
M, Ciulli A. Structural basis of PROTAC cooperative recognition for 2020;5(1):129.
selective protein degradation. Nat Chem Biol. 2017;13(5):514- 36. Ding Y, Fei Y, Lu B. Emerging new concepts of degrader technologies.
521. Trends Pharmacol Sci. 2020; 41(7):464-74.
22. Crook NE, Clem RJ, Miller LK. An apoptosis-inhibiting baculovirus 37 . Alabi SA, Crews CM. Major advances in the targeted protein
gene with a zinc finger-like motif. J Virol. 1993;67(4):2168-2174. degradation: PROTACs, LYTACs, and MADTACs. J Biol Chem.
23 . Ma Z, Ji Y, Yu Y, Liang D. Specific non-genetic IAP-based 2021;296:100647.
protein erasers (SNIPERs) as a potential therapeutic strategy. Eur 38. Banik S, Pedram K, Wisnovsky S, Riley N, Bertozzi C. Lysosome
J Med Chem. 2021;216:113247. Targeting Chimeras (LYTACs) for the Degradation of Secreted and
24. Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Membrane Proteins. Nature. 2020;584:291-7.
Nishikawa K, Tsuruo T, Natio M. Small molecules destabilize cIAP1 39. Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato
by activating auto- ubiquitylation. J Biol Chem. A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: cargo-specific de-
2008;283(14):8961-8. graders using selective autophagy. Mol Cell. 2019;76:797-810.
25. Ma Z, Ji Y, Yu Y, Liang D. Specific non-genetic IAP-based 40. Li Z, Zhu C, Ding Y, Fei Y, Lu, B. ATTEC: a potential new approach to
protein erasers (SNIPERs) as a potential therapeutic strategy. Eur target proteinopathies. Autophagy 2020;16(1):185-7.
J Med Chem. 2021;216:113247.
26. Huun J, Gansmo LB.; Mannsåker B, Iversen GT, Sommerfelt-Pettersen Si desea citar nuestro artículo:
J, Øvrebø JI, Knappskog S. The Functional Roles of the MDM2 Splice PROTAC: Redirigiendo los sistemas de degradación
Variants P2-MDM2-10 and MDM2-? 5 in Breast Cancer Cells.
Transl Oncol. 2017;10(5):806-817. de proteínas a nuevos sustratos
27. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong Ángel Cores Esperón y Mercedes Villacampa Sanz
N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu E.A. In vivo acti-
vation of the p53 pathway by small-molecule antagonists of MDM2. An Real Acad Farm [Internet].
Science. 2004;303(5659):844-8. An. Real Acad. Farm.Vol. 88. nº 1 (2022) · pp 45-59
28. Schneekloth AR, Pucheault M, Tae HS, Crews CM. Targeted Intrace- DOI: http://dx.doi.org/10.53519/analesranf.2022.88.01.03
llular Protein Degradation Induced by a Small Molecule: En Route
to Chemical Proteomics. Bioorg Med Chem Lett. 2008;18(22):5904-
8.
29. Hines J, Lartigue S, Dong H, Qian Y, Crews CM. MDM2-recruiting
PROTAC offers superior, synergistic antiproliferative activity via si-
multaneous degradation of BRD4 and stabilization of p53. Cancer
Res. 2019;79(1):251-262.
30. Canning P, Sorrell FJ, Bullock AN. Structural basis of Keap1 inter-
actions with Nrf2. Free Radic Biol Med. 2015:88;101-7.
31. Lu M, Liu T, Jiao Q, Ji J, Ta M, Liu Y, Jiang Z. Discovery of a Keap1-
dependent peptide PROTAC to knockdown Tau by ubiquiti-
nation-proteasome degradation pathway. Eur J Med Chem.
2018;146:251-9.
32. Tong B, Luo M, Xie Y, Spradlin JN, Tallarico JA, McKenna JM, Schirle
M, Nomura DK. Bardoxolone conjugation enables targeted protein
degradation of BRD4. Sci Rep. 2020;10(1):15543.
33. Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L,
PROTAC: Redirigiendo los sistemas de degradación 59
de proteínas a nuevos sustratos
Ángel Cores Esperón y Mercedes Villacampa Sanz
An. Real Acad. Farm.Vol. 88. nº 1 (2022) · pp. 45-59
