Page 16 - 83_04

Antimicrobial resistance. Some aspects of a big problem analogues and understanding their role in antibacterial
activities. Chem Commun 2017; 53: 2016-9.
gene aphA6 in Acinetobacter spp. Antimicrob Agents
Chemother 1990; 34: 1244-8. 22. Ginsburg AS, Klugman KP. Vaccination to reduce
antimicrobial resistance. Lancet 217; 5: e1176-7.
11. Yigit H, Queenan AM, Anderson GJ, et al. Novel
carbapenem-hydrolyzing beta-lactamase, KPC-1, from 23. a) Bhargava P, Collins J. Boosting Bacterial
a carbapenem-resistant strain of Klebsiella Metabolism to Combat Antibiotic Resistance. Cell
pneumoniae. Antimicrob Agents Chemother 2001; 45: Metabolism 2015; 21: 154-5. b) Peng B, Su Y, Li H,
1151-61. Han Y, et al. Exogenous Alanine and/or Glucose plus
Kanamycin Kills Antibiotic-Resistant Bacteria. Cell
12. Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, et Metabolism 2015; 21, 249-61.
al. Cloning and characterization of blaVIM, a new
integron-borne metallo-beta-lactamase gene from a
Pseudomonas aeruginosa clinical isolate. Antimicrob
Agents Chemoter 1999; 43: 1584-90.

13. Yong D, Toleman MA, Giske CG, Cho HS, et al.
Characterization of a New Metallo-ß-Lactamase
Gene, blaNDM-1, and a Novel Erythromycin Esterase
Gene Carried on a Unique Genetic Structure in
Klebsiella pneumoniae Sequence Type 14 from India.
Antimicrob Agents Chemother 2009; 53: 5046-54.

14. McGann P, Snesrud E, Maybank R, Corey B, et al.
Escerichia coli Harboring mcr-1 and blaCTX-M on a
Novel Incl Plasmid: First report of mcr-1 in the United
States. Antimicrob Agents Chemother 2016; 60: 4420-
1.

15. Li J, Nation RL, Turnidge JD, Milne RW, Coulthard
K, Rayner VR, Paterson DL. Colistin: the re-emerging
antibiotic for multidrug-resistant Gram-negative
bacterial infections. Lancet Infect Dis 2006; 6: 589-
601.

16. Llewelyn MJ, Fitzpatrick JM, Darwin E, Tonkin-Crine
S, et al. The antibiotic course has had its day. BMJ
2017; 358: j3418.

17. Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL.
Drugs for bad bugs: confronting the challenges of
antibacterial discovery. Nature Rev Drug Discov
2007; 6: 29-40.

18. Jang HJ, Nam SJ, Locke JB, Kauffman CA, et al.
Anthracimycin, a potent anthrax antibiotic from a
marine-derived actinomycete. Angew Chem Int Ed
2013; 52: 7822-4.

19. a) Ling LL, Schneider T, Peoples AJ, Spoering AL, et
al. A new antibiotic kills pathogens without detectable
resistance. Nature 2015; 517: 455-9. b) Avendaño C.
Teixobactin, a new antibiotic that would hardly
produce resistance. An Real Acad Farm 2015; 81: 4-
10.

20. a) Schumacher CE, Harris PWR, Ding XB, Krause B,
et al. Synthesis and biological evaluation of novel
teixobactin analogues. Org Biomol Chem 2017; 15:
8755-60. b) Parmar A, Iyer A, Lloyd DG, Vincent CS,
et al. Syntheses of potent teixobactin analogues
against methicillin-resistant Staphylococcus aureus
(MRSA) through the replacement of l-allo-
enduracididine with its isosteres. Chem Commun
(Camb) 2017 ; 53: 7788-91.

21. Parmar A, Prior SH, Iyer A, Vincent ChS, et al.
Defining the molecular structure of teixobactin

@Real Academia Nacional de Farmacia. Spain 391