Page 78 - 82_ex2

Role of white, brown and perisvascular adipose tissues in the vascular complications associates to obesity

disorders. Nature 2006; 444: 860–7. Jamieson H, Hilmer S, et al. Calorie restriction
induces mitochondrial biogenesis and bioenergetic
25. Racanelli V, Rehermann B. The liver as an efficiency. Proc Natl Acad Sci U S A 2006; 103:
immunological organ. Hepatology 2006; 43, (Suppl 1768-73.
1): S54-62.
39. Liu D, Pitta M, Mattson MP. Preventing NAD (+)
26. Mathieu P, Lemieux I, Després JP. Obesity, depletion protects neurons against excitotoxicity:
inflammation, and cardiovascular risk. Clin Pharmacol bioenergetic effects of mild mitochondrial uncoupling
Ther 2010; 87: 407-16. and caloric restriction. Ann N Y Acad Sci 2008; 1147:
275-82.
27. Lowell BB, S-Susulic V, Hamann A, Lawitts JA,
Himms-Hagen J, Boyer BB, et al. Development of 40. Townsend KL, Tseng YH. Brown adipose tissue.
obesity in transgenic mice after genetic ablation of Recent insights into development, metabolic function
brown adipose tissue. Nature 1993; 366: 740–2. and therapeutic potential. Adipocyte 2012; 1: 13-24.

28. Nisoli E, Tonello C, Carruba MO. Nerve growth 41. Ishibashi J, Seale P. Medicine. Beige can be
factor, beta3-adrenoceptor and uncoupling protein 1 slimming. Science 2010; 328:Ñ 1113-4.
expression in rat brown fat during postnatal
development. Neurosci Lett 1998; 246: 5-8. 42. Langin D. Recruitment of brown fat and conversion of
white into brown adipocytes: strategies to fight the
29. Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin metabolic complications of obesity? Biochim Biophys
B, Haman F, et al. Brown adipose tissue oxidative Acta 2010; 1801: 372-6.
metabolism contributes to energy expenditure during
acute cold exposure in humans. J Clin Invest 2012; 43. Mattson MP. Perspective: Does brown fat protect
122: 545-52. against diseases of aging? Ageing Res Rev 2010; 9:
69-76.
30. Nikami H, Shimizu Y, Endoh D, Yano H, Saito M.
Cold exposure increases glucose utilization and 44. Nedergaard J, Bengtsson T, Cannon B. New powers
glucose transporter expression in brown adipose of brown fat: fighting the metabolic syndrome. Cell
tissue. Biochem Biophys Res Commun 1992; 185: Metab 2011; 13: 238-40.
1078-82.
45. Poher AL, Altirriba J, Veyrat-Durebex C, Rohner-
31. Palomer X, Pérez A, Blanco-Vaca F. Adiponectin: a Jeanrenaud F. Brown adipose tissue activity as a target
new link between obesity, insulin resistance and for the treatment of obesity/insulin resistance Front
cardiovascular disease. Med Clin (Barc) 2005; 124: Physiol 2015; 30: 6:4.
88-95.
46. Elsen M, Raschke S, Eckel J. Browning of white fat:
32. Dallner OS, Chernogubova E, Brolinson KA, does irisin play a role in humans? J Endocrinol 2014;
Bengtsson T. Beta3-adrenergic receptors stimulate 222: R25-38.
glucose uptake in brown adipocytes by two
mechanisms independently of glucose transporter 4
translocation. Endocrinology 2006; 147: 5730-9.

33. Hansen JB, Kristiansen K. Regulatory circuits
controlling white versus brown adipocyte
differentiation. Biochem J 2006; 398: 153-68

34. Eringa EC, Bakker W, van Hinsbergh VW. Paracrine
regulation of vascular tone, inflammation and insulin
sensitivity by perivascular adipose tissue. Vascul
Pharmacol 2012; 56: 204-9.

35. Meijer RI, Serne EH, Smulders YM, van Hinsbergh
VW, Yudkin JS, Eringa EC. Perivascular adipose
tissue and its role in type 2 diabetes and
cardiovascular disease. Curr Diab Rep 2011; 11: 211-
7.

36. Marchesi C, Ebrahimian T, Angulo O, Paradis P,
Schiffrin ELEndothelial nitric oxide synthase
uncoupling and perivascular adipose oxidative stress
and inflammation contribute to vascular dysfunction
in a rodent model of metabolic syndrome.
Hypertension 2009; 54: 1384–92.

37. Sacks HS, Fain JN. Human epicardial fat: what is new
and what is missing? Clin Exp Pharmacol Physiol
2011; 38: 879–87.

38. Redma López-Lluch G, Hunt N, Jones B, Zhu M,

@Real Academia Nacional de Farmacia. Spain 75