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Problems associated with the emission of pharmaceutical products to the environment

Tabla 2. Concentraciones máximas determinadas de productos farmacéuticos (en µg. l-1) en el influente (EDARi) y el efluente (EDARe)
de plantas depuradoras de agua residual, en aguas superficiales (AS), en aguas subterráneas (AP), en aguas de bebida (AB) y en aguas
marinas (AM). (El número de muestras consideradas figura entre paréntesis. El número de países de los que se conocen datos corresponde

a las tres primeras columnas) (85).

Fármaco nº EDARi EDARe AS AP AB AM

Analgésicos países
Ac.acetilsalicílico
Codeína 4 (8)5.0 (129)1.51 (129)0.34 ---- (62)0.001 ---
Diclofenaco
5 (34)3.37 (62)8.1 (110)0.094 (1)0.0 --- ---
Dimetilaminofenazona
15 (249)28 (822)10.96 (1020)1.80 (154)0.93 (86)0.02 (44)0.101
Fenoprofeno
3 (14)0.96 (92)1.0 (168)0.34 (33)0.4 (73)0.006 ---
Hidrocodona
4 ---- (147)5.4 (83)0.02 (7)0.0 ---- ----
Ibuprofeno
Indometacina 3 (7)0.07 (46)0.40 (53)4.15 (1)0.0 ---- ----

Ketoprofeno 15 (217)1.68 (531)95 (1044)6.4 (112)0.0 (99)0.2 (60)0.025
Naproxeno
7 (54)0.211 (300)0.6 (587)0.22 (88)0.0 (55)0.0 ----
Paracetamol
Fenazona 9 (111)10.8 (435)2.10 (599)0.144 (96)0.0 (87)0.0 (46)0.0

Propifenazona 12 (154)611 (490)33.9 (712)4.5 (79)0.14 (23)0.0 (8)0.0

9 (99)246 (162)11.3 (257)3.6 (44)0.0 (17)0.211 (8)0.214

5 (50)0.171 (303)0.9 (518)2.5 (159)3.95 (24)0.4 (44)0.188

5 (34)0.85 (108)0.99 (345)0.88 (75)1.33 (8)0.12 ----

Antibióticos 6 (19)0.0 (95)0.147 (122)0.245 (16)0.1 ---- (20)0.0
amoxicilina 5 (19)0.45 (95)0.4 (52)0.14 (10)0.0 ---- ----
azitromicina 5 (27)0.19 (90)0.56 (387)1.3 (98)0.0 ----
Cloranfenicol 5 (5)171 (80)90.9 (420)0.69 (156)0.0 ---- (20)0.0
7 (7)4.23 (193)5.6 (215)0.36 (10)0.0 (6)0.0 ----
clortetraciclina 5 (123)1.47 (333)4.5 (293)0.95 (152)0.0 ---- ----
Ciprofloxacino 6 (34)10 (37)0.0 ---- ----
Claritromicina 11 (114)1.51 (101)10.9 (328)0.073 (152)0.0 (8)0.005 ----
7 (71)0.96 (325)6.0 (599)1.7 (12)0.0
Doxiciclina 10 (10)0.67 (86)0.33 ---- (12)0.0 (20)0.005
Eritromicina 6 (30)47.0 (161)1.081 (186)0.251 ---- (6)0.0 (20)0.028
Norfloxacina 7 (155)1.5 (91)6.53 (110)0.306 (48)0.0 (2)0.0 (20)0.016
Ofloxacina 7 (32)97.23 (353)1.7 (423)0.34 (159)0.01 (9)0.0
Oxitetraciclina 13 (117)9.0 (121)0.363 (617)0.56 (142)0.24 (24)0.08 ----
Roxitromicina 5 (5)1158.68 (268)4.7 (654)0.408 (166)0.47 (3)0.0 (20)0.031
Sulfametacina 5 (32)48 (29)4.27 (11)0.02 ----
sulfametoxazol 12 (119)7.9 (107)3.6 (851)4.9 (48)0.0 (14)0.0 (20)0.0
Sulfatiazol 5 (124)1.5 (379)2.4 (178)0.52 (164)0.04 (6)0.04 (44)0.081
Tetraciclina (272)0.72 (422)0.11 (59)0.0
Trimetroprim 8 (27)1.236 (877)0.8 ---- ----
(53)0.56 (450)0.28 ---- ----
Trilosina (44)0.125
(78)0.034 ----
Anticoagulantes
Fluoxetina ----

Antiepilépticos 14 (234)9.42 (652)22 (1103)2.5 (226)1.1 (37)0.043 (44)0.997
carbamazepina
---- (44)0.0
A nti ul c e ro s o s 5 (16)1.7 (28)0.61 (128)0.142 ----
Ranitidina ---- (8)0.245
---- (8)0.118
Betabloqueantes 10 (68)122 (223)1.68 (325)0.465 (105)0.0 ---- (8)0.224
Atenolol 10 (81)7.2 (374)9.12 (427)2.2 (128)0.065 ----
8 (83)10 (336)1.111 (400)0.59 (143)0.096 ----
Metoprolol 6 (51)3.526 (171)6.5 (252)0.95 (102)0.56
Propanolol

Sotalol

@Real Academia Nacional de Farmacia. Spain 91