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almostsignificantversusthemalesdrinkingfructosealoneonlyindescendantsfromcontrolmothers(p=0059)Interestingly,thetrendfoundinthenon-HDLcholesterolconcentrationis theopposite than theone found forHDLcholesterolbeingsignificantlymuchhigherintheFChgroupthanintheothertwogroups(CandF)regardlessofthematernaldietTheseresultstakentogetherwiththoseshowninFigure14indicatethatthedistributionofHDLandnon-HDLcholesterollevelsdeeply variesin theFChgroup thisgroupofanimalspresentselevatedplasmanon-HDLcholesterolandlowerHDLcholesterolconcentrationsincomparisontotheothertwogroupswithalsoahighertotalcholesterolconcentrationThiswouldindicatethatahighercholesterolintakebytheseratsproducesanexcessofcholesterol thatisdistributedinlipoproteins suchas VLDLchylomicronsandLDL2bPlasmaHDL cholesterol andnon-HDL cholesterolconcentrationAsTable7indicatestherearestatisticallysignificantdifferencesregardingthediet(D)ofthemaleoffspringforbothHDLcholesterolandnon-HDLcholesterolconcentrationsAfterperformingaposterioriBonferronicorrectionthedataofHDLcholesterolandnon-HDLcholesterolconcentrationscanbeseeninFigure15TheHDLcholesterolconcentrationshowssignificantdecreasein thegroup supplemented with fructoseandcholesterol(FCh)versusthegroupthatdrankwater(C)regardlessofthematernalintakeSincefructosealonealreadyproducedatendencytoadecreaseinHDL-cholesterolinmalesfromfructose-fedmothers(butnotintheoffspringfromcontrolmothers)(Figure11)thediminutionobservedin themalesreceiving fructosepluscholesterolbecame270ANALESRANFwwwanalesranfcomLaingestamaternade fructosamodulaelmetabolismodelcolesterolenrespuestaaunadietaoccidentalenladescendenciaPalomaLópezLaizElenaFausteetalAnRealAcadFarmVol88Nº3(2022)·pp257-275Figure14Plasmatotalcholesterolandtriglyceridesconcentrationinthemaleprogeny,after21daysofreceivingdifferenttreatments(bluebarwater–Corangebarfructose–F,purplebarfructose+cholesterol-richdiet–FCh)Thebarsthatpresentalightercolourcorrespondtothedescendantsofmothersthatweregivenwaterduringgestation(maternalcontrolgroup)andthebarswithadarkercolour,tothedescendantsofmothersthatdrankafructosesolutionduringgestation(maternalfructosegroup)Thedatapresentedaremeans±standarderror(SE)Thesymbol*denotesstatisticallysignificantdifferencesbetweendietsTable7HDLcholesterolFPvalueη2MOTHER011007420003DIET1151900000390MOTHER*DIET084504380045non-HDLcholesterolFPvalueη2MOTHER000809280000DIET5972500000773MOTHER*DIET057205700032Table7Two-wayANOVAofplasmaHDLandnon-HDLcholesterolFSnedecorsF,whichisastatisticparameterbasedonanalysisofthevariancePvalueprobabilityofobservingavaluewhichisatleastasextremeasthevalueobtainedfromthetest2proportionofthevariancethatisattributedtothemother,thedietortheinteractionbetweenbothThegreencolourinthecellindicatesthatthedifferenceisstatisticallysignificant