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againstcardiovasculardiseasesInterestingly,indescendantsfromfructosefedmothersatrendtodecreaseinHDL-cholesterolwasfoundinmalesreceivingbothfructoseandtagatoseincomparisontomalesdrinkingwater.Regarding thenon-HDLcholesterolconcentration the treatmentreceivedbythemalesinthematernalcontrolgroupdoesproducestatisticallysignificantdifferencesespeciallybetweentheonesthatdrankwaterandthosesupplementedwithtagatoseshowingthislastgrouphighernon-HDLcholesterollevelsCuriously,this tagatose-inducedeffect wasagainnotobservedindescendantsoffructose-mothersand thisobservationwascoincident to thatonefoundfortotalcholesterollevels(Figure10)AfterperformingtheBonferronitestasitcanbeseeninFigure11nostatisticallysignificantdifferencesarefoundintheHDLcholesterolNeverthelessthereisatendencyofhigherHDLcholesterollevelsinthegroupofmalesfromcontrolmothersthatdrank the tagatose solution versusthosedrinking waterand fructoseHowever,theeffectwasnotobservedinthedescendantsoffructosesupplementedmothersCuriously, thereisanalmost statistically significantdecreaseinHDLcholesterollevels(p=0086denoted witha&symbolinFigure11)oftagatosesupplementeddescendantsfrom fructose-mothers whencompared with thedescendantsofcontrol-mothersThisdecreasewouldbeanon-desirableeffectsinceHDLisknownas“goodcholesterolsuggestingalowerprotection266ANALESRANFwwwanalesranfcomLaingestamaternade fructosamodulaelmetabolismodelcolesterolenrespuestaaunadietaoccidentalenladescendenciaPalomaLópezLaizElenaFausteetalAnRealAcadFarmVol88Nº3(2022)·pp257-275HDLcholesterolFPvalueη2MOTHER055404610015DIET158602190081MOTHER*DIET208101400104non-HDLcholesterolFPvalueη2MOTHER310000870079DIET297400640142MOTHER*DIET203013460070Table3Two-wayANOVAofHDLandnon-HDLcholesterolplasmalevelsFSnedecorsF,whichisastatisticparameterbasedontheanalysisofvariancePvalueprobabilityofobservingavaluewhichisatleastasextremeasthevalueobtainedfromthetest2proportionofthevariancethatisattributedtothemother,thedietortheinteractionbetweenbothTheyellowcolourinthecellindicatesthatthedifferenceisalmoststatisticallysignificantTable3Figure11PlasmaHDLcholesterolandnon-HDLcholesterolconcentrationin themaleprogeny,after 21daysofreceivingdifferent treatments(bluebar water–Corangebar fructose–F,greenbartagatose–T) Thebars thatpresentalightercolourcorrespond to thedescendantsofmothers that weregiven waterduringgestation(maternalcontrolgroup)andthebarswithadarkercolour,tothedescendantsofmothersthatdrankafructosesolutionduringgestation(maternalfructosegroup)Thedatapresentedaremeans±standarderror(SE)Thesymbol*denotesstatisticallysignificantdifferencesbetweendietsandthe#betweenmaternalintakeThesymbol(&)correspondstodifferencesthatarealmoststatisticallysignificantbetweenmaternalintake