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Curiously, this trendhadbeenalreadyobserved formalesreceivingfructosealone2dCoronaryRiskIndex(CRI)and AtherogenicIndexofPlasma(AIP)Table9indicatesdifferencesregardingthediet(D)forbothindexes(p=0000forboth)andalsoregardingtheinteractionofthedietofthemaleprogenyandthematernalfeedingfortheAtherogenicIndexofPlasmaAsshowninFigure17intheCoronaryRiskIndextherearestatisticallysignificantdifferencesbetweentheFChgroupandtheothertwogroupscontrolandfructoseindependentlyofmaternalintaketotalcholesterolconcentrationtriglycerideslevelsandespeciallythenon-HDLcholesterolconcentrationinplasmaThegeneexpressionofhepaticLDLRexhibitsadecreasing trend for theFChgroup theeffectbeingsignificantlydifferentversusmalesdrinkingonlywaterwhentheycomefromcontrolmothersAstheLDLRgeneisassociatedwiththeuptakeofnonHDLcholesterolfromthebloodintotheliver,thisresultwouldcorrelate with thehigherconcentrationofnon-HDLcholesterol foundinthisgroup(Figure15)Inaddition theSR-B1geneexpressionalsoshowsaslightdecreasing trendbetween thecontrolandFChgroupindescendantsfromcontrolmothersbutnotinoffspringfromfructose-fedmothers272ANALESRANFwwwanalesranfcomLaingestamaternade fructosamodulaelmetabolismodelcolesterolenrespuestaaunadietaoccidentalenladescendenciaPalomaLópezLaizElenaFausteetalAnRealAcadFarmVol88Nº3(2022)·pp257-275Figure16MTTP,LDLRandSR-B1hepaticgeneexpressioninthemaleprogeny,after21daysofreceivingdifferenttreatments(bluebarwater–Corangebarfructose–F,purplebarfructose+cholesterol-richdiet–FCh)Thebarsthatpresentalightercolourcorrespondtothedescendantsofmothersthatweregivenwaterduringgestation(maternalcontrolgroup)andthebarswithadarkercolour,tothedescendantsofmothersthatdrankafructosesolutionduringgestation(maternalfructosegroup)Thedatapresentedaremeans±standarderror(SE)Thesymbol#representsstatisticallysignificantdifferencesbetweenmaternalintakesTable9CRIFPvalueη2MOTHER094403380027DIET6407300000790MOTHER*DIET037406910022AIPFPvalueη2MOTHER682400130167DIET1420200000455MOTHER*DIET322900520160Table9Two-wayANOVAofCoronaryRiskIndexandAtherogenicIndexofPlasmaFSnedecorsF,whichisastatisticparameterbasedontheanalysisofvariancePvalueprobabilityofobservingavaluewhichisatleastasextremeasthevalueobtainedfromthetest2proportionofthevariancethatisattributedtothemother,thedietortheinteractionbetweenbothThegreencolourinthecellindicatesthatthedifferenceisstatisticallysignificant