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ming fructose(p=0075)Moreover,asit wasalsoobserved for totalcholesterolHDLcholesterolandnon-HDLcholesterollevels(Figures10and11)theconsumptionoffructosebythemothershasadampeningactionintheeffectoftagatoseongeneexpressionConsequently,analmost statistically significantdifferencebetween the twogroupsoftagatosesupplementedratswasobserved(denotedbya&symbolinFigure12LDLR)Thisresultdoesnotexplainthefindingsobservedinplasmanon-HDLcholesterolasanincreaseintheexpressionofLDLRwouldmeanthatmoreLDLcholesterolwouldbe takenby theliveranddiminishednon-HDLcholesterollevelswouldbefoundinbloodIncontrastplasmanon-HDLcholesterolconcentrationturnedouttobemoreelevatedinmalesconsumingtagatoseincomparisontotheothertwogroupsisalmoststatisticallysignificantversusthedescendantsdrinkingwaterinthecontrolmaternalgroupwhichwouldmeanthattheconsumptionof fructoseincreases theexpressionofMTTP.Given thatthisgeneisinvolvedintheproductionofnon-HDLcholesterolonewouldexpectahigherconcentrationof thisparameterinmalesconsuming fructose thanin thosedrinkingonly water.However, thiseffectcannotbeseeninFigure11(non-HDL)NeverthelesssinceMTTPproteinalsoparticipatesintheassemblyofTG-richlipoproteinstobereleasedbythehepatocyteitislogicaltofindasimilartrendtoincreaseinplasmaTGofmalesreceivingfructose(Figure10)OntheotherhandhepaticLDLRgeneexpressiontendstoincreaseafterconsumingtagatoseindescendantsofcontrolmothersbecomingalmostsignificantincomparisontomalesconsu268ANALESRANFwwwanalesranfcomLaingestamaternade fructosamodulaelmetabolismodelcolesterolenrespuestaaunadietaoccidentalenladescendenciaPalomaLópezLaizElenaFausteetalAnRealAcadFarmVol88Nº3(2022)·pp257-275CRIFPvalueη2MOTHER246201260066DIET115703260062MOTHER*DIET068805090038AIPFPvalueη2MOTHER368800630098DIET577700070254MOTHER*DIET453700180211Table5Two-wayANOVAofCoronaryRiskIndexandAtherogenicIndexofPlasmaFSnedecorsF,whichisastatisticparameterbasedontheanalysisofvariancePvalueprobabilityofobservingavaluewhichisatleastasextremeasthevalueobtainedfromthetest2proportionofthevariancethatisattributedtothemother,thedietortheinteractionbetweenbothThegreencolourinthecellindicatesthatthedifferenceisstatisticallysignificantwhileyellowrepresentsthatthedifferenceisalmoststatisticallysignificantTable5Figure13CoronaryRiskIndexandAtherogenicIndexofPlasmaobtainedaftercalculationofwithdatafromthesamplesobtainedafter21daysofreceivingdifferenttreatments(bluebarwater–Corangebarfructose–F,greenbartagatose–T)Thebarsthatpresentalightercolourcorrespondtothedescendantsofmothersthatweregivenwaterduringgestation(maternalcontrolgroup)andthebarswithadarkercolour,tothedescendantsofmothersthatdrankafructosesolutionduringgestation(maternal fructosegroup) Thedatapresentedaremeans±standarderror(SE) Thesymbol*representsstatisticallysignificantdifferencesbetweendietsandthe#betweenmaternalintakes