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265ANALESRANFwwwanalesranfcomMaternalfructoseintakemodulatescholesterolmetabolisminresponsetoaWesterndietintheoffspringPalomaLópezLaizElenaFausteetalAnRealAcadFarmVol88nº3(2022)·pp257-27541bHDLcholesterolandnon-HDLcholesterolconcentrationinplasmaTo furtherstudyif there wasaneffectincholesterolmetabolismdue to fructoseor tagatoseintakeHDLcholesterolandnonHDLcholesterollevels weredetermined Asshownin Table3 therearenosignificantdifferencesintheHDLcholesterolthatcouldbeattributedtothedietthemothersorthesumofbothfactorsHowever,regardingnon-HDLcholesterolboth theconsumptionof themothers(M)duringthegestationandthediets(D)thatthemaleoffspringreceived showedalmost statistically significantdifferences(Mp=0087;Dp=0064)Table2effectdisappears with fructoseconsumptionduringgestation AsindicatedinFigure10withahash(#)cholesterollevelsin tagatosesupplementeddescendantsfromcontrolmothersaresignificantlyhigher than thoseof tagatose supplementeddescendants from fructosemothersOntheotherhandthereisatendencytoincreasetheplasma triglycerideslevelsin thosegroupsofdescendantsreceivinganycarbohydrate(fructoseor tagatose) versusdescendants thatconsumedwater.Moreover,thistrendwasobservedregardlessofthedietofthemothersTable2Two-wayANOVAoftotalCholesterolandTriglycerideconcentrationsinplasmaFSnedecorsF,whichisastatisticparameterbasedontheanalysisofvariancePvalueprobabilityofobservingavaluewhichisatleastasextremeasthevalueobtainedfromthetest2proportionofthevariancethatisattributedtothemother,thedietortheinteractionbetweenbothTheyellowcolourinthecellindicatesthatthedifferenceisalmoststatisticallysignificantCholesterolFPvalueη2MOTHER127202670033DIET248500970118MOTHER*DIET203001460099TriglyceridesFPvalueη2MOTHER397400540097DIET251700940120MOTHER*DIET011308930006Figure10Plasma totalcholesteroland triglycerideslevelsin themaleprogeny,after 21daysofreceivingdifferent treatments(bluebar water–Corangebar fructose–F,greenbartagatose–T)Thebarsthatpresentalightercolourcorrespondtothedescendantsofmothersthatweregivenwaterduringgestation(maternalcontrolgroup)andthebarswithadarkercolour,tothedescendantsofmothersthatdrankafructosesolutionduringgestation(maternalfructosegroup)Thedatapresentedaremeans±standarderror(SE)Thesymbol*indicatesstatisticallysignificantdifferencesbetweendietsandthe#betweenmaternalintake