Page 38 - 84_02

Discovery and handling of Genes. Connetions with Biology and Medicine

88. a) Liang P, Xu Y, Zhang X, Ding Ch, et al.
CRISPR/Cas9-mediated editing in human
triplonoclear zygotes. Protein & Cell 2015; 6: 1-10. b)
Ver la noticia en Nature News, 22 de abril 2015:
Cyranoski D, Reaedon S. “Chinese scientists
genetically modify human embryos”.

89. Kang X, He W, Huang Y, Yu Q, et al. Introducing
precise genetic modifications into human 3PN
embryos by CRISPR/Cas-mediated genome editing.
Journal of Assisted Reproduction and Genetics 2016;
33: 581-8.

90. Ma H, Marti-Gutierrez N, Park S-W, Wu J, et al.
Correction of a pathogenic gene mutation in human
embryos. Nature 2017; 548: 413-9.

91. Cordeiro JL, Wood DW. “La muerte de la muerte”.
Editorial Deusto 2017.

92. Hammond A, Galizi R, Kyrou K, Simoni A, et al. A
CRISPR-Cas9 gene drive system targeting female
reproduction in the malaria mosquito vector
Anopheles gambia. Nature Biotechnology 2016; 34:
78-83.

93. Leitschuh CM, Kanavy D, Backus GA, Valdez RX,
Serr M, Pitts EA, Threadgill D, Godwin J. Developing
Gene Drive Technologies to Eradicate Invasive
Rodents From Islands, 2018; Journal of Responsible
Innovation 5 (S1): S13–S39.

94. Oye KA, Esvelt K, Appleton E, Catterucci F, et al.
Regulating gene drives. Science 2014; 345: 626-8.

95. Esvelt KM, Gemmell NJ. Conservation demands safe
gene drive. PLOS Biology 2017;
https://doi.org/10.1371/journal.pbio.2003850.

96. Baltimore D, Berg P, Botchan M, Carroll D, et al. A
prudent path forward for genomic engineering and
germline gene modification. Science 2015; 348: 36-8.

97. Collins FS. “The Language of God”. Free Press, New
York, London, Toronto Sydney, 2006.

@Real Academia Nacional de Farmacia. Spain 153