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Biological Activity of New 1,8-Diaza-2,9,10-                                           M.ª del Carmen Avendaño López

anthracenetrione Derivatives. J Pharm Sci                    one (carbostyril) anions as bidentate nucleophiles in
                                                             their reactions with aryllead triacetates: synthesis of 1-
1992;81:815-6. d) González R, Ramos MT, de la                aryl and 3-aryl-tetrahydroquinoline-2,5,8-triones. J
                                                             Chem Soc (Perkin 1) 1996;229-33. s) Pérez JM,
Cuesta E, Avendaño C. Base-Catalyzed Electrophilic           Avendaño C, Menéndez JC. A Very Efficient
                                                             Synthesis of 1,8-Diazaanthraquinones. Tetrahedron
Substitution in 2(1H)-quinolinone. Heterocycles              Lett 1997;38:4717-20. t) Pérez JM, López-Alvarado
                                                             P, Avendaño C, Menéndez JC. Total Synthesis of
1993;36:315-22. e) Alonso MA, Blanco MM,                     Diazaquinomycin A. Tetrahedron Lett 1998;39:673-6.
                                                             u) Avendaño C, Menéndez JC. Recent progress in the
Avendaño C, Menéndez JC. Synthesis of 2,5,8-(1H)-            Synthesis of Antitumour Azaanthraquinones. Recent
                                                             Res Develop in Org Chem 1998;2:69-86. v) López-
quinolinetrione derivatives through Vilsmeier-Haack          Alvarado P, Avendaño C, Menéndez JC. A General
                                                             Synthesis of Quinoline-2,5,8(1H)-triones via
formylation of 2,5-dimethoxyanilides. Heterocycles           Acylation of 2,5-Dimethoxyaniline with S-tert-Butyl
                                                             Thioacetates by Application of the Knorr Cyclization.
1993;36:2315-25. f) Alonso MA, Úbeda JI, Avendaño            Synthesis 1998;186-94. x) Avendaño C, Pérez JM,
                                                             Blanco MM, de la Fuente JA, Manzanaro S, Vicent
JI, Menéndez JC, Villacampa M. New findings on the           MJ, Martín MJ, Salvador-Tormo N, Menéndez JC.
                                                             Synthesis and structure–activity relationships of 1,5-
Vilsmeier Haack-Approach to Quinoline Derivatives.           diazaanthraquinones as antitumour compounds.
                                                             Bioorg Med Chem Lett 2004;14:3929-32.
Tetrahedron 1993;47:10997-11008. g) Pérez JM,
                                                        11. a) Avendaño C, Alonso MA, Espada M, García-
Vidal L, Grande MT, Menéndez JC, Avendaño C.                 Grávalos D, Menéndez JC, Ocaña B, Pérez JM. "New
                                                             Synthetic Antitumoral Compounds¨, patentes No.
Regioselectivity of the Diels-Alder Reactions of             9212222000.5 (Gran Bretaña. 5/06/92), No. 0 574 195
                                                             (EEUU, 15/12/93), y otras solicitudes en Canadá,
2,5,8(1H)-Quinolinetriones.      Tetrahedron                 Japón, Australia y Suráfrica. b) Avendaño C, García-
                                                             Grávalos D. "Nuevos Derivados Antraquinónicos con
1994;50:7923-32. Ocaña B, Espada M, Avendaño C.              Actividad Antitumoral y sus Aplicaciones". Patente
                                                             Internacional No. WO 95/2314 (31/08/1995). c)
N-Oxides of Azaanthraquinones. Tetrahedron                   Avendaño C, Pérez JM, Blanco M.M, Menéndez JC,
                                                             García-Grávalos D, de la Fuente J.A, Martín J.A.
1994;50:9505-10. h) Marcos A, Pedregal C,                    "Antitumour 1,5-diazaanthraquinones", International
                                                             Publication Number: WO 99/59996 (25/11/99).
Avendaño C. Synthesis of 2- and 4-oxo-1H-1-

azaanthracene-9,10-dione from 2-Amino-1,4-

naphthoquinone. Tetrahedron 1994; 50, 12941-52. i)

Ocaña B, Espada M, Avendaño C. Reactions of Aza-

and Diazaanthraquinone N-oxides. Tetrahedron 1995;

51: 1253-58. j) Villacampa M, de la Cuesta E,

Avendaño C. Regioselective Synthesis of 1,8-

Diazaanthracene-9,10-dione by Tandem Directed

ortho-Metallation/Metal-Halogen  Exchange.

Tetrahedron 1995;51:1259-64. k) Marcos A, Pedregal

C, Avendaño C. Synthesis of 1,5- and 1,8-

Diazaanthraquinones by Reaction of

Aminoquinolinequinones with ß-dielectrophiles.

Tetrahedron 1995;51:1763-74. l) Pérez JM,

Avendaño C, Menéndez JC. 1-Acylamino-1-azadienes

as an alternative to 1-dimethylamino-1- azadienes in

the preparation of 1,8-diazaanthracene-2,9,10-triones.

Tetrahedron 1995;51:6573-86. m) Martín O, de la

Cuesta E, Avendaño C. Electrophilic Substitution in

3-and 4-Methyl-2(1H)quinolinone through Metallated

Species. Tetrahedron 1995;51:7547-54. n) Ferrer P,

Avendaño C, Söllhuber MM. Synthesis of 5,8-

Dimethoxy-2(1H)quinolinones by Intramolecular

Wittig Reaction. Liebigs Ann 1995;1895-9. ñ)

Fernández M, de la Cuesta E, Avendaño C.

Metallation of 2(1H)-Quinolinone: Synthesis of 3-

Substituted Compounds. Synthesis 1995;11:1362-4. o)

Ramos MT, Díaz-Guerra LM, García-Copín S,

García-Grávalos D, García de Quesada T, Avendaño

C. Synthesis and Antitumor Activity of Fluorinated 1-

Aza and 1,8-Diazaanthraquinones. Il Farmaco

1996;51:375-9. p) Blanco MM, Alonso MA,

Avendaño C, Menéndez JC. New Findings in Hetero

Diels-Alder Reactions of Quinolinetriones.

Tetrahedron 1996;52:5933-44. q) Moreno T,

Fernández M, de la Cuesta E, Avendaño C.

Metallation of Methoxy-2(1H)-Quinolinones.

Heterocycles 1996;43:817-28. r) López-Alvarado P,

Avendaño C, Menéndez JC. 1,2-Dihydroquinolin-2-

128 @Real Academia Nacional de Farmacia. Spain
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