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Carmen Avendaño

     6. c) Agnandji ST, Lell B, Fernandes JF, et al. A         candidate malaria vaccine RTS,S/AS02 following
     Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in
     African Infants. New England Journal of Medicine          administration to semi-immune adult men living in a
     2012; 367: 2284-95.
                                                               malaria-endemic region of The Gambia. Hum Vaccin
11. Plassmeyer ML, Reiter K, Shimp RL Jr, et al. Structure
     of the Plasmodium falciparum circumsporozoite             2009; 5: 242-47.
     protein, a leading malaria vaccine candidate. J Biol
     Chem 2009; 284: 26951-63.                                 24. WHO Initiative for vaccine research/global malaria

12. Coppi A, Pinzón-Ortiz C, Hunter Ch. The Plasmodium         programme joint technical expert group (JTEG) on
     circumsporozoite protein is proteolytically processed
     during cell invasion. JEM 2005; 201: 27-33.               malaria vaccines entering pivotal Phase 3 trials &

13. Aldrich C, Magín A, Emiliani C, et al. Roles of the        beyond    (established         April  2009).
     Amino Terminal Region and Repeat Region of the
     Plasmodium berghei Circumsporozoite Protein in            http://www.who.int/immunization/research/committee
     Parasite Infectivity. PLoS One 2012; 7: e32524.
                                                               s/jteg/en (accessed April 22, 2015).
14. Coffman RL, Sher A, Seder RA. Vaccine adjuvants:
     putting innate immunity to work. Immunity 2010;           25. Keiser J, Utzinger J, Premji Z, Yamagata Y, Singer
     33:492-503.
                                                               BH. Acridine Orange for malaria diagnosis: its
15. Myers KR, Truchot AT, Ward J, et al. A critical
     determinant of lipid A endotoxic activity. In:            diagnostic performance, its promotion and
     Nowotny A, Spitzer JJ, Ziegler EJ, editors. Cellular
     and Molecular Aspects of Endotoxin Reactions.             implementation in Tanzania, and the implications for
     Amsterdam: Elsevier Sciences Publishers B V; 1990.
     pp. 145-56.                                               malaria control. Ann Trop Med Parasitol 2002; 96:

16. Ragupathi G, Gardner JR, Livingston PO, Gin DY.            643-54.
     Natural and synthetic saponin adjuvant QS-21 for
     vaccines against cancer. Expert Rev Vaccines 2011;        26. Spielman A, Perrone JB, Teklehaimanot A, et al.
     10:463-70.
                                                               Malaria Diagnosis by Direct Observations of
17. Chea EK, Fernández-Tejada A, Damani P, et al.
     Synthesis and Preclinical Evaluation of QS-21             Centrifuged Samples of Blood. Am J Trop Med Hyg
     Variants Leading to Simplified Vaccine Adjuvants          1988; 39: 337-42.
     and Mechanistic Probes. J Am Chem Soc 2012, 134:
     13448-57.                                                 27. Engelbrecht F, Tögel E, Beck HP. Analysis of

18. Para el registro de este ensayo ver: ClinicalTrials.gov,   Plasmodium falciparum infections in a village
     número NCT00866619.
                                                               community in Northern Nigeria: determination of
19. a) RTS,S Clinical Trials Partnership. First results of
     Phase 3 trial of RTS,S/AS01 malaria vaccine in            msp2 genotypes and parasite-specific IgG responses.
     African children. N Engl J Med 2011; 365: 1863-75.
     b) RTS,S Clinical Trials Partnership. A Phase 3 trial     Acta Tropica 2000; 74: 63-71.
     of RTS,S/AS01 malaria vaccine in African infants. N
     Engl J Med 2012; 367: 2284-95.                            28. Ochola LB, Vounatsou P, Smith T, Mabaso MLH,

20. Foquet L, Hermsen C, van Gemert G-J, et al. Vaccine-       Newton CRJC. The reliability of diagnostic
     induced monoclonal antibodies targeting
     circumsporozoite protein prevent Plasmodium               techniques in the diagnosis and management of
     falciparum infection. J Clin Invest 2014; 124: 140-4.
                                                               malaria in the absence of a gold standard. The Lancet
21. RTS,S Clinical Trials Partnership. Efficacy and safety
     of the RTS,S/AS01 malaria vaccine during 18 months        Infectious Diseases 2006; 6: 582-88.
     after vaccination: a Phase 3 randomized, controlled
     trial in children and young infants at 11 African sites.  29. a) Sibley CH, Ringwald P. A database of antimalarial
     PLoS Med 2014; 11: e1001685.                                   drug resistance. Malar J 2006; 5: 48-56. b) Alonso PL,

22. Greenwood BM y otros muchos autores. Efficacy and          Brown G, Arévalo-Herrera M, et al. A research
     safety of RTS,S/AS01 malaria vaccine with or without
     a booster dose in infants and children in Africa: final   agenda to underpin malaria eradication. PLOS Med
     results of a Phase 3, individually randomised,
     controlled trial. Lancet 2015; S0140-6736(15)60721-       2011; 8: e1000406. c) Petersen I, Eastman R, Lanzar
     8. 23. Bojang K, Milligan P, Pinder M, et al. Five-year
     safety and immunogenicity of GlaxoSmithKline’s            M. Drug-resistant malaria: molecular mechanisms and

    156                                                        implications for public health. FEBS Lett 2011; 585,

                                                               1551-62.

                                                               30. Algunos comentarios acerca de su uso y mecanismos
                                                                    de acción pueden encontrarse en: a) Avendaño C. La

                                                               innovación farmacéutica. Comentarios sobre tres

                                                               noticias. Anal Real Acad Nac Farm 2005; 71: 873-

                                                               904. b) Avendaño C. Los productos naturales en la

                                                               búsqueda de nuevos fármacos. Una visión de

                                                               conjunto. Anal Real Acad Nac Farm 2011; 77: 15-35.

                                                               31. White NJ. The Treatment of Malaria. N Engl J Med

                                                               1996; 335: 800-06.

                                                               32. Ver por ejemplo: Njhomaer S. Is sulphadoxine-

                                                               pyrimethamine (SP) still useful as the first-line

                                                               antimalarial drug in Malawi or it must be quickly

                                                               withdrawn from the antimalarial repertoire?. Malawi
                                                               Med J 2007; 19: 37-38.

                                                               33. Ver por ejemplo: Winstaley P. Modern

                                                               chemotherapeutic options for malaria. Lancet Infect
                                                               Dis 2001; 1: 242-50.

                                                               34. Robert A, BenoitVical F, DechyCabaret O, Meunier B.

                                                               From classical antimalarial drugs to new compounds

                                                               @Real Academia Nacional de Farmacia. Spain
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