Page 47 - 81_02

Senses 2001; 26:845-60. J. I. Espada García et al.
of cyclodextrins II: In vivo drug delivery. J Pharm Sci
17. Coupland JN, Hayes JE. Physical approaches to 1996, 85:1142–69.
masking bitter taste: lessons from food and 34. Rowe RC, Sheskey PJ, Quinn ME. Handbook of
pharmaceuticals. Pharm Res 2014;31:2921-39. pharmaceutical excipients. 6th ed. United kingdom
and United States of America: Pharmaceutical Press
18. Shi P, Zhang J. Contrasting modes of evolution 2009.
between vertebrate sweet/umami receptor genes and 35. Kuno Y, Kojima M, Ando S, Nakagimi H. Evaluation
bitter receptor genes. Mol Biol Evol 2006; 23:292– of rapidly disintegrating tablets by phase transition of
300. sugar alcohols. J Control Release 2005;105:16-22.
36. Chase GD, Gennaro AR, Gibson MR. Pharmaceutical
19. Meyerhof W, Batram C, Kuhn C, Brockhoff A et al. Necessities. In Remington’s Pharmaceutical sciences.
The molecular receptive ranges of human TAS2R 16th ed. Pennsylvania: Mack publishing company;
bitter taste receptors. Chem Senses 2010;35:157–70. 1980.
37. Tordoff MG, Bachmanov AA. Mouse taste preference
20. Ley JP. Masking bitter taste by molecules. Chem. tests: why only two bottles? Chem Senses 2003; 28:
Percept 2008; 1:58–77. 315–24.
38. Anand V, Kataria M, Kukkar V, Saharan V,
21. Mackles L, Chavkin L. Tasteless forms of basic drugs Choudhury PK. The latest trends in the taste
prepared by absorption in situ. United states patent assessment of pharmaceuticals. Drug Discov Today
U.S 5811131. 1998. 2007;12: 257-65.
39. Ming D, Ruiz-Avila L, Margolskee RF.
22. Patil V, Tambe V, Pathare B, Dhole S. Modern taste Characterization and solubilization of bitter-
concealing techniques in pharmaceuticals: a review. responsive receptors that couple to gustducin. Proc
WJPPS 2014, 3: 293-316 Natl Acad Sci. USA 1998; 95: 8933–38.
40. Mifsud JC, Lucas Q. Alpha M.O.S. Apparatus and
23. Patell MH. Taste masking pharmaceutical agents. method for characterizing liquids. United States patent
United States patent US 4916161. 1990. US 6290838. 2003.

24. Mackles L, Chavkin L. Aerosol foam with adsorbate @Real Academia Nacional de Farmacia. Spain
and container containing same United States patent
US 4,889,709. 1989.

25. Eichmann ML. Drug resin complexes stabilized by
chelating agents. United States patent U.S. 5980882.
1999.

26. Appelgren C, Eskilson C. A novel method for the
granulation and coating of Pharmacologically active
substances. Drug Dev Ind Pharm 1990; 16: 2345-51.

27. Xu J, Bovet LL, Zhao K. Taste masking microspheres
for orally disintegrating tablets. Int J Pharm 2008;
359: 63-9.

28. Bruschia ML, Cardosoa MLC, Lucchesib MB,
Gremiao MPD. Gelatin microparticles containing
propolis obtained by spray-drying technique:
preparation and characterisation. Int J Pharm 2003;
264: 45–55.

29. Kajiyama A, Tamura T, Mizumoto T, Kawai H,
Takahashi T. Quick disintegrating tablet in buccal
cavity and manufacturing method thereof. United
States patents US 6656492. 2003.

30. Hashimoto Y, Tanaka M, Kishimoto H. Preparation,
characterisation and taste-masking properties of
polyvinylacetal diethylaminoacetate microspheres
containing trimebutine. J Pharm Pharmacol 2002; 54:
1323-8.

31. Patel AR, Vavia PR. Preparation and evaluation of
taste masked famotidine formulation using drug/beta-
cyclodextrin/polymer ternary complexation approach.
AAPS PharmSciTech 2008;9: 544-50.

32. Arima H, Higashi T, Motoyama K. Improvement of
the bitter taste of drugs by complexation with
cyclodextrins: applications, evaluations and
mechanisms. Ther Deliv 2012;3: 633-44.

33. Rajewski RA, Stella VJ. Pharmaceutical applications

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