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Taste masking in oral solid dosage forms

Tabla 7. Relación entre técnicas de evaluación del enmascaramiento de formas farmacéuticas sólidas orales, donde (+) apto, (-) no
apto, (-/+) apto pero sin reproducir fielmente la forma de administración.

                        Taste trial           Test de           Modelos        Velocidad de  Activación in    Lengua
                                          preferencia en  electrofisiológicos   disolución      vitro de    electrónica

                                             animales                                        proteínas G

Convencional no         (+)                 (+)            (+) (+) (-)                                      (-)
    recubierto

  Convencional          (+)                (-)             (+) (+) (-)                                      (-)
    recubierto
                        (+)                (-)             (+) (+) (-)                                      (-)
Gastrorresistente       (+)                (-)
    Sublingual          (+)               (-/+)            (+) (-) (-/+) (-/+)
                        (+)                (-)
Bucodispersable         (+)               (+)              (+)                 (+) (-/+)                    (-/+)
    Masticable          (+)               (+)
      Soluble           (+)               (+)              (-)                 (+) (-/+)                    (-/+)
   Efervescente
                                                           (+) (-) (+) (+)
   Dispersable
                                                           (+) (-) (+) (+)

8. AGRADECIMIENTOS                                         (+) (-) (+) (+)

    Los autores agradecen al Ministerio de Educación,      7. Shishu, Bhatti A, Singh T. Preparation of tablets rapidly
Cultura y Deporte la concesión de la ayuda para contratos       disintegrating in saliva containing bitter taste-masked
predoctorales de Formación del Profesorado Universitario        granules by compression method. Indian J Pharm Sci
a Juan Aparicio Blanco (Referencia FPU13/02325).                2007;69:80-4.

9. REFERENCIAS                                             8. Bandari S, Mittapalli RK, Gannu R, Rao YM.
                                                                Orodispersible tablets: An overview. Asian J Pharm
1. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast        2008; 2:2-11.

disintegrating          tablets:          developments,    9. Shukla D, Chakraborty S, Singh S, Mishra B. Mouth
                                                                Dissolving Tablets I: An Overview of Formulation
technologies,taste-masking and clinical studies. Crit           Technology. Sci Pharm 2009; 77:309-326.

Rev Ther Drug Carrier Syst 2004; 21: 433-76.               10. Shukla D, Chakraborty S, Singh S, Mishra B. Mouth
                                                                Dissolving Tablets II:An Overview of Evaluation
2. Parul BP. Fast Dissolving Drug Delivery Systems: An          Techniques. Sci Pharm 2009; 77:327–341.

Update. Pharmaceutical Reviews 2006;4.                     11. Yapar EA.Orally Disintegrating Tablets: An Overview.
                                                                J.App.Pharm.Sc 2014; 4:118-125.
3. Sohi H, Sultana Y, Khar RK. Taste masking
                                                           12. Douroumis D. Practical approaches of taste masking
technologies in oral pharmaceuticals: recent                    technologies in oral solid forms. Expert Opin Drug
                                                                Deliv 2007; 4: 417-426.
developments and approaches. Drug Dev Ind Pharm
                                                           13. Mennella JA, Beauchamp GK. Optimizing oral
2004; 30: 429-48.                                               medications for children. Clin Ther 2008; 30:2120-32.

4. Gittings S, Turnbull N, Roberts CJ, Gershkovich P.      14. Guyton C, Hall JE. The Chemical Senses – Taste and
     Dissolution methodology for taste masked oral dosage       Smell Textbook of Medical Physiology. 11th ed.
                                                                Hong Kong: W.D. Saunders Company 2007.
forms. J Control Release 2014; 173: 32-42.
                                                           15. Mennella JA, Spector AC, Reed DR, Coldwell SE. The
5. Joshi S, Petereit HU. Film coatings for taste masking        bad taste of medicines: overview of basic research on
                                                                bitter taste. Clin Ther 2013; 35:1225-46.
and moisture protection. Int J Pharm 2013;
                                                           16. Mojet J, Christ-Hazelhof E, Heidema J. Taste
457(2):395-406.                                                 perception with age: generic or specific losses in
                                                                threshold sensitivity to the five basic tastes?. Chem
6. Douroumis D. Orally disintegrating dosage forms and
     taste-masking Technologies 2010. Expert Opin Drug

Deliv 2011; 8: 665-75.

@Real Academia Nacional de Farmacia. Spain                                                                         127
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