Page 96 - 73_01

RUTH M. RISUEÑO y BALBINO ALARCÓN AN. R. ACAD. NAC. FARM.

AGRADECIMIENTOS

Deseamos agradecer el valioso trabajo del equipo técnico del
grupo. La investigación ha sido financiada por la Comisión Inter-
ministerial de Ciencia y Tecnología SAF2005-00937 (B. A.), el pro-
grama de Formación de Profesorado Universitario (R. M. R.) y la
Fundación Ramón Areces y el Banco Santander Central Hispano
(CBMSO).

BIBLIOGRAFÍA

(1) KUHNS, M. S.; DAVIS, M. M. and GARCÍA, K. C. (2006): Deconstructing the Form
(2) and Function of the TCR/CD3 Complex. Immunity 24: 133-139.
(3) KANE, L. P.; LIN, J. and WEISS, A. (2000): Signal transduction by the TCR for
antigen. Curr. Opin. Immunol. 12: 242-249.
(4) GIL, D.; GUTIÉRREZ, D. and ALARCON, B. (2001): Intracellular redistribution of
(5) nucleolin upon interaction with the CD3epsilon chain of the T cell receptor
complex. J. Biol. Chem. 276: 11174-11179.
(6) WERLEN, G. and PALMER, E. (2002): The T-cell receptor signalosome: a dyna-
(7) mic structure with expanding complexity. Curr. Opin. Immunol. 14: 299-305.
(8) GIL, D.; SCHAMEL, W. W.; MONTOYA, M.; SÁNCHEZ-MADRID, F. and ALARCON, B.
(9) (2002): Recruitment of Nck by CD3 epsilon reveals a ligand-induced confor-
mational change essential for T cell receptor signaling and synapse forma-
(10) tion. Cell. 109: 901-912.
STARR, T. K.; JAMESON, S. C. and HOGQUIST, K. A. (2003): Positive and negative
(11) selection of T cells. Annu. Rev. Immunol. 21: 139-176.
HOGQUIST, K. A.; BALDWIN, T. A. and JAMESON, S. C. (2005): Central tolerance:
(12) learning self-control in the thymus. Nat. Rev. Immunol. 5: 772-782.
SIGGS, O. M.; MAKAROFF, L. E. and LISTON, A. (2006): The why and how of
thymocyte negative selection. Curr. Opin. Immunol. 18: 175-183.
WERLEN, G.; HAUSMANN, B. and PALMER, E. (2000): A motif in the alphabeta
T-cell receptor controls positive selection by modulating ERK activity. Natu-
re. 406: 422-426.
MCCARTY, N.; PAUST, S.; IKIZAWA, K.; DAN, I.; LI, X. and CANTOR, H. (2005):
Signaling by the kinase MINK is essential in the negative selection of auto-
reactive thymocytes. Nat. Immunol. 6: 65-72.
RISUENO, R. M.; VAN SANTEN, H. M. and ALARCON, B. (2006): A conformational
change senses the strength of T cell receptor-ligand interaction during thy-
mic selection. Proc. Natl. Acad. Sci. USA. 103: 9625-9630.
HOGQUIST, K. A.; JAMESON, S. C.; HEATH, W. R.; HOWARD, J. L.; BEVAN, M. J. and
CARBONE, F. R. (1994): T cell receptor antagonist peptides induce positive
selection. Cell. 76: 17-27.

44