Page 58 - 82_03
P. 58

Arantxa Rodríguez Casado, Adolfo Toledano-Díaz, Adolfo Toledano

     reticulum stress. Proc Natl Acad Sci USA                     Velasco PT, Lambert MP, Viola KL, Zhao WQ,
     2011;108:2939-44.                                            Ferreira ST, Klein WL. Protection of synapses against
                                                                  Alzheimer's-linked toxins: insulin signaling prevents
62. Hoozemans JJ, Van Haastert ES, Nijholt DA,                    the pathogenic binding of Abeta oligomers. Proc Natl
     Rozemuller AJ, Eikelenboom P, Scheper W. The                 Acad Sci USA 2009;106:1971-6.
     unfolded protein response is activated in pretangle
     neurons in Alzheimer's disease hippocampus. Am J        69. Craft S. Alzheimer disease: Insulin resistance and AD-
     Pathol 2009;174:1241-51.                                     extending the translational path. Nat Rev Neurol
                                                                  2012;8:360-2.
63. Lourenco MV, Clarke JR, Frozza RL, Bomfim TR,
     Forny-Germano L, Batista AF, Sathler LB, Brito-         70. Moloney AM, Griffin RJ, Timmons S, O'Connor R,
     Moreira J, Amaral OB, Silva CA, Freitas-Correa L,            Ravid R, O'Neill C. Defects in IGF-1 receptor, insulin
     Espírito-Santo S, Campello-Costa P, Houzel JC, Klein         receptor and IRS-1/2 in Alzheimer's disease indicate
     WL, Holscher C, Carvalheira JB, Silva AM, Velloso            possible resistance to IGF-1 and insulin signalling.
     LA, Munoz DP, Ferreira ST, DeFelice FG. TNF-a                Neurobiol Aging 2010;31:224-43.
     mediates PKR-dependent memory impairment and
     brain IRS-1 inhibition induced by Alzheimer's ß-        71. Zhu X, Lee HG, Raina AK, Perry G, Smith MA. The
     amyloid oligomers in mice and monkeys. Cell Metab            role of mitogen-activated protein kinase pathways in
     2013;18:831-43.                                              Alzheimer's disease. Neurosignals 2002;11:270-81.

64. Banks WA. Blood-brain barrier transport of cytokines:    72. Miloso M, Scuteri A, Foudah D, Tredici G. MAPKs as
     a mechanism for neuropathology. Curr Pharm Des.              mediators of cell fate determination: an approach to
     2005;11:973-84.                                              neurodegenerative diseases. Curr Med Chem
                                                                  2008;15:538-48.
65. Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer
     R, Montine TJ, Craft S. Different patterns of cerebral  73. Kosicek M, Hecimovic S. Phospholipids and
     injury in dementia with or without diabetes. Arch            Alzheimer's disease: alterations, mechanisms and
     Neurol 2009;66:315-22. 8. Smith U. Abdominal                 potential biomarkers. Int J Mol Sci 2013;14:1310-22.
     obesity: a marker of ectopic fat accumulation. J Clin
     Invest 2015;125:1790-2.                                 74. Kaidanovich O, Eldar-Finkelman H. The role of
                                                                  glycogen synthase kinase-3 in insulin resistance and
66. Kitazawa M, Cheng D, Tsukamoto MR, Koike MA,                  type 2 diabetes. Expert Opin Ther Targets 2002;6:555-
     Wes PD, Vasilevko V, Cribbs DH, LaFerla FM.                  61.
     Blocking IL-1 signaling rescues cognition, attenuates
     tau pathology, and restores neuronal ß-catenin          75. Kim B, Feldman EL. Insulin resistance in the nervous
     pathway function in an Alzheimer's disease model. J          system. Trends Endocrinol Metab 2012;23:133-41.
     Immunol 2011;187:6539-49.
                                                             76. Bales KR. Brain lipid metabolism, apolipoprotein E
67. Sly LM, Krzesicki RF, Brashler JR, Buhl AE,                   and the pathophysiology of Alzheimer's disease.
     McKinley DD, Carter DB, Chin JE. Endogenous brain            Neuropharmacology 2010;59:295-302.
     cytokine mRNA and inflammatory responses to
     lipopolysaccharide are elevated in the Tg2576           77. Talbot K, Wang HY. The nature, significance, and
     transgenic mouse model of Alzheimer's disease. Brain         glucagon-like peptide-1 analog treatment of brain
     Res Bull 2001;56:581-8.                                      insulin resistance in Alzheimer's disease. Alzheimers
                                                                  Dement 2014;10:S12-25.
68. DeFelice FG, Vieira MN, Bomfim TR, Decker H,
                                                             78. Huang PL. A comprehensive definition for metabolic
                                                                  syndrome. Dis Model Mech 2009;2:231-7.

316 @Real Academia Nacional de Farmacia. Spain
   53   54   55   56   57   58   59   60   61   62   63