Page 57 - 82_03
P. 57
Obesity: a risk for Alzheimer's disease? I. Common molecular mechanisms
Alzheimer's disease, and insulin resistance in the endoplasmic reticulum stress in insulin resistance and
brain: progress, dilemmas, new opportunities, and a diabetes. J Biol Chem 2005;280:847-51 [Erratum in: J
hypothesis to tackle intersecting epidemics. J Biol Chem 2005;280:30648].
Alzheimers Dis 2011;25:29-41.
51. Lowell BB, Shulman GI. Mitochondrial dysfunction
37. Cheng Z, Tseng Y, White MF. Insulin signaling meets and type 2 diabetes. Science 2005;307:384-7.
mitochondria in metabolism. Trends Endocrinol
Metab 2010;21:589-98. 52. Vitale G, Salvioli S, Franceschi C. Oxidative stress and
the ageing endocrine system. Nat Rev Endocrinol
38. Samuel VT, Shulman GI. Mechanisms for insulin 2013;9:228-40.
resistance: common threads and missing links. Cell
2012;148:852-71. 53. Toledano A, Álvarez MI, Toledano-Díaz A,
Rodríguez-Arellano JJ. New concepts on the
39. Tang QQ, Lane MD. Adipogenesis: from stem cell to functionality of the nervous system: the revolution of
adipocyte. Annu Rev Biochem 2012;81:715-36. the glial cells. II. Glial responses keys in the
pathogenesis and treatment of diseases of SN. An Real
40. Gregor MF, Hotamisligil GS. Inflammatory Acad Farm 2016;82:51-67.
mechanisms in obesity. Annu Rev Immunol
2011;29:415-45. 54. Toledano A, Álvarez MI, Toledano-Díaz A.
Envejecimiento cerebral normal y patológico:
41. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a continuum fisiopatológico o dualidad de procesos
phenotypic switch in adipose tissue macrophage involutivos. An Real Acad Farm 2014;80:500-39.
polarization. J Clin Invest 2007;117:175-84.
55. Swardfager W, Lanctôt K, Rothenburg L, Wong A,
42. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka Cappell J, Herrmann N. A meta-analysis of cytokines
S, Segawa K, Furukawa S, Tochino Y, Komuro R, in Alzheimer's disease. Biol Psychiatry 2010;68:930-
Matsuda M, Shimomura I. Adipose tissue hypoxia in 41.
obesity and its impact on adipocytokine dysregulation.
Diabetes 2007;56:901-11. 56. Alcolea D, Martínez-Lage P, Sánchez-Juan P,
Olazarán J, Antúnez C, Izagirre A, Ecay-Torres M,
43. Ye J. Emerging role of adipose tissue hypoxia in Estanga A, Clerigué M, Guisasola MC, Sánchez Ruiz
obesity and insulin resistance. Int J Obes (Lond) D, Marín Muñoz J, Calero M, Blesa R, Clarimón J,
2009;33:54-66. Carmona-Iragui M, Morenas-Rodríguez E, Rodríguez-
Rodríguez E, Vázquez Higuera JL, Fortea J, Lleó A.
44. Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Amyloid precursor protein metabolism and
Combs TP, Rajala MW, Du X, Rollman B, Li W, inflammation markers in preclinical Alzheimer
Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, disease. Neurology 2015;85:626-33.
Brownlee M, Scherer PE. The hyperglycemia-induced
inflammatory response in adipocytes: the role of 57. Park KM, Bowers WJ. Tumor Necrosis Factor-alpha
reactive oxygen species. J Biol Chem 2005;280:4617- mediated signaling in neuronal homeostasis and
26. dysfunction. Cell Signal 2010;22:977-983.
45. Saltiel AR, Kahn CR. Insulin signalling and the 58. Bomfim TR, Forny-Germano L, Sathler LB, Brito-
regulation of glucose and lipid metabolism. Nature. Moreira J, Houzel JC, Decker H, Silverman MA, Kazi
2001;414:799-806. H, Melo HM, McClean PL, Holscher C, Arnold SE,
Talbot K, Klein WL, Munoz DP, Ferreira ST, De
46. Sykiotis GP, Papavassiliou AG. Serine Felice FG. An anti-diabetes agent protects the mouse
phosphorylation of insulin receptor substrate-1: a brain from defective insulin signaling caused by
novel target for the reversal of insulin resistance. Mol Alzheimer's disease- associated Aß oligomers. J Clin
Endocrinol 2001;15:1864-9. Invest 2012;122:1339-53.
47. Weisberg SP, McCann D, Desai M, Rosenbaum M, 59. Costello DA, Claret M, Al-Qassab H, Plattner F, Irvine
Leibel RL, Ferrante AW Jr. Obesity is associated with EE, Choudhury AI, Giese KP, Withers DJ, Pedarzani
macrophage accumulation in adipose tissue. J Clin P. Brain deletion of insulin receptor substrate 2
Invest 2003;112:1796-808. disrupts hippocampal synaptic plasticity and
metaplasticity. PloS One 2012;7,e31124.
48. Wellen KE, Hotamisligil GS. Inflammation, stress, and
diabetes. J Clin Invest 2005;115:1111-9. 60. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH,
Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla
49. Holland WL, Bikman BT, Wang LP, Yuguang G, KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE,
Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg Morton GJ, Horvath TL, Baskin DG, Tschöp MH,
DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers Schwartz MW. Obesity is associated with
SA. Lipid-induced insulin resistance mediated by the hypothalamic injury in rodents and humans. J Clin
proinflammatory receptor TLR4 requires saturated Invest 2012;122:153-62.
fatty acid-induced ceramide biosynthesis in mice. J
Clin Invest 2011;121:1858-70. 61. Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y,
Cai D. Neural dysregulation of peripheral insulin
50. Nakatani Y, Kaneto H, Kawamori D, Yoshiuchi K, action and blood pressure by brain endoplasmic
Hatazaki M, Matsuoka TA, Ozawa K, Ogawa S, Hori
M, Yamasaki Y, Matsuhisa M. Involvement of
@Real Academia Nacional de Farmacia. Spain 315