Page 94 - 82_02
P. 94
New therapeutic targets for the treatment of insulin resistance…
38. Huang W, Metlakunta A, Dedousis N, Zhang P, through an IL-10 STAT3-dependent mechanism.
Sipula I, Dube JJ, et al. Depletion of liver Kupffer Diabetes. 2014;63(2):456-70.
cells prevents the development of diet-induced hepatic
steatosis and insulin resistance. Diabetes. 51. Delibegovic M, Bence KK, Mody N, Hong EG, Ko
2010;59(2):347-57. HJ, Kim JK, et al. Improved glucose homeostasis in
mice with muscle-specific deletion of protein-tyrosine
39. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, phosphatase 1B. Mol Cell Biol. 2007;27(21):7727-34.
Long JM, et al. IKK-beta links inflammation to
obesity-induced insulin resistance. Nat Med. 52. Elchebly M, Payette P, Michaliszyn E, Cromlish W,
2005;11(2):191-8. Collins S, Loy AL, et al. Increased insulin sensitivity
and obesity resistance in mice lacking the protein
40. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, tyrosine phosphatase-1B gene. Science.
Vats D, Morel CR, Goforth MH, et al. Alternative M2 1999;283(5407):1544-8.
activation of Kupffer cells by PPARdelta ameliorates
obesity-induced insulin resistance. Cell Metab. 53. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL,
2008;7(6):496-507. Zabolotny JM, et al. Increased energy expenditure,
decreased adiposity, and tissue-specific insulin
41. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes sensitivity in protein-tyrosine phosphatase 1B-
in signalling pathways: insights into insulin action. deficient mice. Mol Cell Biol. 2000;20(15):5479-89.
Nat Rev Mol Cell Biol. 2006;7(2):85-96.
54. Delibegovic M, Zimmer D, Kauffman C, Rak K,
42. Camell C, Smith CW. Dietary oleic acid increases m2 Hong EG, Cho YR, et al. Liver-specific deletion of
macrophages in the mesenteric adipose tissue. PLoS protein-tyrosine phosphatase 1B (PTP1B) improves
One. 2013;8(9):e75147. metabolic syndrome and attenuates diet-induced
endoplasmic reticulum stress. Diabetes.
43. Ruddock MW, Stein A, Landaker E, Park J, Cooksey 2009;58(3):590-9.
RC, McClain D, et al. Saturated fatty acids inhibit
hepatic insulin action by modulating insulin receptor 55. Owen C, Lees EK, Grant L, Zimmer DJ, Mody N,
expression and post-receptor signalling. J Biochem. Bence KK, et al. Inducible liver-specific knockdown
2008;144(5):599-607. of protein tyrosine phosphatase 1B improves glucose
and lipid homeostasis in adult mice. Diabetologia.
44. Lei H, Lu F, Dong H, Xu L, Wang J, Zhao Y, et al. 2013;56(10):2286-96.
Genistein reverses free fatty acid-induced insulin
resistance in HepG2 hepatocytes through targeting 56. Gonzalez-Rodriguez A, Mas Gutierrez JA, Sanz-
JNK. J Huazhong Univ Sci Technolog Med Sci. Gonzalez S, Ros M, Burks DJ, Valverde AM.
2011;31(2):185-9. Inhibition of PTP1B restores IRS1-mediated hepatic
insulin signaling in IRS2-deficient mice. Diabetes.
45. Malhi H, Gores GJ. Molecular mechanisms of 2010;59(3):588-99.
lipotoxicity in nonalcoholic fatty liver disease. Semin
Liver Dis. 2008;28(4):360-9. 57. Bence KK, Delibegovic M, Xue B, Gorgun CZ,
Hotamisligil GS, Neel BG, et al. Neuronal PTP1B
46. Listenberger LL, Han X, Lewis SE, Cases S, Farese regulates body weight, adiposity and leptin action. Nat
RV, Jr., Ory DS, et al. Triglyceride accumulation Med. 2006;12(8):917-24.
protects against fatty acid-induced lipotoxicity. Proc
Natl Acad Sci U S A. 2003;100(6):3077-82. 58. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad
A, Haj F, Wang Y, Minokoshi Y, et al. PTP1B
47. Mei S, Ni HM, Manley S, Bockus A, Kassel KM, regulates leptin signal transduction in vivo. Dev Cell.
Luyendyk JP, et al. Differential roles of unsaturated 2002;2(4):489-95.
and saturated fatty acids on autophagy and apoptosis
in hepatocytes. J Pharmacol Exp Ther. ?
2011;339(2):487-98.
48. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE,
Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B
expression is induced by inflammation in vivo. J Biol
Chem. 2008;283(21):14230-41.
49. Gonzalez-Rodriguez A, Mas-Gutierrez JA, Mirasierra
M, Fernandez-Perez A, Lee YJ, Ko HJ, et al. Essential
role of protein tyrosine phosphatase 1B in obesity-
induced inflammation and peripheral insulin
resistance during aging. Aging Cell. 2012;11(2):284-
96.
50. Grant L, Shearer KD, Czopek A, Lees EK, Owen C,
Agouni A, et al. Myeloid-cell protein tyrosine
phosphatase-1B deficiency in mice protects against
high-fat diet and lipopolysaccharide-induced
inflammation, hyperinsulinemia, and endotoxemia
@Real Academia Nacional de Farmacia. Spain 209
