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New therapeutic targets for the treatment of insulin resistance…
Figure 9. A. Schematic representation of palmitate-induced M1 polarization of macrophages that leads to a negative cross-talk with
hepatic insulin signaling through decreasing IR and IRS1. B. Schematic representation of the beneficial effects of oleate in switching
macrophages polarization by inducing M2 state to enhance insulin sensitivity in hepatocytes.
4. CONCLUSIONS
- Palmitate treated macrophages/Kuppfer cells have
increased expression of proinflammatory cytokines.
- The CM-P/CMK-P leads to activation of stress
pathways and result in insulin resistance in human and
murine hepatocytes.
- Oleate treated macrophages/Kuppfer cells express
markers of antiinflammatory activity.
- The CM-O/CMK-O produces a hypersensitivity to
insulin in human and murine hepatocytes probably by
lower levels of PTP1B.
5. ACKNOWLEDGEMENTS
The authors acknowledge financial support from grants
SAF2012-33283 (MINECO, Spain), Comunidad de
Madrid S2010/BMD-2423 (Spain), Centro de
Investigación Biomédica en Red de Diabetes y
Enfermedades Metabólicas Asociadas (CIBEDEM,
Instituto Carlos III, Spain).
This work is dedicated in memory to Professor
Margarita Lorenzo who was a member of the RANF.
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