Page 24 - 82_02

22. Engberding N, San Martín A, Martin-Garrido A, Koga Almudena Gómez-Hernández et al.
M, Pounkova L, Lyons E, Lassègue B, Griendling Insulin-like growth factor II plays a central role in
KK. Insulin-like growth factor-1 receptor expression atherosclerosis in a mouse model. J Biol Chem
masks the antiinflammatory and glucose uptake 2002;277:4505-11.
capacity of insulin in vascular smooth muscle cells. ?
Arterioscler Thromb Vasc Biol 2009;29:408-15.
@Real Academia Nacional de Farmacia. Spain
23. Bartolomé A, Guillén C, Benito M. Role of the TSC1-
TSC2 complex in the integration of insulin and
glucose signaling involved in pancreatic beta-cell
proliferation. Endocrinology 2010;151:3084-94.

24. Ross R. The pathogenesis of atherosclerosis: a
perspective for the 1990s. Nature 1993;362: 801-9.

25. Kahn AM, Allen JC, Seidel CL, Zhang S. Insulin
inhibits migration of vascular smooth muscle cells
with inducible nitric oxide synthase. Hypertension
2000;35:303-6.

26. Abhijit S, Bhaskaran R, Narayanasamy A,
Chakroborty A, Manickam N, Dixit M, Mohan V,
Balasubramanyam M. Hyperinsulinemia-induced
vascular smooth muscle cell (VSMC) migration and
proliferation is mediated by converging mechanisms
of mitochondrial dysfunction and oxidative stress.
Mol Cell Biochem 2013;373:95-105.

27. Bornfeldt KE, Raines EW, Nakano T, Graves LM,
Krebs EG, Ross R. Insulin-like growth factor-I and
platelet-derived growth factor-BB induce directed
migration of human arterial smooth muscle cells via
signaling pathways that are distinct from those of
proliferation. J Clin Invest 1994;93:1266-74.

28. Duan C, Bauchat JR, Hsieh T. Phosphatidylinositol 3-
kinase is required for insulin-like growth factor-I-
induced vascular smooth muscle cell proliferation and
migration. Circ Res 2000;86:15-23.

29. Polanco JI, Albajar M, Pocoví M, Rodríguez Rey JC.
Induction of insulin-like growth factor receptor (IGF
IR) mRNA levels by low density lipoproteins.
Biochem Biophys Res Commun 1996;226: 917-22.

30. Ross R. Cellular and molecular studies of
atherogenesis. Atherosclerosis 1997;131 Suppll, S3-4.

31. Schwartz SM. The intima: a new soil. Circ Res
1999;85:877-9.

32. Hsueh WA, Jackson S, Law RE. Control of vascular
cell proliferation and migration by PPAR-gamma: a
new approach to the macrovascular complications of
diabetes. Diabetes Care 2001;24:392-7.

33. Faries PL, Rohan DI, Takahara H, Wyers MC,
Contreras MA, Quist WC, King GL, Logerfo FW.
Human vascular smooth muscle cells of diabetic
origin exhibit increased proliferation, adhesion, and
migration. J Vasc Surg 2001;33:601-7.

34. Zhang L, Peppel K, Sivashanmugam P, Orman ES,
Brian L, Exum ST, Freedman NJ. Expression of tumor
necrosis factor receptor-1 in arterial wall cells
promotes atherosclerosis. Arterioscler Thromb Vasc
Biol 2007;27:1087-94.

35. Zaina S, Pettersson L, Ahrén B, Brånén L, Hassan
AB, Lindholm M, Mattsson R, Thyberg J, Nilsson J.

142