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Role of insulin receptor A isoform and IGF-1R in the development of atherosclerotic plaque
4. CONCLUSIONES hyperplasia induced by hepatic insulin resistance: role
of a liver-pancreas endocrine axis through insulin
Nuestros datos sugieren que la isoforma A del receptor receptor A isoform. Diabetes 2009;58:820-8.
de la insulina y la formación de receptores híbridos con
TNF-R1 o IGF-1R, confieren una ventaja proliferativa a 10. Sciacca L, Prisco M, Wu A, Belfiore A, Vigneri R,
las células de músculo liso vascular, principalmente en Baserga R. Signaling differences from the A and B
respuesta a TNF-a o IGF-2. Además, la migración de las isoforms of the insulin receptor (IR) in 32D cells in
VSMCs inducida por insulina, IGF-1 e IGF-2, podría estar the presence or absence of IR substrate-1.
favorecida por el aumento de la expresión de IRA e IGF- Endocrinology 2003;144:2650-8.
1R. Por ello sugerimos que la IRA confiere a las células de
músculo liso vascular una ventaja proliferativa y 11. Pandini G, Vigneri R, Costantino A, Frasca F,
migratoria en respuesta a distintas señales inflamatorias y Ippolito A, Fujita-Yamaguchi Y, Siddle K, Goldfine
siendo claves para el crecimiento de la placa durante las ID, Belfiore A. Insulin and insulin-like growth factor-I
fases iniciales del proceso aterogénico. (IGF-I) receptor overexpression in breast cancers
leads to insulin/IGF-I hybrid receptor overexpression:
5. AGRADECIMIENTOS evidence for a second mechanism of IGF-I signaling.
Clin Cancer Res 1999;5:1935-44.
Este trabajo ha sido financiado por los proyectos
SAF2007/60058, SAF2008/00031 y SAF2011/22555 del 12. Sciacca L, Costantino A, Pandini G, Mineo R, Frasca
Ministerio de Ciencia e Innovación, Comunidad de Madrid F, Scalia P, Sbraccia P, Goldfine ID, Vigneri R,
(S2010/BMD-2423) y CIBER de Diabetes y Enfermedades Belfiore A. Insulin receptor activation by IGF-II in
Metabólicas Asociadas (CIBERDEM, ISCIII, Spain), breast cancers: evidence for a new autocrine/paracrine
Spain. Quería agradecer a Gema García y Silvia Fernández mechanism. Oncogene 1999;18:2471-9.
por su asistencia técnica.
13. Vella V, Sciacca L, Pandini G, Mineo R, Squatrito S,
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@Real Academia Nacional de Farmacia. Spain 141
