Page 43 - 80_01
P. 43

Elvira	
  López-­-Oliva	
  Muñoz,	
  Emilia	
  Muñoz	
  Martínez	
  

	
  

        71. Targher,	
   G.,	
   Bertolini,	
   L.,	
   Scala,	
   L.	
   y	
   col.	
   2004.	
   Decreased	
   plasma	
   adiponectin	
  

        concentrations	
   are	
   closely	
   associated	
   with	
   nonalcoholic	
   hepatic	
   steatosis	
   in	
   obese	
  
        individuals.	
  Clin	
  Endocrinol	
  (Oxf)	
  61,	
  700-­-703.	
  

        72. Bertolani,	
   C.,	
   Sancho-­-Bru,	
   P.,	
   Failli,	
   P.	
   y	
   col.	
   2006.	
   Resistin	
   as	
   an	
   intrahepatic	
   cytokine:	
  

        overexpression	
  during	
  chronic	
  injury	
  and	
  induction	
  of	
  proinflammatory	
  actions	
  in	
  hepatic	
  

        stellate	
  cells.	
  Am	
  J	
  Pathol	
  169,	
  2042-­-2053.	
  

        73. Marra,	
   F.,	
   2007.	
   Leptin	
   and	
   liver	
   tissue	
   repair:	
   do	
   rodent	
   models	
   provide	
   the	
   answers?	
   J	
  

        Hepatol	
  46,	
  12-­-18.	
  
        74. Ota,	
   T.,	
   Takamura,	
   T.,	
   Kurita,	
   S.	
   y	
   col.	
   2007.	
   Insulin	
   resistance	
   accelerates	
   a	
   dietary	
   rat	
  

        model	
  of	
  nonalcoholic	
  steatohepatitis.	
  Gastroenterology	
  132,	
  282-­-293.	
  

        75. 	
    Fuchs,	
  M.,	
  Sanyal,	
  A.J.,	
  2012.	
  Lipotoxicity	
  in	
  NASH.	
  J	
  Hepatol	
  56,	
  291-­-293.	
  

        76. Hotta,	
  K.,	
  Yoneda,	
  M.,	
  Hyogo,	
  H.	
  y	
  col.	
  2010.	
  Association	
  of	
  the	
  rs738409	
  polymorphism	
  in	
  

        PNPLA3	
   with	
   liver	
   damage	
   and	
   the	
   development	
   of	
   nonalcoholic	
   fatty	
   liver	
   disease.	
   BMC	
  

        Med	
  Genet	
  11,	
  172.	
  

        77. Petta,	
   S.,	
   Muratore,	
   C.,	
   Craxì,	
   A.,	
   2009.	
   Non-­-alcoholic	
   fatty	
   liver	
   disease	
   pathogenesis:	
   the	
  
        present	
  and	
  the	
  future.	
  Dig	
  Liver	
  Dis	
  41,	
  615-­-625.	
  

        78. Horton,	
  J.D.,	
  Goldstein,	
  J.L.,	
  Brown,	
  M.S.,	
  2002.	
  SREBPs:	
  activators	
  of	
  the	
  complete	
  program	
  

        of	
  cholesterol	
  and	
  fatty	
  acid	
  synthesis	
  in	
  the	
  liver.	
  J	
  Clin	
  Invest	
  109,	
  1125-­-1131.	
  

        79. Hua,	
  X.,	
  Wu,	
  J.,	
  Goldstein,	
  J.L.,	
  Brown,	
  M.S.,	
  Hobbs,	
  H.H.,	
  1995.	
  Structure	
  of	
  the	
  human	
  gene	
  

        encoding	
   sterol	
   regulatory	
   element	
   binding	
   protein-­-1	
   (SREBF1)	
   and	
   localization	
   of	
  

        SREBF1	
  and	
  SREBF2	
  to	
  chromosomes	
  17p11.2	
  and	
  22q13.	
  Genomics	
  25,	
  667-­-673.	
  

        80. Shimomura,	
  I.,	
  Shimano,	
  H.,	
  Horton,	
  J.D.	
  y	
  col.	
  1997.	
  Differential	
  expression	
  of	
  exons	
  1a	
  and	
  
        1c	
  in	
  mRNAs	
  for	
  sterol	
  regulatory	
  element	
  binding	
  protein-­-1	
  in	
  human	
  and	
  mouse	
  organs	
  

        and	
  cultured	
  cells.	
  J	
  Clin	
  Invest	
  99,	
  838-­-845.	
  

        81. Foretz,	
   M.,	
   Guichard,	
   C.,	
   Ferré,	
   P.,	
   Foufelle,	
   F.,	
   1999.	
   Sterol	
   regulatory	
   element	
   binding	
  

        protein-­-1c	
   is	
   a	
   major	
   mediator	
   of	
   insulin	
   action	
   on	
   the	
   hepatic	
   expression	
   of	
   glucokinase	
  

        and	
  lipogenesis-­-related	
  genes.	
  Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  96,	
  12737-­-12742.	
  

        82. Sato,	
  R.,	
  2010.	
  Sterol	
  metabolism	
  and	
  SREBP	
  activation.	
  Arch	
  Biochem	
  Biophys	
  501,	
  177-­-
        181.	
  

        83. Daemen,	
  S.,	
  Kutmon,	
  M.,	
  Evelo,	
  C.T.,	
  2013.	
  A	
  pathway	
  approach	
  to	
  investigate	
  the	
  function	
  

        and	
  regulation	
  of	
  SREBPs.	
  Genes	
  Nutr	
  8,	
  289-­-300.	
  

        84. Jeon,	
   T.I.,	
   Osborne,	
   T.F.,	
   2012.	
   SREBPs:	
   metabolic	
   integrators	
   in	
   physiology	
   and	
  

        metabolism.	
  Trends	
  Endocrinol	
  Metab	
  23,	
  65-­-72.	
  

        85. Bennett,	
   M.K.,	
   Osborne,	
   T.F.,	
   2000.	
   Nutrient	
   regulation	
   of	
   gene	
   expression	
   by	
   the	
   sterol	
  

        regulatory	
   element	
   binding	
   proteins:	
   increased	
   recruitment	
   of	
   gene-­-specific	
   coregulatory	
  
        factors	
   and	
   selective	
   hyperacetylation	
   of	
   histone	
   H3	
   in	
   vivo.	
   Proc	
   Natl	
   Acad	
   Sci	
   U	
   S	
   A	
   97,	
  

        6340-­-6344.	
  

        86. Lin,	
   J.,	
   Yang,	
   R.,	
   Tarr,	
   P.T.	
   y	
   col.	
   2005.	
   Hyperlipidemic	
   effects	
   of	
   dietary	
   saturated	
   fats	
  

        mediated	
  through	
  PGC-­-1beta	
  coactivation	
  of	
  SREBP.	
  Cell	
  120,	
  261-­-273.	
  

        87. Li,	
  S.,	
  Brown,	
  M.S.,	
  Goldstein,	
  J.L.,	
  2010.	
  Bifurcation	
  of	
  insulin	
  signaling	
  pathway	
  in	
  rat	
  liver:	
  

        mTORC1	
   required	
   for	
   stimulation	
   of	
   lipogenesis,	
   but	
   not	
   inhibition	
   of	
   gluconeogenesis.	
  
        Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  107,	
  3441-­-3446.	
  

        88. Shimomura,	
   I.,	
   Bashmakov,	
   Y.,	
   Horton,	
   J.D.,	
   1999.	
   Increased	
   levels	
   of	
   nuclear	
   SREBP-­-1c	
  

        associated	
   with	
   fatty	
   livers	
   in	
   two	
   mouse	
   models	
   of	
   diabetes	
   mellitus.	
   J	
   Biol	
   Chem	
   274,	
  

        30028-­-30032.	
  

        89. Düvel,	
   K.,	
   Yecies,	
   J.L.,	
   Menon,	
   S.	
   y	
   col.	
   2010.	
   Activation	
   of	
   a	
   metabolic	
   gene	
   regulatory	
  

        network	
  downstream	
  of	
  mTOR	
  complex	
  1.	
  Mol	
  Cell	
  39,	
  171-­-183.	
  

        90. Yellaturu,	
  C.R.,	
  Deng,	
  X.,	
  Park,	
  E.A.	
  y	
  col.	
  2009.	
  Insulin	
  enhances	
  the	
  biogenesis	
  of	
  nuclear	
  
        sterol	
   regulatory	
   element-­-binding	
   protein	
   (SREBP)-­-1c	
   by	
   posttranscriptional	
   down-­-

        regulation	
   of	
   Insig-­-2A	
   and	
   its	
   dissociation	
   from	
   SREBP	
   cleavage-­-activating	
   protein	
  

        (SCAP).SREBP-­-1c	
  complex.	
  J	
  Biol	
  Chem	
  284,	
  31726-­-31734.	
  

        91. Peterson,	
   T.R.,	
   Sengupta,	
   S.S.,	
   Harris,	
   T.E.	
   y	
   col.	
   2011.	
   mTOR	
   complex	
   1	
   regulates	
   lipin	
   1	
  

        localization	
  to	
  control	
  the	
  SREBP	
  pathway.	
  Cell	
  146,	
  408-­-420.	
  

        92. Willy,	
   P.J.,	
   Mangelsdorf,	
   D.J.,	
   1997.	
   Unique	
   requirements	
   for	
   retinoid-­-dependent	
  

        transcriptional	
  activation	
  by	
  the	
  orphan	
  receptor	
  LXR.	
  Genes	
  Dev	
  11,	
  289-­-298.	
  
        93. Yoshikawa,	
   T.,	
   Shimano,	
   H.,	
   Amemiya-­-Kudo,	
   M.	
   y	
   col.	
   2001.	
   Identification	
   of	
   liver	
   X	
  

        receptor-­-retinoid	
   X	
   receptor	
   as	
   an	
   activator	
   of	
   the	
   sterol	
   regulatory	
   element-­-binding	
  

        protein	
  1c	
  gene	
  promoter.	
  Mol	
  Cell	
  Biol	
  21,	
  2991-­-3000.	
  

42	
  

	
  
   38   39   40   41   42   43   44   45   46   47   48