Page 43 - 80_01
P. 43
Elvira
López--Oliva
Muñoz,
Emilia
Muñoz
Martínez
71. Targher,
G.,
Bertolini,
L.,
Scala,
L.
y
col.
2004.
Decreased
plasma
adiponectin
concentrations
are
closely
associated
with
nonalcoholic
hepatic
steatosis
in
obese
individuals.
Clin
Endocrinol
(Oxf)
61,
700--703.
72. Bertolani,
C.,
Sancho--Bru,
P.,
Failli,
P.
y
col.
2006.
Resistin
as
an
intrahepatic
cytokine:
overexpression
during
chronic
injury
and
induction
of
proinflammatory
actions
in
hepatic
stellate
cells.
Am
J
Pathol
169,
2042--2053.
73. Marra,
F.,
2007.
Leptin
and
liver
tissue
repair:
do
rodent
models
provide
the
answers?
J
Hepatol
46,
12--18.
74. Ota,
T.,
Takamura,
T.,
Kurita,
S.
y
col.
2007.
Insulin
resistance
accelerates
a
dietary
rat
model
of
nonalcoholic
steatohepatitis.
Gastroenterology
132,
282--293.
75.
Fuchs,
M.,
Sanyal,
A.J.,
2012.
Lipotoxicity
in
NASH.
J
Hepatol
56,
291--293.
76. Hotta,
K.,
Yoneda,
M.,
Hyogo,
H.
y
col.
2010.
Association
of
the
rs738409
polymorphism
in
PNPLA3
with
liver
damage
and
the
development
of
nonalcoholic
fatty
liver
disease.
BMC
Med
Genet
11,
172.
77. Petta,
S.,
Muratore,
C.,
Craxì,
A.,
2009.
Non--alcoholic
fatty
liver
disease
pathogenesis:
the
present
and
the
future.
Dig
Liver
Dis
41,
615--625.
78. Horton,
J.D.,
Goldstein,
J.L.,
Brown,
M.S.,
2002.
SREBPs:
activators
of
the
complete
program
of
cholesterol
and
fatty
acid
synthesis
in
the
liver.
J
Clin
Invest
109,
1125--1131.
79. Hua,
X.,
Wu,
J.,
Goldstein,
J.L.,
Brown,
M.S.,
Hobbs,
H.H.,
1995.
Structure
of
the
human
gene
encoding
sterol
regulatory
element
binding
protein--1
(SREBF1)
and
localization
of
SREBF1
and
SREBF2
to
chromosomes
17p11.2
and
22q13.
Genomics
25,
667--673.
80. Shimomura,
I.,
Shimano,
H.,
Horton,
J.D.
y
col.
1997.
Differential
expression
of
exons
1a
and
1c
in
mRNAs
for
sterol
regulatory
element
binding
protein--1
in
human
and
mouse
organs
and
cultured
cells.
J
Clin
Invest
99,
838--845.
81. Foretz,
M.,
Guichard,
C.,
Ferré,
P.,
Foufelle,
F.,
1999.
Sterol
regulatory
element
binding
protein--1c
is
a
major
mediator
of
insulin
action
on
the
hepatic
expression
of
glucokinase
and
lipogenesis--related
genes.
Proc
Natl
Acad
Sci
U
S
A
96,
12737--12742.
82. Sato,
R.,
2010.
Sterol
metabolism
and
SREBP
activation.
Arch
Biochem
Biophys
501,
177--
181.
83. Daemen,
S.,
Kutmon,
M.,
Evelo,
C.T.,
2013.
A
pathway
approach
to
investigate
the
function
and
regulation
of
SREBPs.
Genes
Nutr
8,
289--300.
84. Jeon,
T.I.,
Osborne,
T.F.,
2012.
SREBPs:
metabolic
integrators
in
physiology
and
metabolism.
Trends
Endocrinol
Metab
23,
65--72.
85. Bennett,
M.K.,
Osborne,
T.F.,
2000.
Nutrient
regulation
of
gene
expression
by
the
sterol
regulatory
element
binding
proteins:
increased
recruitment
of
gene--specific
coregulatory
factors
and
selective
hyperacetylation
of
histone
H3
in
vivo.
Proc
Natl
Acad
Sci
U
S
A
97,
6340--6344.
86. Lin,
J.,
Yang,
R.,
Tarr,
P.T.
y
col.
2005.
Hyperlipidemic
effects
of
dietary
saturated
fats
mediated
through
PGC--1beta
coactivation
of
SREBP.
Cell
120,
261--273.
87. Li,
S.,
Brown,
M.S.,
Goldstein,
J.L.,
2010.
Bifurcation
of
insulin
signaling
pathway
in
rat
liver:
mTORC1
required
for
stimulation
of
lipogenesis,
but
not
inhibition
of
gluconeogenesis.
Proc
Natl
Acad
Sci
U
S
A
107,
3441--3446.
88. Shimomura,
I.,
Bashmakov,
Y.,
Horton,
J.D.,
1999.
Increased
levels
of
nuclear
SREBP--1c
associated
with
fatty
livers
in
two
mouse
models
of
diabetes
mellitus.
J
Biol
Chem
274,
30028--30032.
89. Düvel,
K.,
Yecies,
J.L.,
Menon,
S.
y
col.
2010.
Activation
of
a
metabolic
gene
regulatory
network
downstream
of
mTOR
complex
1.
Mol
Cell
39,
171--183.
90. Yellaturu,
C.R.,
Deng,
X.,
Park,
E.A.
y
col.
2009.
Insulin
enhances
the
biogenesis
of
nuclear
sterol
regulatory
element--binding
protein
(SREBP)--1c
by
posttranscriptional
down--
regulation
of
Insig--2A
and
its
dissociation
from
SREBP
cleavage--activating
protein
(SCAP).SREBP--1c
complex.
J
Biol
Chem
284,
31726--31734.
91. Peterson,
T.R.,
Sengupta,
S.S.,
Harris,
T.E.
y
col.
2011.
mTOR
complex
1
regulates
lipin
1
localization
to
control
the
SREBP
pathway.
Cell
146,
408--420.
92. Willy,
P.J.,
Mangelsdorf,
D.J.,
1997.
Unique
requirements
for
retinoid--dependent
transcriptional
activation
by
the
orphan
receptor
LXR.
Genes
Dev
11,
289--298.
93. Yoshikawa,
T.,
Shimano,
H.,
Amemiya--Kudo,
M.
y
col.
2001.
Identification
of
liver
X
receptor--retinoid
X
receptor
as
an
activator
of
the
sterol
regulatory
element--binding
protein
1c
gene
promoter.
Mol
Cell
Biol
21,
2991--3000.
42