Page 48 - 80_01
P. 48

SREBP-­-1c,	
  ChREBP	
  y	
  LXR…	
  

	
  

     178. Ross,	
   S.E.,	
   Erickson,	
   R.L.,	
   Gerin,	
   I.	
   y	
   col.	
   2002.	
   Microarray	
   analyses	
   during	
  
          adipogenesis:	
  understanding	
  the	
  effects	
  of	
  Wnt	
  signaling	
  on	
  adipogenesis	
  and	
  the	
  roles	
  of	
  
          liver	
  X	
  receptor	
  alpha	
  in	
  adipocyte	
  metabolism.	
  Mol	
  Cell	
  Biol	
  22,	
  5989-­-5999.	
  

     179. Dalen,	
   K.T.,	
   Ulven,	
   S.M.,	
   Bamberg,	
   K.	
   y	
   col.	
   2003.	
   Expression	
   of	
   the	
   insulin-­-
          responsive	
   glucose	
   transporter	
   GLUT4	
   in	
   adipocytes	
   is	
   dependent	
   on	
   liver	
   X	
   receptor	
  
          alpha.	
  J	
  Biol	
  Chem	
  278,	
  48283-­-48291.	
  

     180. Gerin,	
   I.,	
   Dolinsky,	
   V.W.,	
   Shackman,	
   J.G.	
   y	
   col.	
   2005.	
   LXRbeta	
   is	
   required	
   for	
  
          adipocyte	
   growth,	
   glucose	
   homeostasis,	
   and	
   beta	
   cell	
   function.	
   J	
   Biol	
   Chem	
   280,	
   23024-­-
          23031.	
  

     181. Pettersson,	
  A.M.,	
  Stenson,	
  B.M.,	
  Lorente-­-Cebrián,	
  S.	
  y	
  col.	
  2013.	
  LXR	
  is	
  a	
  negative	
  
          regulator	
  of	
  glucose	
  uptake	
  in	
  human	
  adipocytes.	
  Diabetologia	
  56,	
  2044-­-2054.	
  

     182. Zitzer,	
  H.,	
  Wente,	
  W.,	
  Brenner,	
  M.B.	
  y	
  col.	
  2006.	
  Sterol	
  regulatory	
  element-­-binding	
  
          protein	
  1	
  mediates	
  liver	
  X	
  receptor-­-beta-­-induced	
  increases	
  in	
  insulin	
  secretion	
  and	
  insulin	
  
          messenger	
  ribonucleic	
  acid	
  levels.	
  Endocrinology	
  147,	
  3898-­-3905.	
  

     183. Choe,	
   S.S.,	
   Choi,	
   A.H.,	
   Lee,	
   J.W.	
   y	
   col.	
   2007.	
   Chronic	
   activation	
   of	
   liver	
   X	
   receptor	
  
          induces	
   beta-­-cell	
   apoptosis	
   through	
   hyperactivation	
   of	
   lipogenesis:	
   liver	
   X	
   receptor-­-
          mediated	
  lipotoxicity	
  in	
  pancreatic	
  beta-­-cells.	
  Diabetes	
  56,	
  1534-­-1543.	
  

     184. López,	
   J.M.,	
   Bennett,	
   M.K.,	
   Sanchez,	
   H.B.	
   y	
   col.	
   1996.	
   Sterol	
   regulation	
   of	
   acetyl	
  
          coenzyme	
   A	
   carboxylase:	
   a	
   mechanism	
   for	
   coordinate	
   control	
   of	
   cellular	
   lipid.	
   Proc	
   Natl	
  
          Acad	
  Sci	
  U	
  S	
  A	
  93,	
  1049-­-1053.	
  

     185. Tabor,	
   D.E.,	
   Kim,	
   J.B.,	
   Spiegelman,	
   B.M.,	
   Edwards,	
   P.A.,	
   1998.	
   Transcriptional	
  
          activation	
   of	
   the	
   stearoyl-­-CoA	
   desaturase	
   2	
   gene	
   by	
   sterol	
   regulatory	
   element-­-binding	
  
          protein/adipocyte	
   determination	
   and	
   differentiation	
   factor	
   1.	
   J	
   Biol	
   Chem	
   273,	
   22052-­-
          22058.	
  

     186. Joseph,	
   S.B.,	
   Laffitte,	
   B.A.,	
   Patel,	
   P.H.	
   y	
   col.	
   2002.	
   Direct	
   and	
   indirect	
   mechanisms	
  
          for	
  regulation	
  of	
  fatty	
  acid	
  synthase	
  gene	
  expression	
  by	
  liver	
  X	
  receptors.	
  J	
  Biol	
  Chem	
  277,	
  
          11019-­-11025.	
  

     187. Chisholm,	
   J.W.,	
   Hong,	
   J.,	
   Mills,	
   S.A.,	
   Lawn,	
   R.M.,	
   2003.	
   The	
   LXR	
   ligand	
   T0901317	
  
          induces	
  severe	
  lipogenesis	
  in	
  the	
  db/db	
  diabetic	
  mouse.	
  J	
  Lipid	
  Res	
  44,	
  2039-­-2048.	
  

     188. 	
  Grefhorst,	
  A.,	
  Elzinga,	
  B.M.,	
  Voshol,	
  P.J.	
  y	
  col.	
  2002.	
  Stimulation	
  of	
  lipogenesis	
  by	
  
          pharmacological	
   activation	
   of	
   the	
   liver	
   X	
   receptor	
   leads	
   to	
   production	
   of	
   large,	
  
          triglyceride-­-rich	
  very	
  low	
  density	
  lipoprotein	
  particles.	
  J	
  Biol	
  Chem	
  277,	
  34182-­-34190.	
  

     189. Ducheix,	
   S.,	
   Montagner,	
   A.,	
   Polizzi,	
   A.	
   y	
   col.	
   2013.	
   Essential	
   fatty	
   acids	
   deficiency	
  
          promotes	
   lipogenic	
   gene	
   expression	
   and	
   hepatic	
   steatosis	
   through	
   the	
   liver	
   X	
   receptor.	
   J	
  
          Hepatol	
  58,	
  984-­-992.	
  

     190. Patel,	
  R.,	
  Patel,	
  M.,	
  Tsai,	
  R.	
  y	
  col.	
  2011.	
  LXRß	
  is	
  required	
  for	
  glucocorticoid-­-induced	
  
          hyperglycemia	
  and	
  hepatosteatosis	
  in	
  mice.	
  J	
  Clin	
  Invest	
  121,	
  431-­-441.	
  

     191. Ducheix,	
   S.,	
   Montagner,	
   A.,	
   Theodorou,	
   V.	
   y	
   col.	
   2013.	
   The	
   liver	
   X	
   receptor:	
   a	
  
          master	
   regulator	
   of	
   the	
   gut-­-liver	
   axis	
   and	
   a	
   target	
   for	
   non	
   alcoholic	
   fatty	
   liver	
   disease.	
  
          Biochem	
  Pharmacol	
  86,	
  96-­-105.	
  

     192. Higuchi,	
  N.,	
  Kato,	
  M.,	
  Shundo,	
  Y.	
  y	
  col.	
  2008.	
  Liver	
  X	
  receptor	
  in	
  cooperation	
  with	
  
          SREBP-­-1c	
   is	
   a	
   major	
   lipid	
   synthesis	
   regulator	
   in	
   nonalcoholic	
   fatty	
   liver	
   disease.	
  Hepatol	
  
          Res	
  38,	
  1122-­-1129.	
  

     193. Zelcer,	
   N.,	
   Tontonoz,	
   P.,	
   2006.	
   Liver	
   X	
   receptors	
   as	
   integrators	
   of	
   metabolic	
   and	
  
          inflammatory	
  signaling.	
  J	
  Clin	
  Invest	
  116,	
  607-­-614.	
  

     194. Hong,	
   C.,	
   Tontonoz,	
   P.,	
   2008.	
   Coordination	
   of	
   inflammation	
   and	
   metabolism	
   by	
  
          PPAR	
  and	
  LXR	
  nuclear	
  receptors.	
  Curr	
  Opin	
  Genet	
  Dev	
  18,	
  461-­-467.	
  

     195. Jakobsson,	
   T.,	
   Treuter,	
   E.,	
   Gustafsson,	
   J.,	
   Steffensen,	
   K.R.,	
   2012.	
   Liver	
   X	
   receptor	
  
          biology	
   and	
   pharmacology:	
   new	
   pathways,	
   challenges	
   and	
   opportunities.	
   Trends	
  
          Pharmacol	
  Sci	
  33,	
  394-­-404.	
  

     196. Wang,	
   Y.Y.,	
   Dahle,	
   M.K.,	
   Agren,	
   J.	
   y	
   col.	
   2006.	
   Activation	
   of	
   the	
   liver	
   X	
   receptor	
  
          protects	
   against	
   hepatic	
   injury	
   in	
   endotoxemia	
   by	
   suppressing	
   Kupffer	
   cell	
   activation.	
  
          Shock	
  25,	
  141-­-146.	
  

     197. Mallat,	
   A.,	
   Lotersztajn,	
   S.,	
   2011.	
   The	
   liver	
   X	
   receptor	
   in	
   hepatic	
   stellate	
   cells:	
   a	
  
          novel	
  antifibrogenic	
  target?	
  J	
  Hepatol	
  55,	
  1452-­-1454.	
  

     198. Beaven,	
  S.W.,	
  Wroblewski,	
  K.,	
  Wang,	
  J.	
  y	
  col.	
  2011.	
  Liver	
  X	
  receptor	
  signaling	
  is	
  a	
  
          determinant	
   of	
   stellate	
   cell	
   activation	
   and	
   susceptibility	
   to	
   fibrotic	
   liver	
   disease.	
  
          Gastroenterology	
  140,	
  1052-­-1062.	
  

                                                                                                                               	
  47	
  

	
  
   43   44   45   46   47   48   49   50   51   52   53