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SREBP-­-1c,	
  ChREBP	
  y	
  LXR…	
  

	
  

     135. Cha,	
  J.Y.,	
  Repa,	
  J.J.,	
  2007.	
  The	
   liver	
   X	
   receptor	
   (LXR)	
   and	
   hepatic	
   lipogenesis.	
   The	
  
          carbohydrate-­-response	
   element-­-binding	
   protein	
   is	
   a	
   target	
   gene	
   of	
   LXR.	
   J	
   Biol	
   Chem	
   282,	
  
          743-­-751.	
  

     136. Gauthier,	
   K.,	
   Billon,	
   C.,	
   Bissler,	
   M.	
   y	
   col.	
   2010.	
   Thyroid	
   hormone	
   receptor	
   beta	
  
          (TRbeta)	
   and	
   liver	
   X	
   receptor	
   (LXR)	
   regulate	
   carbohydrate-­-response	
   element-­-binding	
  
          protein	
  (ChREBP)	
  expression	
  in	
  a	
  tissue-­-selective	
  manner.	
  J	
  Biol	
  Chem	
  285,	
  28156-­-28163.	
  

     137. Iizuka,	
  K.,	
  Bruick,	
  R.K.,	
  Liang,	
  G.	
  y	
  col.	
  2004.	
  Deficiency	
  of	
  carbohydrate	
  response	
  
          element-­-binding	
   protein	
   (ChREBP)	
   reduces	
   lipogenesis	
   as	
   well	
   as	
   glycolysis.	
   Proc	
   Natl	
  
          Acad	
  Sci	
  U	
  S	
  A	
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  7281-­-7286.	
  

     138. Repa,	
   J.J.,	
   Liang,	
   G.,	
   Ou,	
   J.	
   y	
   col.	
   2000.	
   Regulation	
   of	
   mouse	
   sterol	
   regulatory	
  
          element-­-binding	
   protein-­-1c	
   gene	
   (SREBP-­-1c)	
   by	
   oxysterol	
   receptors,	
   LXRalpha	
   and	
  
          LXRbeta.	
  Genes	
  Dev	
  14,	
  2819-­-2830.	
  

     139. Sirek,	
   A.S.,	
   Liu,	
   L.,	
   Naples,	
   M.	
   y	
   col.	
   2009.	
   Insulin	
   stimulates	
   the	
   expression	
   of	
  
          carbohydrate	
   response	
   element	
   binding	
   protein	
   (ChREBP)	
   by	
   attenuating	
   the	
   repressive	
  
          effect	
   of	
   Pit-­-1,	
   Oct-­-1/Oct-­-2,	
   and	
   Unc-­-86	
   homeodomain	
   protein	
   octamer	
   transcription	
  
          factor-­-1.	
  Endocrinology	
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  3483-­-3492.	
  

     140. Havula,	
   E.,	
   Hietakangas,	
   V.,	
   2012.	
   Glucose	
   sensing	
   by	
   ChREBP/MondoA-­-Mlx	
  
          transcription	
  factors.	
  Semin	
  Cell	
  Dev	
  Biol	
  23,	
  640-­-647.	
  

     141. Hurtado	
   del	
   Pozo,	
   C.,	
   Vesperinas-­-García,	
   G.,	
   Rubio,	
   M.	
   y	
   col.	
   2011.	
   ChREBP	
  
          expression	
  in	
  the	
  liver,	
  adipose	
  tissue	
  and	
  differentiated	
  preadipocytes	
  in	
  human	
  obesity.	
  
          Biochim	
  Biophys	
  Acta	
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  1194-­-1200.	
  

     142. Benhamed,	
   F.,	
   Denechaud,	
   P.D.,	
   Lemoine,	
   M.	
   y	
   col.	
   2012.	
   The	
   lipogenic	
  
          transcription	
   factor	
   ChREBP	
   dissociates	
   hepatic	
   steatosis	
   from	
   insulin	
   resistance	
   in	
   mice	
  
          and	
  humans.	
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  Clin	
  Invest	
  122,	
  2176-­-2194.	
  

     143. Dentin,	
   R.,	
   Benhamed,	
   F.,	
   Hainault,	
   I.	
   y	
   col.2006.	
   Liver-­-specific	
   inhibition	
   of	
  
          ChREBP	
   improves	
   hepatic	
   steatosis	
   and	
   insulin	
   resistance	
   in	
   ob/ob	
   mice.	
   Diabetes	
   55,	
  
          2159-­-2170.	
  

     144. Iizuka,	
   K.,	
   Takeda,	
   J.,	
   Horikawa,	
   Y.,	
   2009.	
   Hepatic	
   overexpression	
   of	
   dominant	
  
          negative	
   Mlx	
   improves	
   metabolic	
   profile	
   in	
   diabetes-­-prone	
   C57BL/6J	
   mice.	
   Biochem	
  
          Biophys	
  Res	
  Commun	
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  499-­-504.	
  

     145. Robichon,	
  C.,	
  Girard,	
  J.,	
  Postic,	
  C.,	
  2008.	
  [Can	
  the	
  hyperactivity	
  of	
  lipogenesis	
  cause	
  
          hepatic	
  steatosis?	
  A	
  role	
  for	
  ChREBP].	
  Med	
  Sci	
  (Paris)	
  24,	
  841-­-846.	
  

     146. Lodhi,	
   I.J.,	
   Wei,	
   X.,	
   Semenkovich,	
   C.F.,	
   2011.	
   Lipoexpediency:	
   de	
   novo	
   lipogenesis	
  
          as	
  a	
  metabolic	
  signal	
  transmitter.	
  Trends	
  Endocrinol	
  Metab	
  22,	
  1-­-8.	
  

     147. Charlton,	
  M.R.,	
  2013.	
  ChREBP	
  in	
  NASH	
  -­-	
  a	
  liver	
  transcription	
  factor	
  comes	
  in	
  from	
  
          the	
  cold.	
  J	
  Hepatol	
  59,	
  178-­-179.	
  

     148. Färnegårdh,	
   M.,	
   Bonn,	
   T.,	
   Sun,	
   S.	
   y	
   col.	
   2003.	
   The	
   three-­-dimensional	
   structure	
   of	
  
          the	
   liver	
   X	
   receptor	
   beta	
   reveals	
   a	
   flexible	
   ligand-­-binding	
   pocket	
   that	
   can	
   accommodate	
  
          fundamentally	
  different	
  ligands.	
  J	
  Biol	
  Chem	
  278,	
  38821-­-38828.	
  

     149. Peet,	
  D.J.,	
  Turley,	
  S.D.,	
  Ma,	
  W.	
  y	
  col.	
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  Cholesterol	
  and	
  bile	
  acid	
  metabolism	
  are	
  
          impaired	
  in	
  mice	
  lacking	
  the	
  nuclear	
  oxysterol	
  receptor	
  LXR	
  alpha.	
  Cell	
  93,	
  693-­-704.	
  

     150. Blaschke,	
   F.,	
   Takata,	
   Y.,	
   Caglayan,	
   E.	
   y	
   col.	
   2006.	
   A	
   nuclear	
   receptor	
   corepressor-­-
          dependent	
   pathway	
   mediates	
   suppression	
   of	
   cytokine-­-induced	
   C-­-reactive	
   protein	
   gene	
  
          expression	
  by	
  liver	
  X	
  receptor.	
  Circ	
  Res	
  99,	
  e88-­-99.	
  

     151. Willy,	
  P.J.,	
  Umesono,	
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  Ong,	
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  y	
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  LXR,	
  a	
  nuclear	
  receptor	
  that	
  defines	
  a	
  
          distinct	
  retinoid	
  response	
  pathway.	
  Genes	
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     152. Zhang,	
  Y.,	
  Repa,	
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  Mangelsdorf,	
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  Regulation	
  of	
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          lipase	
  by	
  the	
  oxysterol	
  receptors,	
  LXRalpha	
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  J	
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  Chem	
  276,	
  43018-­-43024.	
  

     153. Korach-­-André,	
   M.,	
   Parini,	
   P.,	
   Larsson,	
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   y	
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   Separate	
   and	
   overlapping	
  
          metabolic	
   functions	
   of	
   LXRalpha	
   and	
   LXRbeta	
   in	
   C57Bl/6	
   female	
   mice.	
   Am	
   J	
   Physiol	
  
          Endocrinol	
  Metab	
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  E167-­-178.	
  

     154. Korach-­-André,	
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  Archer,	
  A.,	
  Barros,	
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  y	
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  Both	
  liver-­-X	
  receptor	
  (LXR)	
  
          isoforms	
  control	
  energy	
  expenditure	
  by	
  regulating	
  brown	
  adipose	
  tissue	
  activity.	
  Proc	
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          Acad	
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  U	
  S	
  A	
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     155. Viennois,	
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   Pommier,	
   A.J.,	
   Mouzat,	
   K.	
   y	
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   2011.	
   Targeting	
   liver	
   X	
   receptors	
   in	
  
          human	
  health:	
  deadlock	
  or	
  promising	
  trail?	
  Expert	
  Opin	
  Ther	
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     156. Chen,	
   J.D.,	
   Evans,	
   R.M.,	
   1995.	
   A	
   transcriptional	
   co-­-repressor	
   that	
   interacts	
   with	
  
          nuclear	
  hormone	
  receptors.	
  Nature	
  377,	
  454-­-457.	
  

                                                                                                                               	
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