Page 46 - 80_01
P. 46
SREBP--1c,
ChREBP
y
LXR…
135. Cha,
J.Y.,
Repa,
J.J.,
2007.
The
liver
X
receptor
(LXR)
and
hepatic
lipogenesis.
The
carbohydrate--response
element--binding
protein
is
a
target
gene
of
LXR.
J
Biol
Chem
282,
743--751.
136. Gauthier,
K.,
Billon,
C.,
Bissler,
M.
y
col.
2010.
Thyroid
hormone
receptor
beta
(TRbeta)
and
liver
X
receptor
(LXR)
regulate
carbohydrate--response
element--binding
protein
(ChREBP)
expression
in
a
tissue--selective
manner.
J
Biol
Chem
285,
28156--28163.
137. Iizuka,
K.,
Bruick,
R.K.,
Liang,
G.
y
col.
2004.
Deficiency
of
carbohydrate
response
element--binding
protein
(ChREBP)
reduces
lipogenesis
as
well
as
glycolysis.
Proc
Natl
Acad
Sci
U
S
A
101,
7281--7286.
138. Repa,
J.J.,
Liang,
G.,
Ou,
J.
y
col.
2000.
Regulation
of
mouse
sterol
regulatory
element--binding
protein--1c
gene
(SREBP--1c)
by
oxysterol
receptors,
LXRalpha
and
LXRbeta.
Genes
Dev
14,
2819--2830.
139. Sirek,
A.S.,
Liu,
L.,
Naples,
M.
y
col.
2009.
Insulin
stimulates
the
expression
of
carbohydrate
response
element
binding
protein
(ChREBP)
by
attenuating
the
repressive
effect
of
Pit--1,
Oct--1/Oct--2,
and
Unc--86
homeodomain
protein
octamer
transcription
factor--1.
Endocrinology
150,
3483--3492.
140. Havula,
E.,
Hietakangas,
V.,
2012.
Glucose
sensing
by
ChREBP/MondoA--Mlx
transcription
factors.
Semin
Cell
Dev
Biol
23,
640--647.
141. Hurtado
del
Pozo,
C.,
Vesperinas--García,
G.,
Rubio,
M.
y
col.
2011.
ChREBP
expression
in
the
liver,
adipose
tissue
and
differentiated
preadipocytes
in
human
obesity.
Biochim
Biophys
Acta
1811,
1194--1200.
142. Benhamed,
F.,
Denechaud,
P.D.,
Lemoine,
M.
y
col.
2012.
The
lipogenic
transcription
factor
ChREBP
dissociates
hepatic
steatosis
from
insulin
resistance
in
mice
and
humans.
J
Clin
Invest
122,
2176--2194.
143. Dentin,
R.,
Benhamed,
F.,
Hainault,
I.
y
col.2006.
Liver--specific
inhibition
of
ChREBP
improves
hepatic
steatosis
and
insulin
resistance
in
ob/ob
mice.
Diabetes
55,
2159--2170.
144. Iizuka,
K.,
Takeda,
J.,
Horikawa,
Y.,
2009.
Hepatic
overexpression
of
dominant
negative
Mlx
improves
metabolic
profile
in
diabetes--prone
C57BL/6J
mice.
Biochem
Biophys
Res
Commun
379,
499--504.
145. Robichon,
C.,
Girard,
J.,
Postic,
C.,
2008.
[Can
the
hyperactivity
of
lipogenesis
cause
hepatic
steatosis?
A
role
for
ChREBP].
Med
Sci
(Paris)
24,
841--846.
146. Lodhi,
I.J.,
Wei,
X.,
Semenkovich,
C.F.,
2011.
Lipoexpediency:
de
novo
lipogenesis
as
a
metabolic
signal
transmitter.
Trends
Endocrinol
Metab
22,
1--8.
147. Charlton,
M.R.,
2013.
ChREBP
in
NASH
--
a
liver
transcription
factor
comes
in
from
the
cold.
J
Hepatol
59,
178--179.
148. Färnegårdh,
M.,
Bonn,
T.,
Sun,
S.
y
col.
2003.
The
three--dimensional
structure
of
the
liver
X
receptor
beta
reveals
a
flexible
ligand--binding
pocket
that
can
accommodate
fundamentally
different
ligands.
J
Biol
Chem
278,
38821--38828.
149. Peet,
D.J.,
Turley,
S.D.,
Ma,
W.
y
col.
1998.
Cholesterol
and
bile
acid
metabolism
are
impaired
in
mice
lacking
the
nuclear
oxysterol
receptor
LXR
alpha.
Cell
93,
693--704.
150. Blaschke,
F.,
Takata,
Y.,
Caglayan,
E.
y
col.
2006.
A
nuclear
receptor
corepressor--
dependent
pathway
mediates
suppression
of
cytokine--induced
C--reactive
protein
gene
expression
by
liver
X
receptor.
Circ
Res
99,
e88--99.
151. Willy,
P.J.,
Umesono,
K.,
Ong,
E.S.
y
col.
1995.
LXR,
a
nuclear
receptor
that
defines
a
distinct
retinoid
response
pathway.
Genes
Dev
9,
1033--1045
152. Zhang,
Y.,
Repa,
J.J.,
Gauthier,
K.,
Mangelsdorf,
D.J.,
2001.
Regulation
of
lipoprotein
lipase
by
the
oxysterol
receptors,
LXRalpha
and
LXRbeta.
J
Biol
Chem
276,
43018--43024.
153. Korach--André,
M.,
Parini,
P.,
Larsson,
L.
y
col.
2010.
Separate
and
overlapping
metabolic
functions
of
LXRalpha
and
LXRbeta
in
C57Bl/6
female
mice.
Am
J
Physiol
Endocrinol
Metab
298,
E167--178.
154. Korach--André,
M.,
Archer,
A.,
Barros,
R.P.
y
col.
2011.
Both
liver--X
receptor
(LXR)
isoforms
control
energy
expenditure
by
regulating
brown
adipose
tissue
activity.
Proc
Natl
Acad
Sci
U
S
A
108,
403--408.
155. Viennois,
E.,
Pommier,
A.J.,
Mouzat,
K.
y
col.
2011.
Targeting
liver
X
receptors
in
human
health:
deadlock
or
promising
trail?
Expert
Opin
Ther
Targets
15,
219--232.
156. Chen,
J.D.,
Evans,
R.M.,
1995.
A
transcriptional
co--repressor
that
interacts
with
nuclear
hormone
receptors.
Nature
377,
454--457.
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