Page 47 - 80_01
P. 47

Elvira	
  López-­-Oliva	
  Muñoz,	
  Emilia	
  Muñoz	
  Martínez	
  

	
  

     157. Glass,	
   C.K.,	
   Rosenfeld,	
   M.G.,	
   2000.	
   The	
   coregulator	
   exchange	
   in	
   transcriptional	
  
          functions	
  of	
  nuclear	
  receptors.	
  Genes	
  Dev	
  14,	
  121-­-141.	
  

     158. 	
  Lee,	
   S.,	
   Lee,	
   J.,	
   Lee,	
   S.K.,	
   Lee,	
   J.W.,	
   2008.	
   Activating	
   signal	
   cointegrator-­-2	
   is	
   an	
  
          essential	
  adaptor	
  to	
  recruit	
  histone	
  H3	
  lysine	
  4	
  methyltransferases	
  MLL3	
  and	
  MLL4	
  to	
  the	
  
          liver	
  X	
  receptors.	
  Mol	
  Endocrinol	
  22,	
  1312-­-1319.	
  

     159. Jakobsson,	
   T.,	
   Venteclef,	
   N.,	
   Toresson,	
   G.	
   y	
   col.	
   2009.	
   GPS2	
   is	
   required	
   for	
  
          cholesterol	
   efflux	
   by	
   triggering	
   histone	
   demethylation,	
   LXR	
   recruitment,	
   and	
   coregulator	
  
          assembly	
  at	
  the	
  ABCG1	
  locus.	
  Mol	
  Cell	
  34,	
  510-­-518.	
  

     160. Venteclef,	
   N.,	
   Jakobsson,	
   T.,	
   Ehrlund,	
   A.	
   y	
   col.	
   2010.	
   GPS2-­-dependent	
  
          corepressor/SUMO	
   pathways	
   govern	
   anti-­-inflammatory	
   actions	
   of	
   LRH-­-1	
   and	
   LXRbeta	
   in	
  
          the	
  hepatic	
  acute	
  phase	
  response.	
  Genes	
  Dev	
  24,	
  381-­-395.	
  

     161. Lehmann,	
   J.M.,	
   Kliewer,	
   S.A.,	
   Moore,	
   L.B.	
   y	
   col.	
   1997.	
   Activation	
   of	
   the	
   nuclear	
  
          receptor	
   LXR	
   by	
   oxysterols	
   defines	
   a	
   new	
   hormone	
   response	
   pathway.	
   J	
   Biol	
   Chem	
   272,	
  
          3137-­-3140.	
  

     162. Li,	
  X.,	
  Yeh,	
  V.,	
  Molteni,	
  V.,	
  2010.	
  Liver	
  X	
  receptor	
  modulators:	
  a	
  review	
  of	
  recently	
  
          patented	
  compounds	
  (2007-­-	
  2009).	
  Expert	
  Opin	
  Ther	
  Pat	
  20,	
  535-­-562.	
  

     163. Ou,	
  J.,	
  Tu,	
  H.,	
  Shan,	
  B.	
  y	
  col.	
  2001.	
  Unsaturated	
  fatty	
  acids	
  inhibit	
  transcription	
  of	
  
          the	
  sterol	
  regulatory	
  element-­-binding	
  protein-­-1c	
  (SREBP-­-1c)	
  gene	
  by	
  antagonizing	
  ligand-­-
          dependent	
  activation	
  of	
  the	
  LXR.	
  Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  98,	
  6027-­-6032.	
  

     164. Oberkofler,	
   H.,	
   Schraml,	
   E.,	
   Krempler,	
   F.,	
   Patsch,	
   W.,	
   2003.	
  Potentiation	
   of	
   liver	
   X	
  
          receptor	
  transcriptional	
  activity	
  by	
  peroxisome-­-proliferator-­-activated	
  receptor	
  gamma	
  co-­-
          activator	
  1	
  alpha.	
  Biochem	
  J	
  371,	
  89-­-96.	
  

     165. Li,	
  X.,	
  Zhang,	
  S.,	
  Blander,	
  G.	
  y	
  col.	
  2007.	
  SIRT1	
  deacetylates	
  and	
  positively	
  regulates	
  
          the	
  nuclear	
  receptor	
  LXR.	
  Mol	
  Cell	
  28,	
  91-­-106.	
  

     166. Yamamoto,	
   T.,	
   Shimano,	
   H.,	
   Inoue,	
   N.	
   y	
   col.2007.	
   Protein	
   kinase	
   A	
   suppresses	
  
          sterol	
   regulatory	
   element-­-binding	
   protein-­-1C	
   expression	
   via	
   phosphorylation	
   of	
   liver	
   X	
  
          receptor	
  in	
  the	
  liver.	
  J	
  Biol	
  Chem	
  282,	
  11687-­-11695.	
  

     167. Tobin,	
   K.A.,	
   Ulven,	
   S.M.,	
   Schuster,	
   G.U.	
   y	
   col.	
   2002.	
   Liver	
   X	
   receptors	
   as	
   insulin-­-
          mediating	
   factors	
   in	
   fatty	
   acid	
   and	
   cholesterol	
   biosynthesis.	
   J	
   Biol	
   Chem	
   277,	
   10691-­-
          10697.	
  

     168. Liu,	
  X.,	
  Qiao,	
  A.,	
  Ke,	
  Y.	
  y	
  col.	
  2010.	
  FoxO1	
  represses	
  LXRa-­-mediated	
  transcriptional	
  
          activity	
  of	
  SREBP-­-1c	
  promoter	
  in	
  HepG2	
  cells.	
  FEBS	
  Lett	
  584,	
  4330-­-4334.	
  

     169. Chinetti,	
   G.,	
   Lestavel,	
   S.,	
   Bocher,	
   V.	
   y	
   col.	
   2001.	
   PPAR-­-alpha	
   and	
   PPAR-­-gamma	
  
          activators	
   induce	
   cholesterol	
   removal	
   from	
   human	
   macrophage	
   foam	
   cells	
   through	
  
          stimulation	
  of	
  the	
  ABCA1	
  pathway.	
  Nat	
  Med	
  7,	
  53-­-58.	
  

     170. Brendel,	
   C.,	
   Schoonjans,	
   K.,	
   Botrugno,	
   O.A.	
   y	
   col.	
   2002.	
   The	
   small	
   heterodimer	
  
          partner	
  interacts	
  with	
  the	
  liver	
  X	
  receptor	
  alpha	
  and	
  represses	
  its	
  transcriptional	
  activity.	
  
          Mol	
  Endocrinol	
  16,	
  2065-­-2076.	
  

     171. Kalaany,	
   N.Y.,	
   Gauthier,	
   K.C.,	
   Zavacki,	
   A.M.	
   y	
   col.	
   2005.	
   LXRs	
   regulate	
   the	
   balance	
  
          between	
  fat	
  storage	
  and	
  oxidation.	
  Cell	
  Metab	
  1,	
  231-­-244.	
  

     172. Repa,	
   J.J.,	
   Turley,	
   S.D.,	
   Lobaccaro,	
   J.A.	
   y	
   col.	
   2000.	
   Regulation	
   of	
   absorption	
   and	
  
          ABC1-­-mediated	
  efflux	
  of	
  cholesterol	
  by	
  RXR	
  heterodimers.	
  Science	
  289,	
  1524-­-1529.	
  

     173. Brunham,	
   L.R.,	
   Kruit,	
   J.K.,	
   Pape,	
   T.D.	
   y	
   col.	
   2006.	
   Tissue-­-specific	
   induction	
   of	
  
          intestinal	
  ABCA1	
  expression	
  with	
  a	
  liver	
  X	
  receptor	
  agonist	
  raises	
  plasma	
  HDL	
  cholesterol	
  
          levels.	
  Circ	
  Res	
  99,	
  672-­-674.	
  

     174. Feig,	
   J.E.,	
   Pineda-­-Torra,	
   I.,	
   Sanson,	
   M.	
   y	
   col.	
   2010.	
   LXR	
   promotes	
   the	
   maximal	
  
          egress	
   of	
   monocyte-­-derived	
   cells	
   from	
   mouse	
   aortic	
   plaques	
   during	
   atherosclerosis	
  
          regression.	
  J	
  Clin	
  Invest	
  120,	
  4415-­-4424.	
  

     175. Cao,	
   G.,	
   Liang,	
   Y.,	
   Broderick,	
   C.L.	
   y	
   col.	
   2003.	
   Antidiabetic	
   action	
   of	
   a	
   liver	
   x	
  
          receptor	
   agonist	
   mediated	
   by	
   inhibition	
   of	
   hepatic	
   gluconeogenesis.	
   J	
   Biol	
   Chem	
   278,	
  
          1131-­-1136.	
  

     176. Grefhorst,	
   A.,	
   van	
   Dijk,	
   T.H.,	
   Hammer,	
   A.	
   y	
   col.	
   2005.	
   Differential	
   effects	
   of	
  
          pharmacological	
  liver	
  X	
  receptor	
  activation	
  on	
  hepatic	
  and	
  peripheral	
  insulin	
  sensitivity	
  in	
  
          lean	
  and	
  ob/ob	
  mice.	
  Am	
  J	
  Physiol	
  Endocrinol	
  Metab	
  289,	
  E829-­-838.	
  

     177. Laffitte,	
   B.A.,	
   Chao,	
   L.C.,	
   Li,	
   J.	
   y	
   col.	
   2003.	
   Activation	
   of	
   liver	
   X	
   receptor	
   improves	
  
          glucose	
   tolerance	
   through	
   coordinate	
   regulation	
   of	
   glucose	
   metabolism	
   in	
   liver	
   and	
  
          adipose	
  tissue.	
  Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  100,	
  5419-­-5424.	
  

46	
  

	
  
   42   43   44   45   46   47   48   49   50   51   52