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Elvira	
  López-­-Oliva	
  Muñoz,	
  Emilia	
  Muñoz	
  Martínez	
  

	
  

     114. Yecies,	
  J.L.,	
  Zhang,	
  H.H.,	
  Menon,	
  S.	
  y	
  col.	
  2011.	
  Akt	
  stimulates	
  hepatic	
  SREBP1c	
  and	
  
          lipogenesis	
   through	
   parallel	
   mTORC1-­-dependent	
   and	
   independent	
   pathways.	
   Cell	
   Metab	
  
          14,	
  21-­-32.	
  

     115. Moon,	
  Y.A.,	
  Liang,	
  G.,	
  Xie,	
  X.	
  y	
  col.	
  2012.	
  The	
  Scap/SREBP	
  pathway	
  is	
  essential	
  for	
  
          developing	
  diabetic	
  fatty	
  liver	
  and	
  carbohydrate-­-induced	
  hypertriglyceridemia	
  in	
  animals.	
  
          Cell	
  Metab	
  15,	
  240-­-246.	
  

     116. Tang,	
   J.J.,	
   Li,	
   J.G.,	
   Qi,	
   W.	
   y	
   col.	
   2011.	
   Inhibition	
   of	
   SREBP	
   by	
   a	
   small	
   molecule,	
  
          betulin,	
   improves	
   hyperlipidemia	
   and	
   insulin	
   resistance	
   and	
   reduces	
   atherosclerotic	
  
          plaques.	
  Cell	
  Metab	
  13,	
  44-­-56.	
  

     117. Xiao,	
  X.,	
  Song,	
  B.L.,	
  2013.	
  SREBP:	
  a	
  novel	
  therapeutic	
  target.	
  Acta	
  Biochim	
  Biophys	
  
          Sin	
  (Shanghai)	
  45,	
  2-­-10.	
  

     118. Yamashita,	
  H.,	
  Takenoshita,	
  M.,	
  Sakurai,	
  M.,	
  Bruick,	
  R.K.,	
  Henzel,	
  W.J.,	
  Shillinglaw,	
  
          W.,	
   Arnot,	
   D.,	
   Uyeda,	
   K.,	
   2001.	
   A	
   glucose-­-responsive	
   transcription	
   factor	
   that	
   regulates	
  
          carbohydrate	
  metabolism	
  in	
  the	
  liver.	
  Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  98,	
  9116-­-9121.	
  

     119. Foufelle,	
  F.,	
  Gouhot,	
  B.,	
  Pégorier,	
  J.P.	
  y	
  col.	
  1992.	
  Glucose	
  stimulation	
  of	
  lipogenic	
  
          enzyme	
  gene	
  expression	
  in	
  cultured	
  white	
  adipose	
  tissue.	
  A	
  role	
  for	
  glucose	
  6-­-phosphate.	
  J	
  
          Biol	
  Chem	
  267,	
  20543-­-20546.	
  

     120. Girard,	
   J.,	
   Ferré,	
   P.,	
   Foufelle,	
   F.,	
   1997.	
   Mechanisms	
   by	
   which	
   carbohydrates	
  
          regulate	
  expression	
  of	
  genes	
  for	
  glycolytic	
  and	
  lipogenic	
  enzymes.	
  Annu	
  Rev	
  Nutr	
  17,	
  325-­-
          352.	
  

     121. Ishii,	
   S.,	
   Iizuka,	
   K.,	
   Miller,	
   B.C.,	
   Uyeda,	
   K.,	
   2004.	
   Carbohydrate	
   response	
   element	
  
          binding	
  protein	
  directly	
  promotes	
  lipogenic	
  enzyme	
  gene	
  transcription.	
  Proc	
  Natl	
  Acad	
  Sci	
  
          U	
  S	
  A	
  101,	
  15597-­-15602.	
  

     122. Iizuka,	
   K.,	
   2013.	
   Recent	
   progress	
   on	
   the	
   role	
   of	
   ChREBP	
   in	
   glucose	
   and	
   lipid	
  
          metabolism.	
  Endocr	
  J	
  60,	
  543-­-555.43.	
  	
  

     123. Herman,	
   M.A.,	
   Peroni,	
   O.D.,	
   Villoria,	
   J.	
   y	
   col.	
   2012.	
   A	
   novel	
   ChREBP	
   isoform	
   in	
  
          adipose	
  tissue	
  regulates	
  systemic	
  glucose	
  metabolism.	
  Nature	
  484,	
  333-­-338.	
  

     124. Cairo,	
  F.,	
  Rotundo,	
  R.,	
  Frazzingaro,	
  G.	
  y	
  col.	
  2001.	
  [Diabetes	
  mellitus	
  as	
  a	
  risk	
  factor	
  
          for	
  periodontitis].	
  Minerva	
  Stomatol	
  50,	
  321-­-330.	
  

     125. Kawaguchi,	
   T.,	
   Osatomi,	
   K.,	
   Yamashita,	
   H.	
   y	
   col.	
   2002.	
   Mechanism	
   for	
   fatty	
   acid	
  
          "sparing"	
   effect	
   on	
   glucose-­-induced	
   transcription:	
   regulation	
   of	
   carbohydrate-­-responsive	
  
          element-­-binding	
  protein	
  by	
  AMP-­-activated	
  protein	
  kinase.	
  J	
  Biol	
  Chem	
  277,	
  3829-­-3835.	
  

     126. Ma,	
  L.,	
  Robinson,	
  L.N.,	
  Towle,	
  H.C.,	
  2006.	
  ChREBP*Mlx	
  is	
  the	
  principal	
  mediator	
  of	
  
          glucose-­-induced	
  gene	
  expression	
  in	
  the	
  liver.	
  J	
  Biol	
  Chem	
  281,	
  28721-­-28730.55.	
  	
  

     127. Kawaguchi,	
  T.,	
  Takenoshita,	
  M.,	
  Kabashima,	
  T.,	
  Uyeda,	
  K.,	
  2001.	
  Glucose	
  and	
  cAMP	
  
          regulate	
   the	
   L-­-type	
   pyruvate	
   kinase	
   gene	
   by	
   phosphorylation/dephosphorylation	
   of	
   the	
  
          carbohydrate	
   response	
   element	
   binding	
   protein.	
   Proc	
   Natl	
   Acad	
   Sci	
   U	
   S	
   A	
   98,	
   13710-­-
          13715.	
  

     128. Tsatsos,	
   N.G.,	
   Towle,	
   H.C.,	
   2006.	
   Glucose	
   activation	
   of	
   ChREBP	
   in	
   hepatocytes	
  
          occurs	
  via	
  a	
  two-­-step	
  mechanism.	
  Biochem	
  Biophys	
  Res	
  Commun	
  340,	
  449-­-456.	
  

     129. Bricambert,	
  J.,	
  Miranda,	
  J.,	
  Benhamed,	
  F.	
  y	
  col.	
  2010.	
  Salt-­-inducible	
  kinase	
  2	
  links	
  
          transcriptional	
  coactivator	
  p300	
  phosphorylation	
  to	
  the	
  prevention	
  of	
  ChREBP-­-dependent	
  
          hepatic	
  steatosis	
  in	
  mice.	
  J	
  Clin	
  Invest	
  120,	
  4316-­-4331.	
  

     130. Zeidan,	
   Q.,	
   Hart,	
   G.W.,	
   2010.	
   The	
   intersections	
   between	
   O-­-GlcNAcylation	
   and	
  
          phosphorylation:	
  implications	
  for	
  multiple	
  signaling	
  pathways.	
  J	
  Cell	
  Sci	
  123,	
  13-­-22.	
  

     131. Guinez,	
   C.,	
   Filhoulaud,	
   G.,	
   Rayah-­-Benhamed,	
   F.	
   y	
   col.	
   2011.	
   O-­-GlcNAcylation	
  
          increases	
   ChREBP	
   protein	
   content	
   and	
   transcriptional	
   activity	
   in	
   the	
   liver.	
   Diabetes	
   60,	
  
          1399-­-1413.	
  

     132. Kabashima,	
   T.,	
   Kawaguchi,	
   T.,	
   Wadzinski,	
   B.E.,	
   Uyeda,	
   K.,	
   2003.	
   Xylulose	
   5-­-
          phosphate	
   mediates	
   glucose-­-induced	
   lipogenesis	
   by	
   xylulose	
   5-­-phosphate-­-activated	
  
          protein	
  phosphatase	
  in	
  rat	
  liver.	
  Proc	
  Natl	
  Acad	
  Sci	
  U	
  S	
  A	
  100,	
  5107-­-5112.57.	
  

     133. Dentin,	
   R.,	
   Tomas-­-Cobos,	
   L.,	
   Foufelle,	
   F.	
   y	
   col.	
   2012.	
   Glucose	
   6-­-phosphate,	
   rather	
  
          than	
  xylulose	
  5-­-phosphate,	
  is	
  required	
  for	
  the	
  activation	
  of	
  ChREBP	
  in	
  response	
  to	
  glucose	
  
          in	
  the	
  liver.	
  J	
  Hepatol	
  56,	
  199-­-209.	
  

     134. Arden,	
   C.,	
   Tudhope,	
   S.J.,	
   Petrie,	
   J.L.	
   y	
   col.	
   2012.	
   Fructose	
   2,6-­-bisphosphate	
   is	
  
          essential	
   for	
   glucose-­-regulated	
   gene	
   transcription	
   of	
   glucose-­-6-­-phosphatase	
   and	
   other	
  
          ChREBP	
  target	
  genes	
  in	
  hepatocytes.	
  Biochem	
  J	
  443,	
  111-­-123.	
  

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