Page 59 - 76_01
P. 59
VOL. 76 (1), 105-118, 2010 EL YING Y EL YANG DE LOS TELÓMEROS...
9. Blasco, M. A.; Funk, W.; Villaponteau, B. & Greider, C. W. (1995) Functional
characterization and developmental regulation of mouse telomerase RNA
component. Science. 269: 1267-1270.
10. Blasco, M. A.; Lee, H.-W.; Hande, P.; Samper, E.; Lansdorp, P.; DePinho, R.
A. & Greider, C. W.(1997) Telomere shortening and tumor formation by mouse
cells lacking telomerase RNA. Cell. 91: 25-34.
11. Lee, H.-W.; Blasco, M. A.; Gottlieb, G. J.; Greider, C. W. & DePinho, R. A.
(1998) Essential role of mouse telomerase in highly proliferative organs. Na-
ture. 392: 569-574.
12. Herrera, E.; Samper, E. & Blasco, M. A. (1999) Telomere shortening in mTR–/–
embryos is associated with a failure to close the neural tube. EMBO J. 18: 1172-
1181.
13. González-Suárez, E.; Samper, E.; Flores, J. M. & Blasco, M. A. (2000) Telome-
rase-deficient mice with short telomeres are resistant to skin tumorigenesis.
Nature Genetics. 26: 114-117.
14. Flores, I.; Cayuela, M. L. & Blasco, M. A. (2005) Effects of Telomerase and
Telomere Length on Epidermal Stem Cell Behavior. Science. 309: 1253-1256.
15. Flores, I. & Blasco, M. A. (2009) A p53-dependent response limits epidermal
stem cell functionality and organismal size in mice with short telomeres. PLoS
One. 4(3): e4934.
16. Serrano, M. & Blasco, M. A. (2007). Cancer and ageing: convergent and diver-
gent mechanisms. Nat. Rev. Mol. Cell. Biol. 8: 715-722.
17. Tomás-Loba, A.; Flores, I.; Fernández-Marcos, P.; Cayuela, M. L.; Maraver, A.;
Tejera, A.; Borras, C.; Matheu, A.; Klatt, P.; Flores, J. M.; Viña, J.; Serrano, M.
& Blasco, M. A. (2008) Telomerase reverse transcriptase delays aging in can-
cer resistant mice. Cell. 35: 609-622.
18. Campbell, K. H.; McWhir, J.; Ritchie, W. A. & Wilmut, I. (1996) Sheep cloned
by nuclear transfer from a cultured cell line. Nature. 380: 64-66.
19. Takahashi, K. & Yamanaka, S. (2006) Induction of pluripotent stem cells from
mouse embryonic and adult fibroblast cultures by defined factors. Cell. 126:
663-676.
20. Takahashi, K.; Tanabe, K.; Ohnuki, M.; Narita, M.; Ichisaka, T.; Tomoda, K.
& Yamanaka, S. (2007) Induction of pluripotent stem cells from adult human
fibroblasts by defined factors. Cell. 131: 861-872.
21. Marión, R. M.; Strati, K.; Li, H.; Tejera, A.; Schoeftner, S.; Ortega, S.; Serrano,
M. & Blasco, M. A. (2009) Telomeres acquire embryonic stem cell characte-
ristics in induced pluripotent stem cells. Cell Stem Cell. 4: 141-154.
22. Marión, R. M.; Strati, K.; Li, H.; Murga, M.; Blanco, R.; Ortega, S.; Fernández-
Capetillo, O.; Serrano, M. & Blasco, M. A. (2009) A p53-mediated DNA dama-
ge response limits reprogramming to ensure iPS cell genomic integrity. Natu-
re. 460: 1149-1153.
23. Martínez, P.; Thanasoula, M.; Muñoz, P.; Liao, C.; Tejera, A.; McNees, C.;
Flores, J. M.; Fernández-Capetillo, O.; Tarsounas, M. & Blasco, M. A. (2009)
Increased telomere fragility and fusions resulting from TRF1 deficiency lead
to degenerative pathologies and increased cancer in mice. Genes Dev. 23:
2060-2075.
117
