Page 102 - 71_04
P. 102

CARMEN AVENDAÑO  AN. R. ACAD. NAC. FARM.

(43)  DHINGRA, V.; RAO, K. V., NARASU, M. L. (2000): Current status of artemisinin
(44)  and its derivatives as antimalarial drugs. Life Sci. 66: 279.
(45)  ROBERT, A.; BENOIT-VICAL, F.; DECHY-CABARET, O., MEUNIER, B. (2001): Mecha-
(46)  nism of action of artemisinin. Pure Appl. Chem. 73: 1173.
      Debido a que en el cáncer de mama se encuentra una alta concentración de
(47)  este catión, la artemisinina se está estudiando para esta posible aplicación.
(48)  O’NEILL, P. M.; BISHOP, L. P.; SEARLE, N. L.; MAGGS, J. L.; STORR, R. C., WARD,
(49)  S. (2000): Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611).
      The first EPR spin-trapping evidence for the previously postulated secondary
(50)  carbon-centered cyclohexyl radical. J. Org. Chem. 65: 1578-82.
      ROBERT, A.; CAZELLES, J., MUNIER, B. (2001): Characterization of the Alkylation
(51)  Product of Heme by the Antimalarial Drug Artemisinin. Angew. Chem. Int.
      Ed. 40: 1954.
(52)  BASCO, L. K.; BICKII, J., RINGWALD, P. (1998): In vitro activity of lumefantrine
      (benflumetol) against clinical isolates of Plasmodium falciparum in Yaounde,
      Cameroon. Antimicrob. Agents Chemother. 42: 2347.
      MAGGS, J. L.; BISHOP, L. P. D.; EDWARDS, G.; O’NEILL, P. M.; WARD, S. A.;
      WINSTANLEY, P. A., PARK, B. K. (2000): Biliary metabolites of beta-artemether
      in rats: biotransformations of an antimalarial endoperoxide. Drug Met. Disp.
      28: 209.
      O’NEILL, P. M.; SEARLE, N. L.; KAN, K. W.; STORR, R. C.; MAGGS, J. L.; WARD,
      S. A.; RAYNES, K., PARK, B. K. (1999): Novel, potent, semisynthetic antimala-
      rial carbaanalogues of the first-generation 1,2,4-trioxane artemether. J. Med.
      Chem. 42: 5487.
      O’NEILL, P. M.; MILLER, A.; WARD, S. A.; PARK, B. K.; SCHEINMANN, F., STACHUL-
      SKI, A. V. (1999): Application of the TMSOTf-AgClO4 Activator System to the
      Synthesis of Novel, Potent, C-10 Phenoxy Derivatives of Dihydroartemisinin.
      Tetrahedron Lett. 40: 9129.
      O’NEILL, P. M.; BISHOP, L.; HAWLEY, S. R.; STORR, R. C.; WARD, S. A.; PARK, B.
      K. (1996): Mechanism-based design of parasite-targeted artemisinin deriva-
      tives: synthesis and antimalarial activity of benzylamino and alkylamino ether
      analogues of artemisinin. J. Med. Chem. 39: 4511.

904
   97   98   99   100   101   102   103   104   105   106   107