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129ANALESRANFwwwanalesranfcomAntibioticresistanceininfectionsassociatedwithhealthcareinCOVID-19pandemicJorgeAAlmeidaVillegasJoséAGutiérrezGutiérrezetalAnRealAcadFarmVol88nº2(2022)·pp123-130theincreaseinresistancetoantibioticsinthecOVID-19pandemichas setoffalarmsdue to thecomplication that thisbringsandtheimproperuseofdrugsasprophylaxisorattemptedtreatmentonlygeneratesselectivepressurethatleadstoanincreaseinresistanceasobservedin theisolated strainsin this study, where thevastmajoritypresentenzymesaswellasotherresistancemechanismsthatconferthemtobeXDrthere wasanincreasein thenumberofhealthcare-associatedinfectionsandbacteria showedgreaterresistance tobacteriaisolatedinsimilarpre-pandemicinfectionsHospitalreconversionandthepandemicappeartobeanimportantdriverofresistanceEthicalapprovalthestudydesignisretrospectivesonointerventionorintentionalmodificationismadein thephysiologicalpsychologicalorsocialvariablesintheindividualsparticipatinginthestudy,sotheethicscommitteedidnotrequireregistrationbutitdidapproveitsdevelopmentanddue to theaforementionedcharacteristicsinformedconsentwasomittedAcknowledgmentWethanktheinstitutionsthatsupportedincarryingoutthisresearch6REFERENCES1Ma Y, ZengH Zhan Zetal.2020CorticosteroidUseinthe TreatmentofCOVID-19AMulticenterRetrospectiveStudyinHunanChinaFrontPharmacol111198https://doiorg/103389/fphar2020011982Cisneros JRosso-Fernández MRoca-OportoCetal2019Colistinversusmeropenemin theempirical treatmentof ventilator-associatedpneumonia(MagicBulletstudy)aninvestigator-drivenopenlabelrandomizednoninferioritycontrolledtrialCritCare23383https://doiorg/101186/s13054-019-2627-y3KreitmannL,MonardCDauwalderOSimonMArgaudL,2020Earlybacterialco-infectioninARDSrelatedtoCOVID-19IntensiveCare Med461787-1789https://doiorg/101007/s00134-020-06165-54LangfordBSo MRaybardhanSetal.2020Bacterialco-infectionandsecondaryinfectioninpatientswithCOVID-19alivingrapidreviewandmeta-analysisClinMicrobiolInfect26(12)1622-1629doi101016/jcmi2020070165LiuCWenY,WanWLeiJJiangX2021ClinicalcharacteristicsandantibioticstreatmentinsuspectedbacterialinfectionpatientswithCOVID-19IntImmunopharmacol90107157https://doiorg/101016/jintimp20201071576Li J Wang J Yang Yetal.2020EtiologyandantimicrobialresistanceofsecondarybacterialinfectionsinpatientshospitalizedwithCOVID-19in WuhanChinaaretrospectiveanalysis AntimicrobAnotherlimitingpointofthepresentstudyisthelackofmanualandautomatedphenotypicandgenotypictestsforthedetectionofcolistinresistanceforwhichreasontheabsenceofPDrresistantPanDrug-resistantbacteriacannotbeassuredsincetheywerenotconsideredinthepresentstudy.butsomeofthePseudomonasaeruginosaandAcinetobacterbaumanniiculturesaftercolistintreatmentpersistedinsubsequentcontrolculturesWhichindicatespossiblemechanismsofresistance to thelastlineof treatmentIn this study, the targeted therapiesused for the treatmentofisolatedbacteriaarenotmentionedduetoalaterstudythatisintendedtoreporttoindicateresistancepatternsinlate-linedrugsfortheisolatesobtainedandthetherapeuticsuccessesorfailuresinadditiontotheconsiderationsthataretakenintoaccountinthechoiceofmedicationAsananalysisof thelogisticregression wehave the followingFindingthathavingapreviouschronicDiseasePreventionandcontrol(cncD)suchastype2diabetesmellitushypertensionorischemicdiseaseincreasestheriskby10345(Ic1127-94995)(timesmorelikelytodevelopEscherichiacoli.)On theotherhandanalyzing the factors thatareassociatedforthedevelopmentofinfectionbyAcinetobacterbaumanniibeingamanincreasesby19650(Ic1187-325389) theprobabilityofacquiring thediseasecompared tobeinga womanas wellashavingpositivesmokingincreasestheriskin31582(cI1469-679621)timeswithrespecttothosewhodonotsmokebeingstatisticallysignificantinbothcasesForthecaseofotherbacteria(E.clocae,S.epidermidis,S.haemolyticus,E.faecalis)thebodyweightclassifiedasnormalweightoverweightandobesitywasanalyzedFindingthathavinganormal weightreduces theriskofdevelopingabacterialpathologyby12345(Ic0009-0760)comparedtothosewhoareoverweightorobese5CONCLUSIONtheuseofprophylacticantibacterialtreatmentwithfluoroquinolonesandcephalosporinsdidnotrepresentanadvantagesince thepatientsacquiredabacterialcoinfectionwhere thestrainsareresistanttothesedrugsKnowingthelocalepidemiologyisofvitalimportancetobeabletodeterminethetreatmentsandsuspicionsofetiologicalagentsofassociatedinfectionsandtoprescribeanempiricaltreatmentasclosetothedirectedoneaspossiblenosocomialinfectionsareaproblem thatisleading to thedeathofpeopleinserioushealthconditionsintheIntensivecareUnits