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using thedoubledisc technique(11)On theotherhand for thedetectionofresistance tomethicillinin thecaseofStaphylococcus, thediffusiontestof1µgoxacillindiscswasusedaswellasthe30 µgcefoxitinscreening(1213)the strainsofPseudomonasaeruginosaand Stenotrophomonaswereconsidered XDrMDraccording to theclassificationissuedtotheamountofdrugsanddrugfamiliestowhichtheyshowresistance(14)StatisticanalysiscategoricalvariableswerereportedasfrequenciesandproportionsQuantitativevariableswerereportedusingmeanandstandarddeviationormedianandinterquartilerange(IQr)accordingtotheirobserveddistributionLogisticregressionanalysistoidentifythefactorsassociatedwiththesusceptibilityofacquitingbacterialinfection3RESULTSInthefollowingstudy,itwasdetectedthatallpatientsadmittedtotheIntensivecareUnitreceivedantibacterialtherapyasprophylaxisindicatingthird-generationcephalosporinsandfluoroquinolonesbythemedicalarea100%ofthestudysamplereceivedlevofloxacinand third-generationcephalosporins simultaneously,prior tobacterialinfectionorduring thecourseofaggregateinfectionDuringthestudyperiod150patientswereadmittedtotheintensivecareunitbut those who showedanaggregatebacterialinfectionrelatedtohealthcareornosocomialweretakenintoaccountforthisstudy.thedemographicdataandmaincharacteristicsof thepatientsunder study(n=100)arereportedin tablenumber1UnderthecriteriaestablishedfordataanalysisWhere60%of the samplecorresponds to themalegender,40%tothefemalegender.bothgenderswith100ÞathaftertheirhospitalstayintheIntensivecareUnittheaverageageofthestudypopulationis502withstandarddeviationof12146475%ofthepatientsadmittedtotheIntensivecareUnitreportapositivePcrtestwhile22%theresultispendingbythestatePublicHealthlaboratoryandonly3%haveanegativetestHowever,100%presentedaftertheirstayanaggregatedbacterialinfectionindependentoftheresultforthediseaseduetocovid-19Withinthebiologicalsamplesanalyzedthatcomprise46%bronchial secretion 32%expectoration6Êtheter tips9%bloodculture4%urinecultureand2%pleuralfluidthemainisolatedbacteriaarelistedintablenumber2Withahighincidenceofstaphylococcusaureus38%andPseudomonasaeruginosa236ANALESRANFwwwanalesranfcomResistencia alos antibióticoseninfecciones asociadas ala atencióndelasaludenlapandemiadeCOVID-19JorgeAAlmeidaVillegasJoséAGutiérrezGutiérrezetalAnRealAcadFarmVol88Nº2(2022)·pp123-130Gramnegativebacteriaare those that wereisolatedin thegreatestnumberwith55%and45%forGrampositivebacteriaHighlighting theabsenceof fungaldevelopmentsuchasCandidasppor Aspergillusspp.According to theresultsobtainedby theantibiogramsandtheclassificationmentionedinthemethodologyasExtendedspectrumbetalactamaseproducingbacteria(EsbL)MethicillinresistantStaphylococcusaureus(MrsA)MultidrugresistantbacteriaandExtremelyDrugresistantbacteriaarereportedin the tablenumber3 With84%ofExtremelydrugresistantand12%ofMultidrugresistantincluding thosebacteriaresistant tomethicillinorproducingEsbLAccording to theresultsof theantibiogramsissuedby themicrobiologydepartmentusingMIcsissuedby thecLsIa significantnumberofstrainswithhighresistancetoantibioticsarereportedasshowninthetableWhereantibioticsarecategorizedasbetalactams;penicillinanditsderivativescephalosporinsandcarbapenemsthefloroquinolones;levofloxacinciprofloxacinmofloxacintheaminoglycosides;amikacinandgentamicintetracyclines;tetracyclineand tigecyclineandsomeotherdrugs withdifferentclassificationssuchasglycopeptidesmacrolideslincosaminesamongothersTable2FrequencyofbacteriaidentifiedinthepatientsevaluatedbacteriaIdentifiedn(%)Staphylococcusaureus38(380)Stenotrophomonasmaltophilia20(200)Pseudomonasaeuroginosa23(230)Escherichiacoli6(60)Acinetobacterbaumannii5(50)Other8(80)OtherE.clocae,S.epidermis,E.faecalis,S.haemolyticus.Table3Classificationofmechanismsand typesofresistanceAntibióticototalnsusceptiblesn(%)MrsA3838(100)EsbL77(100)XDr84100(84)MDr12100(12)Extended spectrumbetalactamase(EsbL)Methicillinresistant Staphylococcusaureus(MrsA)Multidrugresistant(MDr)andExtremelyDrugresistant(XDr)