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ANALES
RANF
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5. CONCLUSIÓN
Los datos presentados demuestran que la proteína
obtenida a partir de la secuencia ancestral reconstruida Anc 26 es
activa y muestra resistencia a varios antibióticos. esta secuencia
muestra niveles de resistencia frente a cAZ mayores que cualquiera
de las ß-lactamasas actuales estudiadas. Los datos obtenidos con-
firman que las proteínas ancestrales son más generalistas que las
proteínas actuales, esta estrategia podría servir como un punto de
partida prometedor para la obtención de proteínas de interés biotec-
nológico, ya que la promiscuidad es una de las principales carac-
terísticas a la hora de producir nuevas proteínas mediante evolución
in vitro de proteínas (50).
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