Page 106 - 87_01
P. 106

Applications of Quantitative Systems Pharmacology in model-infor-                                                        ANALES
     med drug discovery: Perspective on impact and opportunities. CPT                                                            RANF
     Pharmacometrics Syst Pharmacol. 2019;8:777-791.
20. Janiaud P, Serghiou S and Ioannidis JPA. New clinical trial designs                                                                   www.analesranf.com
     in the era of precision medicine: An overview of definitions, strengths,
     weaknesses, and current use in oncology. Cancer Treat Rev.                                                           Si desea citar nuestro artículo:
     2019;73:20-30.                                                             Productos Naturales: De la medicina tradicional a cabezas
21. Machado H, Tuttle RN and Jensen PR. Omics-based natural product            de serie para el desarrollo de nuevos fármacos del siglo XXI
     discovery and the lexicon of genome mining. Curr Opin Microbiol.
     2017;39:136-142.                                                                                                           Beatriz de las Heras Polo
22. Khaw KY, Parat MO, Shaw PN and Falconer JR. Solvent supercritical                                                      An Real Acad Farm [Internet].
     fluid technologies to extract bioactive compounds from natural sour-                        An. Real Acad. Farm. Vol. 87. Nº 1 (2021) · pp. 97 -104
     ces: A review. Molecules. 2017;22:1186.
23. Duarte Y, Marquez-Miranda V, Miossec MJ and Gonzalez-Nilo F. In-                                                                         DOI: http://
     tegration of target discovery, drug discovery and drug delivery: A
     review on computational strategies. Wiley Interdiscip Rev Nanomed
     Nanobiotechnol. 2019;11:e1554.
24. Atanasov AG, Zotchev SB and Dirsch VM. Natural products in drug
     discovery: advances and opportunities. Nat Rev Drug Discov.
     2021;20:200-216.
25. Schneider P, Walters WP, Plowright AT, Sieroka N, Listgarten J, Go-
     odnow RA, Jr., Fisher J, Jansen JM, Duca JS, Rush TS, Zentgraf M,
     Hill JE, Krutoholow E, Kohler M, Blaney J, Funatsu K, Luebkemann
     C and Schneider G. Rethinking drug design in the artificial intelli-
     gence era. Nat Rev Drug Discov. 2020;19:353-364.
26. Tung CW. Public databases of plant natural products for computa-
     tional drug discovery. Curr Comput Aided Drug Des. 2014;10:191-
     196.
27. Fang J, Liu C, Wang Q, Lin P and Cheng F. In silico polypharmacology
     of natural products. Brief Bioinform. 2018;19:1153-1171.
28. Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A
     and Dzobo K. Natural products for drug discovery in the 21st century:
     Innovations for novel drug discovery. Int J Mol Sci. 2018;19:1578.
29. Wolfender JL, Litaudon M, Touboul D and Queiroz EF. Innovative
     omics-based approaches for prioritisation and targeted isolation of
     natural products - new strategies for drug discovery. Nat Prod Rep.
     2019;36:855-868.
30. Atanasov AG, Yeung AWK and Banach M. Natural products for tar-
     geted therapy in precision medicine. Biotechnol Adv.
     2018;36:1559-1562.

104  Natural products: from traditional medicine to lead compounds for drug

     development in the 21st century

     beatriz de las heras
     an. real acad. farm. vol. 87. nÀ1 (2021) · pp. 97 - 104
   101   102   103   104   105   106   107   108   109   110   111