Page 11 - 80_03
P. 11
M.
C.
Avendaño
López
REFERENCIAS
1.
Suzuki,
S.;
Li,
X.
K.;
Enosawa,
S.;
Shinomiya,
T.
“A
new
immunosuppressant:
FTY720,
induces
bcl--2--associated
apoptotic
cell
death
in
human
lymphocytes”
Immunology
1996,
89,
518--
523.
2.
a)
Adachi,
K.;
Kohara,
T.;
Nakao,
N.;
Arita,
M.;
Chiba,
K.;
Mishina,
T.;
Sasaki,
S.;
Fujita,
T.
“Design,
synthesis
and
structure--activity
relationships
of
2--substituted
2--amino--1,3--
propanediols:
Discovery
of
a
novel
immunosuppressant,
FTY720”
Bioorg.
Med.
Chem.
Lett.
1995,
5,
853--856.
b)
Fujita,
T.;
Hirose,
R.;
Yoneta,
M.;
Sasaki,
S.;
Inoue,
K.;
Kiuchi,
M.;
Hirase,
S.;
Chiba,
K.;
Sakamoto,
H.;
Arita,
M.
“Potent
immunosuppressants,
2--alkyl--2--
aminopropane--1,3--diols”
J.
Med.
Chem.
1996,
39,
4451--4459.
4.
Brinkmann,
V.
“Sphingosine
1--phosphate
receptors
in
health
and
disease:
mechanistic
insights
from
gene
deletion
studies
and
reverse
pharmacology”
Pharmacol.
Ther.
2007,
115,
84--105.
5.
Matloubian,
M.;
Lo,
C.
G.;
Cinamon,
G.;
Lesneski,
M.
J.;
Xu,
Y.;
Brinkmann,
V.;
Allende,
M.
L.;
Proia,
R.
L.;
Cyster,
J.
G.
“Lymphocyte
egress
from
thymus
and
peripheral
lymphoid
organs
is
dependent
on
S1P
receptor
1”
Nature
2004,
427,
355--360.
6.
a)
Albert,
R.;
Hinterding,
K.;
Brinkmann,
V.;
Guerini,
D.;
Müller--Hartwieg,
C.;
Knecht,
H.;
Simeon,
C.;
Streiff,
M.;
Wagner,
T.;
Welzenbach,
K.;
Zecri,
F.;
Zollinger,
M.;
Cooke,
N.;
Francotte,
E.
“Novel
immunomodulator
FTY720
is
phosphorylated
in
rats
and
humans
to
form
a
single
stereoisomer.
Identification:
chemical
proof,
and
biological
characterization
of
the
biologically
active
species
and
its
enantiomer”
J.
Med.
Chem.
2005,
48,
5373--5377.
b)
Bandhuvula,
P.;
Tam,
Y.
Y.;
Oskouian,
B.;
Saba,
J.
D.
“The
immune
modulator
FTY720
inhibits
sphingosine--1--phosphate
lyase
activity”
J.
Biol.
Chem.
2005,
280,
33697--33700.
7.
Seder,
R.
A.;
Darrah,
P.
A.;
Roederer,
M.
“T--cell
quality
in
memory
and
protection:
implications
for
vaccine
design”
Nat.
Rev.
Immunol.
2008,
8,
247--259.
8.
Pham,
T.
H.;
Okada,
T.;
Matloubian,
M.;
Lo,
C.
G.;
Cyster,
J.
G.
“S1P1
receptor
signaling
overrides
retention
mediated
by
Gai--coupled
receptors
to
promote
T
cell
egress”
Immunity
2008,
28,
122--133.
9.
a)
Metzler,
B.;
Gfeller,
P.;
Wieczorek,
G.;
Li,
J.;
Nuesslein--Hildesheim,
B.;
Katopodis,
A.;
Mueller,
M.;
Brinkmann,
V.
“Modulation
of
T
cell
homeostasis
and
alloreactivity
under
continuous
FTY720
exposure”
Int.
Immunol.
2008,
20,
633--644.
b)
Pham,
T.
H.;
Baluk,
P.;
Xu,
Y.;
Grigorova,
I.;
Bankovich,
A.
J.;
Pappu,
R.;
Coughlin,
S.
R.;
McDonald,
D.
M.;
Schewab,
S.
R.;
Cyster,
J.
C.
“Lymphatic
endothelial
cell
sphingosine
kinase
activity
is
required
for
lymphocyte
egress
and
lymphatic
patterning”
J.
Exp.
Med.
2010,
207,
17--27.
10.
Kunzendorf,
U.;
Ziegler,
E.;
Kabelitz,
D.
“FTY720--the
first
compound
of
a
new
promising
class
of
immunosuppressive
drugs”
Nephrol.
Dial.
Transplant
2004,
19,
1677--1681.
11.
a)
Matsuura,
M.;
Imayoshi,
T.;
Chiba,
K.;
Okumoto,
T.
“Effect
of
FTY720,
a
novel
immunosuppressant,
on
adjuvant--induced
arthritis
in
rats”
Inflamm.
Res.
2000,
49,
404--
410.
b)
Kitabayashi,
H.;
Isobe,
M.;
Watanabe,
N.;
Suzuki,
J.;
Yazaki,
Y.;
Sekiguchi,
M.
“FTY720
prevents
development
of
experimental
autoimmune
myocarditis
through
reduction
of
circulating
lymphocytes”
J.
Cardiovasc.
Pharmacol.
2000,
35,
410--416.
c)
Kohno,
T.;
Tsuji,
T.;
Hirayama,
K.;
Watanabe,
K.;
Matsumoto,
A.;
Kohno,
T.;
Fujita,
T.
“A
novel
immunomodulator,
FTY720,
prevents
spontaneous
dermatitis
in
NC/Nga
mice”
Biol.
Pharm.
Bull.
2004,
27,
1392--1396.
d)
Mansoor,
M.;
Meléndez,
A.
J.
“Recent
trials
for
FTY720
(fingolimod):
a
new
generation
of
immunomodulators
structurally
similar
to
sphingosine”
Rev.
Recent
Clin.
Trials
2008,
3,
62--69.
12.
a)
Balatoni,
B.;
Storch,
M.
K.;
Swoboda,
E.
M.;
Schönborn,
V.;
Koziel,
A.;
Lambrou,
Balatoni,
B.;
Storch,
M.K.;
Swoboda,
E.M.;
Schonborn,
V.;
Koziel,
A.;
Lambrou,
G.N.;
Hiestand,
P.C.;
Weissert,
R.;
Foster,
C.A.
“FTY720
sustains
and
restores
neuronal
function
in
the
DA
rat
model
of
MOG--induced
experimental
autoimmune
encephalomyelitis”
Brain
Res.
Bull.
2007,
74,
307--316.
b)
Webb,
M.;
Tham,
C.
S.;
Lin,
F.
F.;
Lariosa--Willingham,
K.Yu,
N.;
Hale,
J.;
Mandala,
S.;
Chun,
J.;
Rao,
T.
S.
“Sphingosine
1--phosphate
receptor
agonists
attenuate
relapsing--remitting
experimental
autoimmune
encephalitis
in
SJL
mice”
J.
Neuroimmunol.
2004,153,108--121.
c)
Kataoka,
H.;
Sugahara,
K.;
Shimano,
K.;
Teshima,
K.;
Koyama,
M.;
Fukunari,
A.;
Chiba,
K.
“FTY720:
sphingosine
1--phosphate
receptor
modulator,
ameliorates
experimental
autoimmune
encephalomyelitis
by
inhibition
of
T
cell
infiltration”
Cell
Mol.
Immunol.
2005,
2,
439--448.
13.
a)
Brinkmann,
V.;
Billich,
A.;
Baumruker,
T.;
Heining,
P.;
Schmouder,
R.;
Francis,
G.;
464
