Page 44 - 79_03
P. 44
J.
C.
Rodríguez
Rey
7. Randle,
P.J.,
Garland,
P.B.,
Hales,
C.N.,
and
Newsholme,
E.A.
1963.
The
glucose
fatty--acid
cycle.
Its
role
in
insulin
sensitivity
and
the
metabolic
disturbances
of
diabetes
mellitus.
Lancet
1:785--789.
8. Hue,
L.,
and
Taegtmeyer,
H.
2009.
The
Randle
cycle
revisited:
a
new
head
for
an
old
hat.
Am
J
Physiol
Endocrinol
Metab
297:E578--591.
9. Jucker,
B.M.,
Rennings,
A.J.,
Cline,
G.W.,
and
Shulman,
G.I.
1997.
13C
and
31P
NMR
studies
on
the
effects
of
increased
plasma
free
fatty
acids
on
intramuscular
glucose
metabolism
in
the
awake
rat.
J
Biol
Chem
272:10464--10473.
10. Saha,
A.K.,
Schwarsin,
A.J.,
Roduit,
R.,
Masse,
F.,
Kaushik,
V.,
Tornheim,
K.,
Prentki,
M.,
and
Ruderman,
N.B.
2000.
Activation
of
malonyl--CoA
decarboxylase
in
rat
skeletal
muscle
by
contraction
and
the
AMP--activated
protein
kinase
activator
5--aminoimidazole--4--
carboxamide--1--beta
--D--ribofuranoside.
J
Biol
Chem
275:24279--24283.
11. Riancho,
J.A.,
Vazquez,
L.,
Garcia--Perez,
M.A.,
Sainz,
J.,
Olmos,
J.M.,
Hernandez,
J.L.,
Perez--
Lopez,
J.,
Amado,
J.A.,
Zarrabeitia,
M.T.,
Cano,
A.,
et
al.
2011.
Association
of
ACACB
polymorphisms
with
obesity
and
diabetes.
Mol
Genet
Metab
104:670--676.
12. McGarry,
J.D.
2002.
Banting
lecture
2001:
dysregulation
of
fatty
acid
metabolism
in
the
etiology
of
type
2
diabetes.
Diabetes
51:7--18.
13. Rothman,
D.L.,
Magnusson,
I.,
Cline,
G.,
Gerard,
D.,
Kahn,
C.R.,
Shulman,
R.G.,
and
Shulman,
G.I.
1995.
Decreased
muscle
glucose
transport/phosphorylation
is
an
early
defect
in
the
pathogenesis
of
non--insulin--dependent
diabetes
mellitus.
Proc
Natl
Acad
Sci
U
S
A
92:983--
987.
14. Rothman,
D.L.,
Shulman,
R.G.,
and
Shulman,
G.I.
1992.
31P
nuclear
magnetic
resonance
measurements
of
muscle
glucose--6--phosphate.
Evidence
for
reduced
insulin--dependent
muscle
glucose
transport
or
phosphorylation
activity
in
non--insulin--dependent
diabetes
mellitus.
J
Clin
Invest
89:1069--1075.
15. Shulman,
G.I.,
Rothman,
D.L.,
Jue,
T.,
Stein,
P.,
DeFronzo,
R.A.,
and
Shulman,
R.G.
1990.
Quantitation
of
muscle
glycogen
synthesis
in
normal
subjects
and
subjects
with
non--
insulin--dependent
diabetes
by
13C
nuclear
magnetic
resonance
spectroscopy.
N
Engl
J
Med
322:223--228.
16. Brechtel,
K.,
Dahl,
D.B.,
Machann,
J.,
Bachmann,
O.P.,
Wenzel,
I.,
Maier,
T.,
Claussen,
C.D.,
Haring,
H.U.,
Jacob,
S.,
and
Schick,
F.
2001.
Fast
elevation
of
the
intramyocellular
lipid
content
in
the
presence
of
circulating
free
fatty
acids
and
hyperinsulinemia:
a
dynamic
1H--
MRS
study.
Magn
Reson
Med
45:179--183.
17. Roden,
M.,
Price,
T.B.,
Perseghin,
G.,
Petersen,
K.F.,
Rothman,
D.L.,
Cline,
G.W.,
and
Shulman,
G.I.
1996.
Mechanism
of
free
fatty
acid--induced
insulin
resistance
in
humans.
J
Clin
Invest
97:2859--2865.
18. Cline,
G.W.,
Petersen,
K.F.,
Krssak,
M.,
Shen,
J.,
Hundal,
R.S.,
Trajanoski,
Z.,
Inzucchi,
S.,
Dresner,
A.,
Rothman,
D.L.,
and
Shulman,
G.I.
1999.
Impaired
glucose
transport
as
a
cause
of
decreased
insulin--stimulated
muscle
glycogen
synthesis
in
type
2
diabetes.
N
Engl
J
Med
341:240--246.
19. McCarthy,
M.I.
2010.
Genomics,
type
2
diabetes,
and
obesity.
N
Engl
J
Med
363:2339--2350.
20. Watson,
R.T.,
and
Pessin,
J.E.
2006.
Bridging
the
GAP
between
insulin
signaling
and
GLUT4
translocation.
Trends
Biochem
Sci
31:215--222.
21. Watson,
R.T.,
Kanzaki,
M.,
and
Pessin,
J.E.
2004.
Regulated
membrane
trafficking
of
the
insulin--responsive
glucose
transporter
4
in
adipocytes.
Endocr
Rev
25:177--204.
22. Sun,
X.J.,
Rothenberg,
P.,
Kahn,
C.R.,
Backer,
J.M.,
Araki,
E.,
Wilden,
P.A.,
Cahill,
D.A.,
Goldstein,
B.J.,
and
White,
M.F.
1991.
Structure
of
the
insulin
receptor
substrate
IRS--1
defines
a
unique
signal
transduction
protein.
Nature
352:73--77.
23. White,
M.F.
2002.
IRS
proteins
and
the
common
path
to
diabetes.
Am
J
Physiol
Endocrinol
Metab
283:E413--422.
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