Page 101 - 79_02
P. 101

Long-­-life	
  supplementation	
  with	
  atenolol…	
  	
  

	
  

     18.	
   Hulbert,	
   A.J.	
   Metabolism	
   and	
   longevity:	
   Is	
   there	
   a	
   role	
   for	
   membrane	
   fatty	
   acids?	
   Integr	
  
          Comp	
  Biol	
  2010;	
  50,	
  808-­-17	
  

     19.	
   Naudi,	
   A.;	
   Jove,	
   M.;	
   Ayala,	
   V.;	
   Portero-­-Otin,	
   M.;	
   Barja,	
   G.;	
   Pamplona,	
   R.	
   Regulation	
   of	
  
          membrane	
   unsaturation	
   as	
   antioxidant	
   adaptive	
   mechanism	
   in	
   long-­-lived	
   animal	
   species.	
  
          Free	
  Rad	
  Antiox	
  2011;	
  1,	
  3-­-12.	
  

     20.	
   Liang,	
   H.;	
   Masoro,	
   Nelson,	
   J.F.;	
   Strong,	
   R.;	
   McMahan,	
   C.A.;	
   Richardson,	
   A.	
   Genetic	
   mouse	
  
          models	
  of	
  extended	
  lifespan.	
  Exp	
  Gerontol,	
  2003;	
  38,	
  1353–1364	
  

     21.	
   Selman,	
   C.;	
   Withers,	
   D.J.	
   Mammalian	
   models	
   of	
   extended	
   healthy	
   lifespan.	
   Philos	
   Trans	
   R	
  
          Soc	
  Lond	
  B	
  Biol	
  Sci	
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  366,	
  99-­-107	
  

     22.	
   Narasimhan,	
   S.D.;	
   Yen,	
   K.;	
   Tissenbaum,	
   H.A.	
   Converging	
   pathways	
   in	
   lifespan	
   regulation.	
  
          Curr	
  Biol,	
  2009;	
  19,	
  657-­-6	
  

     23.	
   Benigni,	
   A.;	
   Corna,	
   D.;	
   Zoja,	
   C.;	
   Sonzogni,	
   A.;	
   Latini,	
   R.;	
   Salio,	
   M.;	
   Conti,	
   S.;	
   Rottoli,	
   D.;	
  
          Longaretti,	
  L.;	
  Cassis,	
  P.;	
  Morigi,	
  M.;	
  Coffman,	
  T.M.;	
  Remuzzi,	
  G. Disruption	
  of	
  the	
  Ang	
  II	
  
          type	
  1	
  receptor	
  promotes	
  longevity	
  in	
  mice.	
  J.	
  Clin.	
  Invest.	
  2009;	
  119,	
  524–530	
  	
  

     24.	
   Porter,	
   A.G.;	
   Urbano,	
   A.G.	
   Does	
   apoptosis-­-inducing	
   factor	
   (AIF)	
   have	
   both	
   life	
   and	
   death	
  
          functions	
  in	
  cells?	
  Bioessays	
  2006;	
  28,	
  834-­-843	
  

     25.	
   Donmez,	
   G.;	
   Guarente,	
   L.	
   Aging	
   and	
   disease:	
   connections	
   to	
   sirtuins.	
   Aging	
   Cell	
   2010;	
   9,	
  
          285-­-290	
  

     26.	
   Mela,	
   L.;	
   Seitz,	
   S.	
   Isolation	
   of	
   mitochondria	
   with	
   emphasis	
   on	
   heart	
   mitochondria	
   from	
  
          small	
  amounts	
  of	
  tissue.	
  Methods	
  Enzymol	
  1997;	
  55,	
  39-­-46	
  

     27.	
   Barja,	
   G.;	
   The	
   quantitative	
   measurement	
   of	
   H2O2	
   generation	
   in	
   isolated	
   mitochondria.	
   J	
  
          Bioenerg	
  Biomembr	
  2002;	
  34,	
  227-­-233	
  

     28.	
  Gredilla,	
  R.;	
  Sanz,	
  A.;	
  Lopez-­-Torres,	
  M.;	
  Barja,	
  G.	
  Caloric	
  restriction	
  decreases	
  mitochondrial	
  
          free	
  radical	
  generation	
  at	
  Complex	
  I	
  and	
  lowers	
  oxidative	
  damage	
  to	
  mitochondrial	
  DNA	
  in	
  
          the	
  rat	
  heart.	
  FASEB	
  J	
  2001;	
  15,	
  1589-­-1591	
  

     29.	
   Latorre,	
   A.;	
   Moya,	
   A.;	
   Ayala,	
   A.	
   Evolution	
   of	
   mitochondrial	
   DNA	
   in	
   Drosophila	
   suboscura.	
  
          Proc	
  Natl	
  Acad	
  Sci	
  USA	
  1986;	
  83,	
  8649-­-8653	
  

     30.	
   Asuncion,	
   J.C.;	
   Millan,	
   A.;	
   Pla,	
   R.;	
   Bruseghini,	
   L.;	
   Esteras,	
   A.,	
   Pallardo,	
   F.V.;	
   Sastre,	
   J.;	
   Viña,	
   J.	
  
          Mitochondrial	
   glutathione	
   oxidation	
   correlates	
   with	
   age-­-associated	
   oxidative	
   damage	
   to	
  
          mitochondrial	
  DNA.	
  FASEB	
  J	
  1996;	
  10,	
  333-­-338	
  

     31.	
   Barja	
   G.;	
   Herrero	
   A.	
   Oxidative	
   damage	
   to	
   mitochondrial	
   DNA	
   is	
   inversely	
   related	
   to	
  
          maximum	
  life	
  span	
  in	
  the	
  heart	
  and	
  brain	
  of	
  mammals,	
  FASEB	
  J,	
  2000;	
  14,	
  312-­-318	
  	
  

     32.	
  Pamplona,	
  R.;	
  Dalfó,	
  E.;	
  Ayala,	
  V.;	
  Bellmunt,	
  MJ.;	
  Prat,	
  J.;	
  Ferrer,	
  I.;	
  Portero-­-Otín,	
  M.	
  Proteins	
  
          in	
  human	
  brain	
  cortex	
  are	
  modified	
  by	
  oxidation,	
  glycoxidation,	
  and	
  lipoxidation.	
  Effects	
  of	
  
          Alzheimer	
   disease	
   and	
   identification	
   of	
   lipoxidation	
   targets.	
   J	
   Biol	
   Chem.	
   2005;	
   280(22),	
  
          21522-­-30.	
  

     33.	
  Caro,	
  P.;	
  Gomez,	
  J.;	
  Sanchez,	
  I.;	
  Naudi,	
  A.;	
  Ayala,	
  V.;	
  López-­-Torres,	
  M.;	
  Pamplona,	
  R.;	
  Barja,	
  G.	
  
          Forty	
   percent	
   methionine	
   restriction	
   decreases	
   mitochondrial	
   oxygen	
   radical	
   production	
  
          and	
   leak	
   at	
   complex	
   I	
   during	
   forward	
   electron	
   flow	
   and	
   lowers	
   oxidative	
   damage	
   to	
  
          proteins	
   and	
   mitochondrial	
   DNA	
   in	
   rat	
   kidney	
   and	
   brain	
   mitochondria.	
   Rejuvenation	
   Res.	
  
          2009;	
  12(6),	
  421-­-34.	
  

     34.	
   Pamplona,	
   R.;	
   Barja,	
   G.;	
   Portero-­-Otín,	
   M.	
   Membrane	
   fatty	
   acid	
   unsaturation,	
   protection	
  
          against	
   oxidative	
   stress,	
   and	
   maximum	
   life	
   span:	
   a	
   homeoviscous-­-longevity	
   adaptation.	
  
          Ann	
  New	
  York	
  Acad	
  Sci	
  2002;	
  959,	
  475-­-490	
  

     35.	
   Hulbert,	
   A.J.;	
   Pamplona,	
   R.;	
   Buffestein,	
   R.;	
   Buttemer,	
   W.A.	
   Life	
   and	
   death:	
   metabolic	
   rate,	
  
          membrane	
   composition	
   and	
   life	
   span	
   of	
   animals.	
   Physiological	
   Reviews	
   2007;	
   87,	
   1175-­-
          1213	
  

     36.	
   López-­-Torres,	
   M.;	
   G.	
   Barja,	
   G.	
   Lowered	
   methionine	
   ingestion	
   as	
   responsible	
   for	
   the	
  
          decrease	
   in	
   rodent	
   mitochondrial	
   oxidative	
   stress	
   in	
   protein	
   and	
   dietary	
   restriction.	
  
          Possible	
  implications	
  for	
  humans.	
  Biochim	
  Biophys	
  Acta	
  2008;	
  1780,	
  1337-­-1347	
  

                                                                                                                            	
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