Page 100 - 79_02
P. 100

A.	
  Gómez	
  et	
  col.	
  

	
  
7.	
  REFERENCES	
  

     1.	
  Yan,	
  L.;	
  D.E.	
  Vatner,	
  D.E.;	
  O’Connor,	
  J.P.;	
  Ivessa,	
  A.;	
  Ge,	
  H.;	
  Chen,	
  W.;	
  Hirotani,	
  S.;	
  Ishikawa,	
  Y.;	
  
          Sadoshima,	
   J.;	
   Vatner,	
   S.F.	
   Type	
   5	
   adenylyl	
   cyclase	
   disruption	
   increases	
   longevity	
   and	
  
          protects	
  against	
  stress.	
  Cell,	
  2007;	
  130,	
  247–258.	
  

     2.	
   Sanchez-­-Roman,	
   I.;	
   Gomez,	
   J.;	
   Naudi,	
   A.;	
   Ayala,	
   V.;	
   Portero-­-Otín,	
   M.;	
   Lopez-­-Torres,	
   M.;	
  
          Pamplona,	
   R.;	
   Barja,	
   G.	
   The	
   beta-­-blocker	
   atenolol	
   lowers	
   the	
   longevity-­-related	
   degree	
   of	
  
          fatty	
   acid	
   unsaturation,	
   decreases	
   protein	
   oxidative	
   damage,	
   and	
   increases	
   extracellular	
  
          signal-­-regulated	
   kinase	
   signaling	
   in	
   the	
   heart	
   of	
   C57BL/6	
   mice.	
   Rejuv	
   Res	
   2010;	
   13,	
   683–
          693	
  	
  

     3.	
   Barja,	
   G.;	
   Cadenas,	
   S.;	
   Rojas,	
   C.;	
   Pérez-­-Campo,	
   R.;	
   López-­-Torres,	
   M.	
   Low	
   mitochondrial	
   free	
  
          radical	
   production	
   per	
   unit	
   O2	
   consumption	
   can	
   explain	
   the	
   simultaneous	
   presence	
   of	
  
          high	
  longevity	
  and	
  high	
  aerobic	
  metabolic	
  rate	
  in	
  birds.	
  Free	
  Radic	
  Res	
  1994,	
  21,	
  317–327	
  

     4.	
   Barja,	
   G.;	
   Mitochondrial	
   oxygen	
   consumption	
   and	
   reactive	
   oxygen	
   species	
   production	
   are	
  
          independently	
  modulated:	
  implications	
  for	
  aging	
  studies.	
  Rejuv	
  Res	
  2007;	
  10,	
  215–224	
  

     5.	
   Pamplona,	
   R.;	
   Portero	
   Otín,	
   M.;	
   Riba,	
   D.;	
   Ruiz,	
   C.;	
   Prat,	
   J.;	
   Bellmunt,	
   M.J.;	
   Barja,	
   G.	
  
          Mitochondrial	
  membrane	
  peroxidizability	
  index	
  is	
  inversely	
  related	
  to	
  maximum	
  life	
  span	
  
          in	
  mammals.	
  J	
  Lipid	
  Res	
  1998;	
  39,	
  1989-­-94	
  

     6.	
   Hulbert,	
   A.J.;	
   Pamplona,	
   R.;	
   Buffestein,	
   R.;	
   Buttemer,	
   W.A.	
   Life	
   and	
   death:	
   metabolic	
   rate,	
  
          membrane	
   composition	
   and	
   life	
   span	
   of	
   animals.	
   Physiological	
   Reviews	
   2007;	
   87,	
   1175-­-
          1213	
  

     7.	
  Hagopian,	
  K.;	
  Chen,	
  Y.;	
  Simmons	
  Domer,	
  K.;	
  Soo	
  Hoo,	
  R.;	
  Bentley,	
  T.;	
  McDonald,	
  R.B.;	
  Ramsey,	
  
          J.J.	
   Caloric	
   restriction	
   influences	
   hydrogen	
   peroxide	
   generation	
   in	
   mitochondrial	
   sub-­-
          populations	
  from	
  mouse	
  liver.	
  J	
  Bioenerg	
  Biomembr	
  2011;	
  43,	
  227-­-36	
  

     8.	
  Gredilla,	
  R.;	
  Barja,	
  G.	
  Caloric	
  restriction,	
  aging	
  and	
  oxidative	
  stress.	
  Endocrinology	
  2005;	
  146,	
  
          3713–3717	
  

     9.	
   Sanz,	
   A.;	
   Caro,	
   P.;	
   Barja,	
   G.	
   Protein	
   restriction	
   without	
   strong	
   caloric	
   restriction	
   decreases	
  
          mitochondrial	
   oxygen	
   radical	
   production	
   and	
   oxidative	
   DNA	
   damage	
   in	
   rat	
   liver.	
   J	
  
          Bioenerg	
  Biomembr	
  2004;	
  36,	
  545–552	
  

     10.	
  Sanz,	
  A.;	
  Caro,	
  P.;	
  Ayala,	
  V.;	
  Portero-­-Otin,	
  M.;	
  Pamplona,	
  R.;	
  Barja,	
  G.	
  Methionine	
  restriction	
  
          decreases	
   mitochondrial	
   oxygen	
   radical	
   generation	
   and	
   leak	
   as	
   well	
   as	
   oxidative	
   damage	
  
          to	
  mitochondrial	
  DNA	
  and	
  proteins.	
  FASEB	
  J	
  2006a;	
  20,	
  1064–1073	
  

     11.	
  Maresca,	
  B.,	
  Cossins,	
  A.R.	
  Fatty	
  acid	
  feedback	
  and	
  fluidity.	
  Nature	
  1993;	
  365,	
  606–607.	
  

     12.	
  Hoch,	
  F.L.	
  Cardiolipins	
  and	
  membrane	
  function.	
  Biochim.	
  Biophys	
  Acta	
  1992;	
  1113,	
  71–133.	
  

     13.	
  Pamplona,	
  R.;	
  Portero-­-Otín,	
  M.;	
  Sanz,	
  A.;	
  Requena,	
  J.;	
  Barja,	
  G.	
  Modification	
  of	
  the	
  longevity-­-
          related	
   degree	
   of	
   fatty	
   acid	
   unsaturation	
   modulates	
   oxidative	
   damage	
   to	
   proteins	
   and	
  
          mitochondrial	
  DNA	
  in	
  liver	
  and	
  brain.	
  Experimental	
  Gerontology	
  2004;	
  39,	
  725–733	
  

     14.	
   Sato,	
   A.,	
   Huang,	
   M.Z.,	
   Watanabe,	
   S.,	
   Okuyama,	
   H.,	
   Nakamoto,	
   H.,	
   Rada´k,	
   Z.,	
   Goto,	
   S.	
   Protein	
  
          carbonyl	
   content	
   roughly	
   reflects	
   the	
   unsaturation	
   of	
   lipids	
   in	
   skeletal	
   muscle	
   but	
   not	
   in	
  
          other	
   tissues	
   of	
   stroke-­-prone	
   spontaneously	
   hypertensive	
   strain	
   (SHRSP)	
   rats	
   fed	
  
          different	
  fats	
  and	
  oils.	
  Biol.	
  Pharm.	
  Bull.	
  1998;	
  21,	
  1271–1276.	
  

     15.	
  Moreau,	
  R.;	
  Nguyen,	
  BT.;	
  Doneanu,	
  CE.;	
  Hagen,	
  T.M.	
  Reversal	
  by	
  aminoguanidine	
  of	
  the	
  age-­-
          related	
  increase	
  in	
  glycoxidation	
  and	
  lipoxidation	
  in	
  the	
  cardiovascular	
  system	
  of	
  Fischer	
  
          344	
  rats.	
  Biochem	
  Pharmacol,	
  2005;	
  69,	
  29–40.	
  

     16.	
   Pratt,	
   D.A.;	
   Tallman,	
   K.A.;	
   Porter,	
   N.A.	
   Free	
   Radical	
   Oxidation	
   of	
   Polyunsaturated	
   Lipids:	
  
          New	
   Mechanistic	
   Insights	
   and	
   the	
   Development	
   of	
   Peroxyl	
   Radical	
   Clocks.	
   Acc	
  Chem	
  Res,	
  
          2011;	
  44,	
  458-­-67.	
  

     17.	
   Holman,	
   R.T.	
   Autoxidation	
   of	
   fats	
   and	
   related	
   substances.	
   In:	
   Holman	
   RT,	
   Lundberg	
   WO,	
  
          Malkin	
   T	
   (eds)	
   Progress	
   in	
   chemistry	
   of	
   fats	
   and	
   other	
   lipids.	
   Pergamon	
   Press,	
   London,	
  
          1954;	
  51–98	
  

270	
  	
  

	
  
   95   96   97   98   99   100   101   102   103   104   105