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REVISIÓN(
Química(Farmacéutica(de(las(Acilaminometilpiridinas(
Miguel(Fernández(Braña1*,(Yolanda(Martín?Cantalejo2,(Marina(Gordaliza3,(Ana(
Sánchez?Migallón4(
1Académico* Correspondiente* de* la* Real* Academia* Nacional* de* Farmacia.* 2Departamento* de* Ciencias.*
Escuela* Politécnica.* Universidad* Europea* de* Madrid.* 3Facultad* de* Farmacia.* Instituto* de* Estudios* de* la*
Ciencia* y* la* Técnica.* Universidad* de* Salamanca.* 4Departamento* de* Química.* Universidad* de* Castilla* La*
Mancha.*
Recibido*el**5*de*mayo*de*2011.*
eLmail:*mifbrana@gmail.com*
RESUMEN(
Se( han( sintetizado( una( nueva( familia( de( depresores( del( Sistema( Nervioso( Central,(
basado( en( un( sistema( denominado( actualmente( la( “utilización( de( fragmentos”.( A(
uno(de(los(fármacos(obtenidos(por(este(procedimiento(la(OMS(le(asignó(el(nombre(
de( picobenzida.( Al( tratarse( de( una( benzamida( sustituida( se( prepararon( análogos(
modificando( los( sustituyentes( del( anillo( aromático( y( se( llevó( a( cabo( un( estudio(
QSAR( de( la( serie,( que( condujo( a( la( optimización( de( la( misma.( Un( ensayo( para(
modificar( el( anillo( de( piridina( condujo( a( una( nueva( reacción( de( dimerización( para(
esta(clase(de(compuestos.(
Palabras' clave:! Acilaminometilpiridinas;! Picolilamidas;! Picobenzida;! N5óxidos;!
QSAR.!
ABSTRACT(
Pharmaceutical"Chemistry"of"Acylaminomethylpyridines"
A(new(family(of(central(nervous(system(depressants(has(been(synthesized,(applying(
the(methodology(now(known(as(the("use(of(fragments".(One(of(the(drugs(produced(
by( this( process( was( assigned( the( name( picobencide( by( WHO.( Being( a( substituted(
benzamide,( analogues( were( prepared( modifying( the( substituents( of( the( aromatic(
ring.( A( QSAR( study( was( carried( out( which( led( to( the( optimization( of( the( series.( A(
test( to( modify( the( pyridine( ring( led( to( a( new( dimerization( reaction( of( this( kind( of(
compounds.(
Keywords:! Acylaminomethylyridines;! Pycolilamines;! Picobenzide;! N5oxides;!
QSAR.!
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