Page 16 - 77_01

LOS
PRODUCTOS
NATURALES
EN
EL
DESCUBRIMIENTO…

3. Williams, O. H., Stone, M. J., Hauck, P. R. & Raham, S. R. (1989) Why are secondary
metabolites (natural products) biosynthesized? J. Nat. Prod. 52: 1189-1208.

4. Kingston, D. G. & Newman, D. J. (2005) Natural products as drug leads: An old process or the
new hope for drug discovery? Idrugs. 8: 990-992.

5. a) Harvey, A. L. (2008) Natural products in drug discovery. Drug Discov. Today 13: 894-901. b)
Ganesan, A. (2008) The impact of natural products upon modern drug discovery. Curr. Opin.
Chem. Biol. 12: 306-317.

6. Newman, D. J. & Cragg, G. M. (2007) Natural products as sources of new drugs over the last 25
years. J. Nat. Prod. 70: 461-477.

7. Kingston, D. G. I. (2009) Tubulin-Interactive Natural Products as Anticancer Agents. J. Nat.
Prod. 72: 507-515.

8. Avendaño, C. & Menéndez, J. C. (2008) Medicinal Chemistry of Anticancer Drugs. Ed. Elsevier
B. V. Cap. 8, pág. 229-249.

9. Bochart, J. K. (1999) Combinatorial biosynthesis: panning for pharmaceutical gold. Modern
Drug Discovery. 2: 22-29.

10. a) Paterson, I. & Anderson, E. A. (2005) The Renaissance of natural Products as Drug
Candidates. Science. 310: 451-453. b) Koehn, F. E. & Carter, G. T. (2005) The evolving role
of natural products in drug discovery. Nat. Rev. Drug Discov. 4: 206-220. c) McChesney, J. D.,
Venkataraman, S. K. & Henri, J. T. (2007) Plant natural products: Back to the future or into
extinction? Phytochem. 68: 2015-2022.

11. Rathore, D., Janil, D., Nagarkattil, R. & Kumar, S. (2006) Heme detoxification and antimalarial
drugs – Known mechanisms and future prospects. Drug Discovery Today: Therapeutic
Strategies. 3: 153-158.

12. Nicolaou, K. C. & Guy, R. K. (1995) The Conquest of Taxol. Angew. Chem. Int. Ed. Engl. 34:
2079-2090.

13. Roberts, R. M. (1989) Serendipity: Accidental Discoveries in Science. Wiley, New York.
14. Avendaño, C. (2005) La innovación farmacéutica. Comentarios sobre tres noticias. Anal. Real

Acad. Nac. Farm. 71: 873-904.
15. Shu, Y.-Z. (1998) Recent Natural Products Based Drug Development: A Pharmaceutical

Industry Perspective. J. Nat. Prod. 61: 1053-1071.
16. Dancík, V., Seiler, K. P., Young, D. W., Schreiber, S. L. & Clemons, P. A. (2010) Distinct

Biological Network Properties between the Targets of Natural Products and Disease Genes. J.
Am. Chem. Soc. 132: 9259-9261.
17. Morton, D., Leach, S., Cordier, Ch., Warriner, S. & Nelson, A. (2008) Synthesis of Natural-
Product-Like Molecules with Over Eighty Distinct Scaffolds. Angew. Chem. Int. Ed. Eng. 48:
104-109.
18. a) Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. (1997) Experimental and
computational approaches to estimate solubility and permeability in drug discovery and
development settings. Adv. Drug Deliv. Rev. 23: 3-25. b) Lipinski, C. A., Lombardo, F.,
Dominy, B. W. & Feeney, P. J. (2001) Experimental and computational approaches to estimate
solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev.
46: 3-26.
19. Buckingham, J. (2001) Dictionary of Natural Products on CD-ROM. Chapman & Hall, London.
20. López, S. N., Ramallo, I. A., González, M., Zacchino, S. A. & Burlan, R. L. (2007) Chemically
engineered extracts as an alternative source of bioactive natural product-like compounds.
PNAS. 104: 441-444.
21. a) Newman, D. J. & Cragg, G. M. (2004) Marine natural products and related compounds in
clinical and advanced preclinical trials. J. Nat. Prod. 67: 1216-1238. b) Martínez, A. (2007)
Marine-derived drugs in neurology. Current Opin. Investig. Drugs. 8: 525-530.
22. Glaser, K. B. & Mayer, A. M. S. (2009) A Renaissance in Marine Pharmacology: From
Preclinical Curiosity to Clinical Reality. Biochem. Pharmacol. 78: 440-448.
23. Skov, M. J., Beck, J. C., de Kater, A. W. & Shopp, G. M. (2007) Nonclinical safety of
ziconotide: an intrathecal analgesic of a new pharmaceutical class. Int. J. Toxicol. 26: 411-421.
24. Cuevas, C., Pérez, M., Martín, M. J., Chicharro, J. L., Fernández-Rivas, C., Flores, M.,
Francesch, A., Gallego, P., Zarzuelo, M., Calle, F. de la, García, J., Polanco, C., Rodríguez, I.
& Manzanares, I. (2000) Synthesis of ecteinascidin ET-743 and phtalascidin Pt-650 from
cyanosafracin B. Org. Lett. 2: 2545-2548.
25. De la Calle, F. (2007) Fármacos de Origen Marino. Treballs de la SCB. 58: 141-155.
26. Nagle, D. G., Zhou, Y., Mora, F., Mohammed, K. A. & Kim, Y. (2004) Mechanism targeted
discovery of antitumor marine natural products. Curr. Med. Chem. 11: 1725-1756.

25