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ANTONIO FERRER MONTIEL AN. R. ACAD. NAC. FARM.

Palabras clave: Epidermis; Sistema inmune; Nociceptor; Sensi-
bilización; Canales TRP.

ABSTRACT

Neurogenic inflammation: mechanisms and dermocosmeceutic
opportunities

Cutaneous neurogenic inflammation is emerging as the cause
of diverse skin conditions, as well as dermatological diseases. The
intimate interplay between the dermal immune system and the
peripheral nervous system is central for the biology and physiology
of the skin. A dysfunction in this interaction gives rise to an
inflammatory state that is strengthened by the complementarity
of both cellular systems. Cumulative evidence is signalling to TRPV1
as a key player in the onset and maintenance of neurogenic
inflammation. This thermoreceptor is activated by physical and
chemical stimuli, and its ion channel activity is notably enhanced by
pro-inflammatory mediators such as neurotrophins, interleukin,
kinins and ATP. An increment of TRPV1 activity results in an
augment of neuronal excitability which, in turn, induces the release
of substance P (SP) and a-calcitonin gen-related peptide (a-CGRP)
that paracrinally act and stimulate peripheral immune cells
provoking the release of additional pro-algesic agents. Therefore,
TRPV1 receptor is being considered as a dermatological and
cosmeceutical target and compounds that reduce its activity will be
useful dermocosmetics for the treatment of several cutaneous
conditions.

Key Words: Epidermis; Immune system; Nociceptor; Sensitiza-
tion; TRP channels.

INTRODUCCIÓN

Un concepto emergente en la biología de la piel es el control
neuronal de la fisiología cutánea (1). La piel no es simplemente una
capa dérmica de células cubierta por una envoltura epidérmica de
queratinocitos senescentes. Hay evidencia que indica que el sistema

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