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P. MADRIGAL Y COLS. AN. R. ACAD. NAC. FARM.

have been seen in liver, kidney and lung, where there is more
concentration of free cefotaxime in rats without vanadium than
in rats with it. In spleen and heart, those differences were less
significant, although they are very appreciable. In blood,
concentrations of free cefotaxime were greater in rats without
vanadium, but the differences between concentrations are not as
appreciable as in the others samples that have been analysed. So, the
presence of vanadium is an influential factor in the concentration of
free cefotaxime.

This observation has been supported with the help of a statistical
analysis, here the means of concentrations of free cefotaxime, in
blood, liver, spleen, lung, heart and kidney of rats without vanadium
and of the rats with it, at 30, 60, 90, 120, 150, 180 and 210 min.
after administration of this cephalosporin, have been compared.
This comparison has been done by means of a T distribution with
p < 0.05 (Table III).

TABLE III. Differences more significant in concentrations of free cefotaxime
between rats with vanadium and without it

Samples Time (Min) P Value of T

60 0.04 2.40

90 0.02 2.68

BLOOD 180 6.84.10–4 5.35

60 7.78.10–3 3.52

90 0.04 2.44

LIVER 180 5.46.10–6 10.6

210 2.48.10–9 28.5

30 1.37.10–5 9.37

SPLEEN 210 1.37.10–5 6.03

60 0.01 3.24

90 5.27.10–5 7.79

KIDNEY 150 6.11.10–4 5.44

180 1.22.10–5 9.52

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