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VOL. 72 (4), 599-609, 2006 VANADIUM IN VIVO INTERACTION WITH CEFATOXINE
TABLE III. Differences more significant in concentrations of free cefotaxime
between rats with vanadium and without it (cont.)
Samples Time (Min) P Value of T
210 5.89.10–5 7.76
30 4.03.10–6 11.04
60 8.23.10–8 18.28
90 1.10–5 9.77
LUNG 120 1.44.10–4 6.75
180 4.29.10–7 14.79
210 7.28.10–4 5.29
30 0.01 3.01
HEART 180 7.09.10–3 3.58
210 1.16.10–6 12.9
Therefore, in all those times is dismissed the nule hypothesis
and the averages differences of cefotaxime concentrations were
statistically significant. As deduced from these differences between
the free cefotaxime concentration in rats with and without vanadium
did not happen randomly, so those differences in the concentration
could be due to the formation of antibiotic/metal complex, remaining
a lesser concentration of free cefotaxime.
Distribution of cefotaxime
Tables I and II show the greatest concentration of cefotaxime in
blood. In the assayed organs the concentration of this cephalosporin
is decreasing in the sense: kidney > liver > lung > spleen > heart.
Therefore cefotaxime is mainly stored in kidney. This fact is same in
the 2 groups of rats A and B, and because of this, the metal is not
an influential factor in the distribution of cefotaxime.
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