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VOL. 72 (4), 599-609, 2006 VANADIUM IN VIVO INTERACTION WITH CEFATOXINE

concentration in rats without vanadium is lesser in accordance with
the time that has elapsed since the administration of the antibiotic.
In the Table II, the same case is observed in rats with vanadium, the
greatest cefotaxime concentration is at 30 min. after the administra-
tion of this cephalosporin, and this concentration decreases since
the moment of the administration.

TABLE II. Average concentrations (mg/mL) of free cefotaxime in rats with
vanadium

Time (Min)

Samples 30 60 90 120 150 180 210

BLOOD 0.51 0.25 0.18 0.13 0.12 0.02 0.01

LIVER 4.36.10–5 1.72.10–5 1.41.10–5 1.38.10–5 1.30.10–5 0.32.10–5 0.15.10–5

SPLEEN 1.46.10–5 1.39.10–5 1.38.10–5 0.66.10–5 0.38.10–5 0.37.10–5 0.21.10–5

KIDNEY 20.6.10–5 12.8.10–5 7.58.10–5 5.42.10–5 2.49.10–5 2.38.10–5 1.36.10–5

LUNG 3.86.10–5 2.59.10–5 1.69.10–5 1.59.10–5 1.31.10–5 0.45.10–5 0.23.10–5

HEART 1.88.10–5 1.68.10–5 1.12.10–5 1.11.10–5 1.04.10–5 0.66.10–5 0.29.10–5

Concentrations of cefotaxime, in rats with vanadium and without
it, appeared to decline in a biphasic manner. This decrease in the
cefotaxime concentration happened in the same way that in adults
with a normal renal function (9, 10).

In Table I and II, in all samples of the 2 groups of rats, it could
be noticed two phases in the decrease of cefotaxime concentration.
An initial phase averages 30-90 min. where the concentration
decreased slower.

Cefotaxime concentration does not only change with time, but
also changes in accordance with the intoxication with vanadium.

In rats without vanadium the free cefotaxime concentration
is greater than the concentration in rats with the metal. This fact
happened in blood as well as in the other organs analysed in almost
all times what have been described. The differences more significant

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