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An. R. Acad. Nac. Farm., 2006, 72: 599-609
Artículo original
Vanadium in vivo interaction with cefatoxime
Recibido el 2 de octubre de 2006
MADRIGAL, P. +, DOADRIO, A. L. * +, GONZÁLEZ, P, ++ and
CASAS, J. +++
+ Department of Inorganic Chemistry and Bioinorganic.
School of Pharmacy. University Complutense. Madrid (Spain).
++ Experimental Investigation Unit. Teaching Hospital San Carlos.
Madrid (Spain).
+++ Department of Toxicology and Legal Medicine.
School of Medicine. University Complutense. Madrid (Spain).
ABSTRACT
The presence of V(IV) in penicillin and cephalosporin solutions, has been shown
previously, in vitro, to promote the degradation of the penicillins and cephalosporins
studied to their corresponding penicilloic and cephalosporanic acids. HPLC studies
provided an additional evidence for the reaction mechanism. The mechanisms
of V(IV) catalysis involve a ternary complex. This work was undertaken to study
the consequences of this degradation, in vivo, upper the pharmacokinetic and
pharmacodynamic of Cefotaxime, being these consequences a lower concentracion
of free cefotaxime in blood, liver, spleen, kidney, lung and heart when there was
intoxication with vanadium. The differences more significant between rats with
vanadium and without it were observed in liver, lung and kidney.
Key words: Cefotaxime.—Vanadium.—HPLC.—Pharmacokinetic.—
Pharmacodynamic.
* Author to whom correspondence should be adressed: Departamento de Química
Inorgánica y Bioinorgánica. Facultad de Farmacia. Universidad Complutense. 28040
Madrid (Spain). Email: adoadrio@raf.es
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