Page 43 - 66_01

VOL. 66, (1) 2000 INHIBIDORES FOSFODIESTERASA Y ASMA

(14) BURNS F, RODGER W, PYNE N.J. The catalytic subunit of protein
kinase A triggers activation of the type 5 cyclic GMP-specific
phosphodiesterase from guinea-pig lung. Biochem J, (1992); 283: 487-
491.

(15) FRANCIS S.H, CORBIN J.D. Purification of cGMP-binding protein
phosphodiesterase from rat lung. Methods Enzymol, (1988); 159: 722-
729.

(16) McALLISTER-LUCAS L.M, SONNENBURG W.K, KADLECEK A, et
al.. The structure of a bovine lung cGMP-binding, cGMP-specific
phosphodiesterase deduced from a cDNA clone. J. Biol. Chem., (1993);
268: 22863-22873.

(17) LI T S, VOLPP K, APPLEBURY M L. Bovine cone photoreceptor
cGMP phosphodiesterase structure deduced from a cDNA clone. Proc
Natl Acad Sci USA, (1990); 87: 293-297.

(18) COLLINS C, HUTCHINSON G, KOWBEL D, et al.. The human beta-
subunit of rod photoreceptor cGMP phosphodiesterase: complete retinal
cDNA sequence and evidence for espression in brain. Genomics,
(1992); 13: 698-704.

(19) KHRAMTSOV N.V, FESHCHENKO E.A, SUSLOVA V.A, et al.. The
human rod photoreceptor cGMP phosphodiesterase beta-subunit.
Structural studies of its cDNA and gene. FEBS Lett, (1993); 327: 275-
278.

(20) MICHAELI T, BLOOM T.J, MARTINS T, et al.. Isolation and
characterization of a previously undetected human cAMP
phosphodiesterase by complementation of cAMP phosphodiesterase-
deficient Saccharomices Cerevisiae. J Biol Chem, (1993); 268: 12925-
12932.

(21) BEAVO J.A, REIFSNYDER D.H. Primary sequence of cyclic
nucleotide phosphodiesterase isozymes and the design of selective
inhibitors. TiPS, (1990); 11: 150-155.

(22) NICHOLSON C.D, CHALLISS R.A.J, SHAHID M. Differential
modulation of tissue function and therapeutic potential of selective
inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS,
(1991); 12: 19-27.

(23) MOORE A.R, WILLOUGHBY D.A. The role of cAMP regulation in
controlling inflammation. Clin Exp Immunol., (1995); 101: 387-389.

(24) AL-ESSA L.Y, NIWA M, KOHNO K, et al.. Heterogeneity of
circulating and exudated polymorphonuclear leukocytes in superoxide-
generating response to cyclic AMP and cyclic AMP-elevating agents.
Biochemical Pharmacology, (1995); Vol. 49 (3): 315-322.

21