Page 83 - Demo

ANALESRANFwww.analesranf.com19. Labanieh, L., Majzner, R. G., Mackall, C. L.Programming CAR-T cells to kill cancer.Nature Biomedical Engineering, 2018, 2(6),377-391. https://doi.org/10.1038/s41551-018-0235-9 .20. Zhang, J., Hu, Y., Yang, J., Li, W., Zhang, M.,Wang, Q., Zhang, L., Wei, G., Tian, Y., Zhao,K., Chen, A., Tan, B., Cui, J., Li, D., Li, Y.,Qi, Y., Wang, D., Wu, Y., Li, D., Du, B., %u2026Huang, H. Non-viral, specifically targetedCAR-T cells achieve high safety and efficacyin B-NHL. Nature, 2022, 609(7926), 369%u2013374.https://doi.org/10.1038/s41586-022-05140-y 21. Khan, A., Sarkar, E. CRISPR/CAS9 encouragedCAR-T cell immunotherapy reportingefficient and safe clinical results towardscancer. Cancer treatment and researchcommunications, 2022, 33, 100641.https://doi.org/10.1016/j.ctarc.2022.10064122. Jiang, F., & Doudna, J. A. CRISPR%u2013CAS9structures and mechanisms. Annual Reviewof Biophysics, 2017, 46(1), 505-529.https://doi.org/10.1146/annurev-biophys062215-010822 23. SQUIRE | SQUIRE 2.0 guidelines. (s/f). Squirestatement.org. Recuperado el 9 dediciembre de 2023, de https://www.squirestatement.org/index.cfm?fuseaction=page.viewpage&pageid=47124. Naldini, L., Bl%u00f6mer, U., Gallay, P., Ory, D.,Mulligan, R., Gage, F. H., Verma, I. M., Trono, D. In vivo gene delivery and stabletransduction of nondividing cells by alentiviral vector. Science (New York, N.Y.),1996, 272(5259), 263%u2013267.https://doi.org/10.1126/science.272.5259.263) 25. Perry, C., Rayat, A. C. M. E. Lentiviral VectorBioprocessing. Viruses, 2021, 13(2), 268.https://doi.org/10.3390/v13020268 26. Zincarelli, C., Soltys, S., Rengo, G., Rabinowitz, J. E. Analysis of AAV serotypes1-9 mediated gene expression and tropism inmice after systemic injection. Moleculartherapy : the journal of the American Societyof Gene Therapy, 2008, 16(6), 1073%u20131080.https://doi.org/10.1038/mt.2008.7627. Mingozzi, F., High, K. A. Therapeutic in vivogene transfer for genetic disease using AAV:progress and challenges. Nature reviews.Genetics, 2011, 12(5), 341%u2013355.https://doi.org/10.1038/nrg298811. Cercek, A., Lumish, M., Sinopoli, J., Weiss, J.,Shia, J., Lamendola-Essel, M., El Dika, I. H.,Segal, N., Shcherba, M., Sugarman, R.,Stadler, Z., Yaeger, R., Smith, J. J.,Rousseau, B., Argiles, G., Patel, M., Desai,A., Saltz, L. B., Widmar, M., Iyer, K., %u2026 Diaz,L. A., Jr PD-1 Blockade in Mismatch RepairDeficient, Locally Advanced Rectal Cancer.The New England Journal of Medicine,2022,386(25), 2363%u20132376.https://doi.org/10.1056/NEJMoa2201445 12. Francisco, L. M., Sage, P. T., Sharpe, A. H. ThePD-1 pathway in tolerance andautoimmunity. Immunological Reviews, 2010,236, 219%u2013242. https://doi.org/10.1111/j.1600-065X.2010.00923.x 13. Office of the Commissioner. FDA approves CART cell therapy to treat adults with certaintypes of large B-cell lymphoma. U.S. Foodand Drug Administration. 2017. Obtenido el1 de septiembre de 2023.https://www.fda.gov/news-events/pressannouncements/fda-approves-car-t-cell-therapy-treat-adults-certain-types-large-b-celllymphoma. 14. FDA approves second CAR-T-Cell therapy.National Cancer Institute, 2017, 25 octubre.Obtenido el 1 de septiembre de 2023.https://www.cancer.gov/newsevents/cancer-currents-blog/2017/yescartafda-lymphoma 15. Hacein-Bey-Abina S, von Kalle C, Schmidt M, etal. A serious adverse event after successfulgene therapy for X-linked severe combinedimmunodeficiency. N Engl J Med.2003;348(3):255-256.16. Mohanty, R., Chowdhury, C. R., Arega, S., Sen,P., Ganguly, P., Ganguly, N. CAR-T celltherapy: A new era for cancer treatment(Review). Oncology Reports. 2019.https://doi.org/10.3892/or.2019.7335 17. Qin, X., Wu, F., Chen, C., Li, Q. Recentadvances in CAR-T cells therapy forcolorectal cancer. Frontiers in Immunology,2022, 13.https://doi.org/10.3389/fimmu.2022.90413718. Zhao, L., Cao, Y. Engineered T cell therapyfor cancer in the clinic. Frontiers inImmunology, 2019, 10.https://doi.org/10.3389/fimmu.2019.02250Modulaci%u00f3n del sistema inmune para combatir elc%u00e1ncer mediante CRISPR-Cas9, dependiente oindependiente de la tecnolog%u00eda CAR-TSamuel Torrej%u00f3n y Caroline Weinstein81 An. R. Acad. Farm.Vol. 91. n%u00ba 1 (2025) %u00b7 pp. 67-82