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Y%u2026 %u00bfpor qu%u00e9 lo de %u201cmagia%u201d? Estamos en unarealidad en que la farmacolog%u00eda esextraordinariamente novedosa, y pareciera quenos movemos en el mundo de la magia y lasorpresa. Porque, los fines terap%u00e9uticos que sepersiguen en el momento presente, eran haced%u00e9cadas inimaginables, y menos a trav%u00e9s de last%u00e9cnicas, formas farmac%u00e9uticas y procedimientosactuales que son una combinaci%u00f3n de la actividadmultidisciplinar de muchos especialistas (1). Eneste camino que va desde las f%u00f3rmulasmagistrales, de pr%u00e1ctica muchas veces emp%u00edrica,hasta las nuevas terapias avanzadas, han nacido%u00e1reas que son la combinaci%u00f3n de distintos saberescomo as%u00ed es la Farmacobiotecnolog%u00eda oBiotecnolog%u00eda Farmac%u00e9utica. Somos capaces decontrolar, en parte, a la Biolog%u00eda en su %u201calma%u201d m%u00e1s%u00edntima que es el genoma y somos capaces de crearmodelos animales con una determinada patolog%u00edapara estudiar nuevos f%u00e1rmacos. %u00a1Si nuestrosantepasados levantaran la cabeza! %u00bfNo pareciera1. INTRODUCCI%u00d3NAntes de nada, se ha de justificar la elecci%u00f3n deltema del discurso [La magia de laFarmacobiotecnolog%u00eda: De las magistrales a losvirus recombinantes en terapia g%u00e9nica]. En lahistoria de las sociedades, en general, se produceuna evoluci%u00f3n progresiva, que va en paraleloprecisamente a los avances de la ciencia y enconcreto de la Medicina. Quiz%u00e1s nos podamosplantear sin miedo a equ%u00edvoco, que la farmacolog%u00edaha permitido que se viva m%u00e1s y mejor. Pero,adem%u00e1s, nuestras propias vidas, a veces, siguen,como puede ser en este caso, un paralelismo conestos avances.Partiendo de estas premisas, la elecci%u00f3n delargumento de mi discurso se ha potenciado m%u00e1s sicabe, por la circunstancia en mi caso de tener unorigen, un transcurso y unos fines %u00edntimamenterelacionados con los avances en la Biomedicina.Historia, enfermedad y vocaci%u00f3n investigadora,ser%u00edan las palabras clave definitorias.300ANALESRANFwww.analesranf.comThe magic of Pharmacobiotechnology: From magistrals to recombinant viruses in gene therapyAntonio Liras Mart%u00ednAn. R. Acad. Farm.Vol. 90. n%u00ba 2 (2024) %u00b7 pp. 299-311 ABSTRACTIn the history of societies, in general, there is a progressive evolution, which runs parallelto the progress of science and, in particular, of Medicine. Perhaps it is necessary toconsider, without fear of misunderstanding, that Pharmacology has allowed us to livelonger and better. If we look back, especially those of us who have had the good fortuneof having a very old apothecary's shop, where perhaps our great-grandfather was apharmacist, a lifelong pharmacist, in an almost lost village in the former Castilla La Vieja,around the second half of the 19th century, we can better appreciate the progress thathas been made. But, in addition, if the great-grandson in question chose to follow afamily tradition of being an apothecary, things take on a different dimension, especiallywhen his vocation has been of university professor in Pharmacy and of researcher inBiotechnology. Knowing that we are facing an extraordinarily novel pharmacologicalreality, it would seem that we are moving in the world of magic and surprise. Becausethe therapeutic purposes that are being pursued at the present time were unimaginabledecades ago, and even less so with the current techniques, pharmaceutical forms andprocedures that are a combination of the multidisciplinary activity of many specialists.In this evolution that goes from magistral formulas, of empirical utility, to new advancedtherapies, areas have been born that are the combination of different knowledge, suchas Pharmacobiotechnology. We also control, in part, biology in its most intimate %u201csoul%u201d,which is the genome, and we are able to create animal models with a specific pathologyto study new drugs. Pharmacobiotechnology has made it possible to obtain recombinanttherapeutic proteins in the laboratory; recombinant mono- and bispecific antibodies forthe treatment of cancer and other diseases and, through new therapies, gene therapyand cell therapy, it is possible to correct alterations in the genes that give rise to manyhereditary diseases. However, in this new world of modern pharmacology, which will belargely individualized, the bioethics of healing must be kept in mind, lest the new highcost procedures can further increase social inequity.KEYWORDS Advances inBiomedicineHistoryBiotechnologyAdvanced therapiesRare diseases