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                                                                                  Vallet-Regí M, Esbrit P. Local delivery of parathyroid hormone-related
  www.analesranf.com                                                              protein-derived peptides coated onto a hydroxyapatite-based implant
                                                                                  enhances bone regeneration in old and diabetic rats. J Biomed Mater
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     Alvarez-Arroyo MV, et al. Role of parathyroid hormone-related protein
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     Endocrinology 2009;150: 2027–2035.                                           Regí M, Salinas AJ. Osteostatin potentiates the bioactivity of meso-
                                                                                  porous glass scaffolds containing Zn2+ ions in human mesenchymal
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     parathyroid hormonerelated peptide promotes bone formation in           44. Mumcuoglu D, Siverino C, Tabisz B, Kluijtmans B, Nickel J. How to
     diabetic mice with low turnover osteopenia. Br J Pharmacol                   use BMP-2 for clinical applications? A review on pros and cons of
     2011;162: 1424–1438.                                                         existing delivery strategies. J Transl Sci, 2017; 3:1-11.

34. Portal-Núñez S, Ardura JA, Lozano D, Martínez de Toda I, De la           45. Shirley M. Abaloparatide: first global approval. Drugs 2017; 77:
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35. Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, et al.                                                            Si desea citar nuestro artículo:
     Constitutively active PTH/PTHrP receptor specifically expressed in os-             Uso de péptidos derivados de la proteína relacionada con la
     teoblasts enhances bone formation induced by bone marrow ablation.         parathormona para aumentar la formación y la regeneración ósea
     J Cell Physiol 2012; 227:408–415.
                                                                                                                                        Pedro Esbrit Argüelles
36. de Castro LF, Lozano D, Dapía S, Portal-Núñez S, Caeiro JR, Gómez-                                                         An Real Acad Farm [Internet].
     Barrena E, et al. Role of the N- and C-terminal fragments of pa-                                An. Real Acad. Farm.Vol. 87. nº 4 (2021) · pp 433-443
     rathyroid hormone-related protein as putative therapies to improve                         DOI: http://dx.doi.org/10.53519/analesranf.2021.87.04.06
     bone regeneration under high glucocorticoid treatment. Tissue Eng
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39. Trejo CG, Lozano D, Manzano M, Doadrio JC, Salinas AJ, Dapía S, et
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40. Lozano D, Trejo CG, Gómez-Barrena E, Manzano M, Doadrio JC, Sa-
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     2012; 8: 2317-2323.

41. Lozano D, Sánchez-Salcedo S, Portal-Núñez S, Vila M, López-He-
     rradón A, Ardura JA, Mulero F, Gómez-Barrena E, Vallet-Regí M, Es-
     brit P. Parathyroid hormone-related protein (107-111) improves the
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                                                                                    Uso de péptidos derivados de la proteína relacionada con la

                                                                             443parathormona para aumentar la formación y la regeneración ósea
                                                                                                                            Pedro Esbrit Argüelles
                                                                                                An. Real Acad. Farm.Vol. 87. nº 4 (2021) · pp. 433-443
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