Page 85 - 87_04
P. 85
ANALES 42. Ardura JA, Portal-Núñez S, Lozano D, Gutiérrez-Rojas I, Sánchez-
RANF Salcedo S, López-Herradón A, Mulero F, Villanueva-Peñacarrillo ML,
Vallet-Regí M, Esbrit P. Local delivery of parathyroid hormone-related
www.analesranf.com protein-derived peptides coated onto a hydroxyapatite-based implant
enhances bone regeneration in old and diabetic rats. J Biomed Mater
32. Lozano D, de Castro LF, Dapía S, Andrade-Zapata I, Manzarbeitia F, Res A 2016; 104: 2060-2070.
Alvarez-Arroyo MV, et al. Role of parathyroid hormone-related protein
in the decreased osteoblast function in diabetes-related osteopenia. 43. Heras C, Sánchez-Salcedo S, Lozano D, Peña J, Esbrit P, Vallet-
Endocrinology 2009;150: 2027–2035. Regí M, Salinas AJ. Osteostatin potentiates the bioactivity of meso-
porous glass scaffolds containing Zn2+ ions in human mesenchymal
33. Lozano D, Fernández-de-Castro L, Portal-Núñez S, López-Herradón stem cells. Acta Biomater 2019; 89:359-371.
A, Dapía S, Gómez-Barrena E, Esbrit P. The C-terminal fragment of
parathyroid hormonerelated peptide promotes bone formation in 44. Mumcuoglu D, Siverino C, Tabisz B, Kluijtmans B, Nickel J. How to
diabetic mice with low turnover osteopenia. Br J Pharmacol use BMP-2 for clinical applications? A review on pros and cons of
2011;162: 1424–1438. existing delivery strategies. J Transl Sci, 2017; 3:1-11.
34. Portal-Núñez S, Ardura JA, Lozano D, Martínez de Toda I, De la 45. Shirley M. Abaloparatide: first global approval. Drugs 2017; 77:
Fuente M, Herrero-Beaumont G, Largo R, Esbrit P. Parathyroid hor- 1363–1368.
mone-related protein exhibits antioxidant features in osteoblastic
cells through its N-terminal and osteostatin domains Bone Joint Res 46. Vallet-Regí M. Our contributions to applications of mesoporous silica
2018; 7: 58–68. nanoparticles Acta Biomater 2022; 137: 44–52.
35. Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, et al. Si desea citar nuestro artículo:
Constitutively active PTH/PTHrP receptor specifically expressed in os- Uso de péptidos derivados de la proteína relacionada con la
teoblasts enhances bone formation induced by bone marrow ablation. parathormona para aumentar la formación y la regeneración ósea
J Cell Physiol 2012; 227:408–415.
Pedro Esbrit Argüelles
36. de Castro LF, Lozano D, Dapía S, Portal-Núñez S, Caeiro JR, Gómez- An Real Acad Farm [Internet].
Barrena E, et al. Role of the N- and C-terminal fragments of pa- An. Real Acad. Farm.Vol. 87. nº 4 (2021) · pp 433-443
rathyroid hormone-related protein as putative therapies to improve DOI: http://dx.doi.org/10.53519/analesranf.2021.87.04.06
bone regeneration under high glucocorticoid treatment. Tissue Eng
Part A 2010;16: 1157–1168.
37. Salinas AJ, Esbrit P, Vallet-Regí M. A tissue engineering approach
based on the use of bioceramics for bone repair. Biomat Sci 2013;1:
40-51.
38. Lozano D, Manzano M, Doadrio JC, Salinas AJ, Vallet-Regí M, Gómez-
Barrena E, Esbrit P. Osteostatin-loaded bioceramics stimulate oste-
oblastic growth and differentiation. Acta Biomater 2010; 6:
797-803.
39. Trejo CG, Lozano D, Manzano M, Doadrio JC, Salinas AJ, Dapía S, et
al. The osteoinductive properties of mesoporous silicate coated with
osteostatin in a rabbit femur cavity defect model. Biomaterials
2010;31: 8564–8573.
40. Lozano D, Trejo CG, Gómez-Barrena E, Manzano M, Doadrio JC, Sa-
linas AJ, Vallet-Regí M, García-Honduvilla N, Esbrit P, Buján J. Os-
teostatin-loaded onto mesoporous ceramics improves the early phase
of bone regeneration in a rabbit osteopenia model. Acta Biomater
2012; 8: 2317-2323.
41. Lozano D, Sánchez-Salcedo S, Portal-Núñez S, Vila M, López-He-
rradón A, Ardura JA, Mulero F, Gómez-Barrena E, Vallet-Regí M, Es-
brit P. Parathyroid hormone-related protein (107-111) improves the
bone regeneration potential of gelatin–glutaraldehyde biopolymer-
coated hydroxyapatite. Acta Biomater 2014; 10: 3307–3316.
Uso de péptidos derivados de la proteína relacionada con la
443parathormona para aumentar la formación y la regeneración ósea
Pedro Esbrit Argüelles
An. Real Acad. Farm.Vol. 87. nº 4 (2021) · pp. 433-443